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Aliases for MIR503 Gene

Subcategory (RNA class) for MIR503 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR503 Gene

  • MicroRNA 503 2 3 5
  • Hsa-Mir-503 3
  • Mir-503 3
  • MIRN503 3

External Ids for MIR503 Gene

Previous HGNC Symbols for MIR503 Gene

  • MIRN503

Previous GeneCards Identifiers for MIR503 Gene

  • GC0XM133520
  • GC0XM133522
  • GC0XM133680
  • GC0XM134548
  • GC0XM134555
  • GC0XM134561
  • GC0XM134570
  • GC0XM134575
  • GC0XM134580

Summaries for MIR503 Gene

Entrez Gene Summary for MIR503 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR503 Gene

MIR503 (MicroRNA 503) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DNA damage response and Parkinsons Disease Pathway.

Additional gene information for MIR503 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR503 Gene

Genomics for MIR503 Gene

Regulatory Elements for MIR503 Gene

Enhancers for MIR503 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH134675 1.1 Ensembl ENCODE dbSUPER 12.5 -130.3 -130293 1 BCOR MAFF GATA3 JUND JUN ZMYM3 NR3C1 FOS EP300 LINC00629 MIR450A1 MIR542 MIR450B MIR450A2 MIR503HG MIR503 GC0XP134651 GC0XM134761 RNU4-44P
GH0XH134570 0.7 ENCODE 12.9 -25.5 -25466 3 PKNOX1 NR3C1 ZIC2 FOXA1 NFIC JUND PRDM6 GATA3 ZSCAN16 GLIS1 MIR503HG LINC00629 MIR503 MIR450A1 MIR450A2 MIR542 MIR450B ENSG00000235813
GH0XH134751 0.6 ENCODE 13 -206.5 -206536 2 CTCF ZNF654 REST RAD21 GATA3 SCRT2 SMC3 HMBOX1 PRDM10 LINC00629 MIR503 MIR503HG MIR542 MIR450B MIR450A2 MIR450A1 GC0XM134761 RNU4-44P GC0XP134651
GH0XH134678 0.4 ENCODE 12.5 -133.0 -133002 1 SPI1 LINC00629 MIR450A1 MIR542 MIR450B MIR450A2 MIR503HG MIR503 GC0XP134651 GC0XM134761 RNU4-44P
GH0XH134681 0.2 dbSUPER 12.5 -136.0 -136000 1 MIR503 MIR503HG LINC00629 MIR450A1 MIR450A2 MIR450B MIR542 GC0XP134651 GC0XM134761 RNU4-44P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR503 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR503 Gene

Chromosome:
X
Start:
134,546,328 bp from pter
End:
134,546,398 bp from pter
Size:
71 bases
Orientation:
Minus strand

Genomic View for MIR503 Gene

Genes around MIR503 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR503 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR503 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR503 Gene

Proteins for MIR503 Gene

Post-translational modifications for MIR503 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR503 Gene

Domains & Families for MIR503 Gene

Gene Families for MIR503 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR503: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR503 Gene

Function for MIR503 Gene

Gene Ontology (GO) - Molecular Function for MIR503 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21220732
genes like me logo Genes that share ontologies with MIR503: view

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR503
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR503 Gene

Localization for MIR503 Gene

Gene Ontology (GO) - Cellular Components for MIR503 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072563 endothelial microparticle IDA 26268439
genes like me logo Genes that share ontologies with MIR503: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR503 Gene

Pathways & Interactions for MIR503 Gene

genes like me logo Genes that share pathways with MIR503: view

Pathways by source for MIR503 Gene

Interacting Proteins for MIR503 Gene

Gene Ontology (GO) - Biological Process for MIR503 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001937 negative regulation of endothelial cell proliferation IDA 21220732
GO:0010596 negative regulation of endothelial cell migration IDA 21220732
GO:0010812 negative regulation of cell-substrate adhesion IDA 21220732
GO:0035195 gene silencing by miRNA IDA 21220732
GO:0035278 miRNA mediated inhibition of translation IDA 21220732
genes like me logo Genes that share ontologies with MIR503: view

No data available for SIGNOR curated interactions for MIR503 Gene

Drugs & Compounds for MIR503 Gene

No Compound Related Data Available

Transcripts for MIR503 Gene

mRNA/cDNA for MIR503 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR503
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR503 Gene

No ASD Table

Relevant External Links for MIR503 Gene

GeneLoc Exon Structure for
MIR503
ECgene alternative splicing isoforms for
MIR503

Expression for MIR503 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR503 Gene:

MIR503
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR503 Gene

Orthologs for MIR503 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR503 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Mir503 34
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-503 34
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-503 34
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-503 34
  • 53 (a)
OneToOne
Species where no ortholog for MIR503 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR503 Gene

ENSEMBL:
Gene Tree for MIR503 (if available)
TreeFam:
Gene Tree for MIR503 (if available)

Paralogs for MIR503 Gene

No data available for Paralogs for MIR503 Gene

Variants for MIR503 Gene

Sequence variations from dbSNP and Humsavar for MIR503 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000401062 -- 134,548,235(+) AAGTT(-/AA)AGTCA upstream-variant-2KB
rs1000708197 -- 134,546,080(+) GGACT(G/T)AAGAT intron-variant, downstream-variant-500B
rs1003289199 -- 134,547,514(+) CACAG(A/C)AACTT upstream-variant-2KB
rs1005614992 -- 134,547,140(+) AAAAA(C/T)AAAAA upstream-variant-2KB
rs1009051285 -- 134,546,570(+) GGCCT(A/C)GCGGG nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB

Relevant External Links for MIR503 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR503

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR503 Gene

Disorders for MIR503 Gene

Relevant External Links for MIR503

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR503

No disorders were found for MIR503 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR503 Gene

Publications for MIR503 Gene

  1. miR-503 represses CUG-binding protein 1 translation by recruiting CUGBP1 mRNA to processing bodies. (PMID: 22072795) Cui YH … Wang JY (Molecular biology of the cell 2012) 2 3 60
  2. miR-503 inhibits proliferation making human hepatocellular carcinoma cells susceptible to 5‑fluorouracil by targeting EIF4E. (PMID: 27840964) Yang X … Lei X (Oncology reports 2017) 3 60
  3. miR-503 inhibits platelet-derived growth factor-induced human aortic vascular smooth muscle cell proliferation and migration through targeting the insulin receptor. (PMID: 27829550) Bi R … Liu H (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016) 3 60
  4. An integrative transcriptomics approach identifies miR-503 as a candidate master regulator of the estrogen response in MCF-7 breast cancer cells. (PMID: 27539783) Baran-Gale J … Sethupathy P (RNA (New York, N.Y.) 2016) 3 60
  5. miRNA-503 Promotes Tumor Progression and Is Associated with Early Recurrence and Poor Prognosis in Human Colorectal Cancer. (PMID: 26999740) Noguchi T … Kusunoki M (Oncology 2016) 3 60

Products for MIR503 Gene

Sources for MIR503 Gene

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