Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR503 Gene

Subcategory (RNA class) for MIR503 Gene


Quality Score for this RNA gene is


Aliases for MIR503 Gene

  • MicroRNA 503 2 3
  • Hsa-Mir-503 3
  • MIRN503 3

External Ids for MIR503 Gene

Previous HGNC Symbols for MIR503 Gene

  • MIRN503

Previous GeneCards Identifiers for MIR503 Gene

  • GC0XM133520
  • GC0XM133522
  • GC0XM133680

Summaries for MIR503 Gene

Entrez Gene Summary for MIR503 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR503 Gene

MIR503 (MicroRNA 503) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DDR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR503 Gene

Genomics for MIR503 Gene

Genomic Location for MIR503 Gene

134,546,328 bp from pter
134,546,398 bp from pter
71 bases
Minus strand

Genomic View for MIR503 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR503 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR503 Gene

No data available for Regulatory Elements for MIR503 Gene

Proteins for MIR503 Gene

Post-translational modifications for MIR503 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR503 Gene

Domains for MIR503 Gene

Gene Families for MIR503 Gene

  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR503: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR503 Gene

Function for MIR503 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR503 Gene

Localization for MIR503 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR503 Gene

Pathways for MIR503 Gene

SuperPathways for MIR503 Gene

Superpath Contained pathways
1 miRNAs involved in DDR
genes like me logo Genes that share pathways with MIR503: view

Pathways by source for MIR503 Gene

1 BioSystems pathway for MIR503 Gene

Interacting Proteins for MIR503 Gene

Gene Ontology (GO) - Biological Process for MIR503 Gene


Transcripts for MIR503 Gene

mRNA/cDNA for MIR503 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR503 Gene

No ASD Table

Relevant External Links for MIR503 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR503 Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR503 Gene

Orthologs for MIR503 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR503 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-503 36
  • 53 (a)
(Canis familiaris)
Mammalia cfa-mir-503 36
  • 86 (a)
(Mus musculus)
Mammalia Mir503 36
  • 89 (a)
(Pan troglodytes)
Mammalia ptr-mir-503 36
  • 86 (a)
Species with no ortholog for MIR503:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR503 Gene

Gene Tree for MIR503 (if available)
Gene Tree for MIR503 (if available)

Paralogs for MIR503 Gene

No data available for Paralogs for MIR503 Gene

Variants for MIR503 Gene

Relevant External Links for MIR503 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for MIR503 Gene

Disorders for MIR503 Gene

No disorders were found for MIR503 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR503 Gene

Publications for MIR503 Gene

  1. miR-503 represses CUG-binding protein 1 translation by recruiting CUGBP1 mRNA to processing bodies. (PMID: 22072795) Cui Y.H. … Wang J.Y. (Mol. Biol. Cell 2012) 2 3
  2. Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs. (PMID: 22282338) Voellenkle C. … Martelli F. (RNA 2012) 3
  3. Investigation of the interaction between the MIR-503 and CD40 genes in irradiated U937 cells. (PMID: 22429276) Cheng G. … Jin S. (Radiat Oncol 2012) 3
  4. hsa-miR-503 is downregulated in I^ thalassemia major. (PMID: 22890417) Roy P. … Das M. (Acta Haematol. 2012) 3
  5. An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension. (PMID: 23263626) Kim J. … Chun H.J. (Nat. Med. 2013) 3

Products for MIR503 Gene

Sources for MIR503 Gene

Back to Top