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Aliases for MIR503 Gene

Subcategory (RNA class) for MIR503 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR503 Gene

  • MicroRNA 503 2 3 5
  • Hsa-Mir-503 3
  • Mir-503 3
  • MIRN503 3

External Ids for MIR503 Gene

Previous HGNC Symbols for MIR503 Gene

  • MIRN503

Previous GeneCards Identifiers for MIR503 Gene

  • GC0XM133520
  • GC0XM133522
  • GC0XM133680
  • GC0XM134548
  • GC0XM134555
  • GC0XM134561
  • GC0XM134570

Summaries for MIR503 Gene

Entrez Gene Summary for MIR503 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR503 Gene

MIR503 (MicroRNA 503) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway and miRNAs involved in DDR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR503 Gene

Genomics for MIR503 Gene

Regulatory Elements for MIR503 Gene

Enhancers for MIR503 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF134751 1.1 Ensembl ENCODE 13 -206.5 -206536 2.5 CTCF ZNF654 REST RAD21 GATA3 SCRT2 SMC3 HMBOX1 PRDM10 NFE2 LINC00629 MIR424 MIR503 MIR503HG MIR450A1 MIR450A2 MIR450B MIR542 GC0XM134761 RNU4-44P
GH0XF134570 1 Ensembl ENCODE 12.9 -25.5 -25466 3.5 PKNOX1 ZNF146 ZIC2 GATA3 ZNF600 TCF7L2 ZNF263 CHD1 NR3C1 ATF2 MIR503HG LINC00629 MIR424 MIR503 MIR450A1 MIR450A2 MIR450B MIR542 ENSG00000235813
GH0XF134675 0.9 Ensembl ENCODE 12.5 -130.3 -130293 1.9 BCOR ZNF263 ZNF837 JUN ZMYM3 SIN3A NR3C1 EP300 ZKSCAN1 GATA3 LINC00629 MIR424 MIR503HG MIR450A1 MIR450A2 MIR450B MIR542 MIR503 GC0XP134651 GC0XM134761
GH0XF134678 0.2 ENCODE 12.5 -133.0 -133002 1.3 SREBF1 GLIS1 SPI1 LINC00629 MIR450A1 MIR450A2 MIR450B MIR542 MIR424 MIR503 MIR503HG GC0XP134651 GC0XM134761
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR503 on UCSC Golden Path with GeneCards custom track

Promoters for MIR503 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001919011 1498 1001 CBX2 WT1

Genomic Location for MIR503 Gene

Chromosome:
X
Start:
134,546,328 bp from pter
End:
134,546,398 bp from pter
Size:
71 bases
Orientation:
Minus strand

Genomic View for MIR503 Gene

Genes around MIR503 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR503 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR503 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR503 Gene

Proteins for MIR503 Gene

Post-translational modifications for MIR503 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR503 Gene

Domains & Families for MIR503 Gene

Gene Families for MIR503 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR503: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR503 Gene

Function for MIR503 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR503 Gene

Localization for MIR503 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR503 Gene

Pathways & Interactions for MIR503 Gene

genes like me logo Genes that share pathways with MIR503: view

Pathways by source for MIR503 Gene

2 BioSystems pathways for MIR503 Gene

Interacting Proteins for MIR503 Gene

Gene Ontology (GO) - Biological Process for MIR503 Gene

None

No data available for SIGNOR curated interactions for MIR503 Gene

Transcripts for MIR503 Gene

mRNA/cDNA for MIR503 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR503 Gene

No ASD Table

Relevant External Links for MIR503 Gene

GeneLoc Exon Structure for
MIR503
ECgene alternative splicing isoforms for
MIR503

Expression for MIR503 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR503 Gene:

MIR503
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR503 Gene

Orthologs for MIR503 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR503 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Mir503 35
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-503 35
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-503 35
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-503 35
  • 53 (a)
OneToOne
Species where no ortholog for MIR503 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR503 Gene

ENSEMBL:
Gene Tree for MIR503 (if available)
TreeFam:
Gene Tree for MIR503 (if available)

Paralogs for MIR503 Gene

No data available for Paralogs for MIR503 Gene

Variants for MIR503 Gene

Sequence variations from dbSNP and Humsavar for MIR503 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs11096400 -- 134,545,882(+) GGGAA(A/G)GGAGG intron-variant, downstream-variant-500B
rs111362913 -- 134,547,015(+) GAAGG(C/T)AGACG upstream-variant-2KB
rs138505247 -- 134,548,369(+) TTCAC(C/T)CTAAC upstream-variant-2KB
rs140843777 -- 134,547,412(+) AACTT(A/G)TTTAT upstream-variant-2KB
rs142473917 -- 134,547,050(+) GACAT(C/G)TGGAT upstream-variant-2KB

Relevant External Links for MIR503 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR503

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR503 Gene

Disorders for MIR503 Gene

Relevant External Links for MIR503

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR503

No disorders were found for MIR503 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR503 Gene

Publications for MIR503 Gene

  1. miR-503 represses CUG-binding protein 1 translation by recruiting CUGBP1 mRNA to processing bodies. (PMID: 22072795) Cui Y.H. … Wang J.Y. (Mol. Biol. Cell 2012) 2 3 64
  2. miRNA-503 Promotes Tumor Progression and Is Associated with Early Recurrence and Poor Prognosis in Human Colorectal Cancer. (PMID: 26999740) Noguchi T. … Kusunoki M. (Oncology 2016) 3 64
  3. miR-503 represses human cell proliferation and directly targets the oncogene DDHD2 by non-canonical target pairing. (PMID: 25653011) Polioudakis D. … Iyer V.R. (BMC Genomics 2015) 3 64
  4. MiR-503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression. (PMID: 26047605) Long J. … Liu D. (Tumour Biol. 2015) 3 64
  5. Down-regulation of miR-503 expression predicate advanced mythological features and poor prognosis in patients with NSCLC. (PMID: 26191272) Liu L. … Zhong Z. (Int J Clin Exp Pathol 2015) 3 64

Products for MIR503 Gene

Sources for MIR503 Gene

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