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Aliases for MIR5010 Gene

Subcategory (RNA class) for MIR5010 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR5010 Gene

  • MicroRNA 5010 2 3
  • ATP6V0A1 4 5
  • Clathrin-Coated Vesicle/Synaptic Vesicle Proton Pump 116 KDa Subunit 4
  • Vacuolar Proton Translocating ATPase 116 KDa Subunit A Isoform 1 4
  • Vacuolar Adenosine Triphosphatase Subunit Ac116 4
  • ATPase H+ Transporting V0 Subunit A1 5
  • Vacuolar Proton Pump Subunit 1 4
  • V-ATPase 116 KDa Isoform A1 4
  • Hsa-Mir-5010 3
  • Mir-5010 3
  • ATP6N1A 4
  • ATP6N1 4
  • VPP1 4

External Ids for MIR5010 Gene

Previous GeneCards Identifiers for MIR5010 Gene

  • GC17U901670
  • GC17P040671
  • GC17P042514

Summaries for MIR5010 Gene

Entrez Gene Summary for MIR5010 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5010 Gene

MIR5010 (MicroRNA 5010) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Ion channel transport and Immune System. An important paralog of this gene is ATP6V0A4.

UniProtKB/Swiss-Prot for MIR5010 Gene

  • Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5010 Gene

Genomics for MIR5010 Gene

Regulatory Elements for MIR5010 Gene

Enhancers for MIR5010 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F042308 1.8 FANTOM5 Ensembl ENCODE 16.8 -142.8 -142788 15.9 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 TBX21 MEF2D SSRP1 ENSG00000267758 STAT5A MIR5010 HMGN1P29 STAT5B ATP6V0A1 PTRF DHX58 ENSG00000236194 RNU7-97P
GH17F042515 1.7 FANTOM5 Ensembl ENCODE 12.1 +63.0 63049 12.2 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000267340 MLX TUBG2 ENSG00000267002 PTRF NAGLU RAB5C KAT2A MIR5010 ATP6V0A1
GH17F042245 1.8 FANTOM5 Ensembl ENCODE 9.7 -207.8 -207831 11.6 HDGF PKNOX1 SIN3A ARID4B ZNF2 YY1 SLC30A9 FOS SP3 SP5 STAT5B HCRT KCNH4 ATP6V0A1 MIR5010 CNP STAT5A STAT3 MLX EZH1
GH17F042419 1.5 FANTOM5 ENCODE 11.4 -36.9 -36901 5.2 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF416 ENSG00000267002 LINC00910 ENSG00000267340 KAT2A HMGN1P29 TUBG2 NAGLU MIR5010 ATP6V0A1 DHX58
GH17F042328 1.1 Ensembl ENCODE 15.5 -129.6 -129588 2.4 SIN3A THRB RARA ZNF335 ZNF366 KLF7 ETV6 SMARCA5 SP5 ZBTB2 MIR5010 PTRF STAT5B RNU7-97P ATP6V0A1 ZNF385C STAT3 LOC105371781 GC17M042314 GC17M042386
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR5010 on UCSC Golden Path with GeneCards custom track

Promoters for MIR5010 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001346587 656 2201 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SP3 SP5 NFYC

Genomic Location for MIR5010 Gene

Chromosome:
17
Start:
42,458,844 bp from pter
End:
42,522,611 bp from pter
Size:
63,768 bases
Orientation:
Plus strand

Genomic View for MIR5010 Gene

Genes around MIR5010 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5010 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5010 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5010 Gene

Proteins for MIR5010 Gene

  • Protein details for MIR5010 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93050-VPP1_HUMAN
    Recommended name:
    V-type proton ATPase 116 kDa subunit a isoform 1
    Protein Accession:
    Q93050
    Secondary Accessions:
    • B7Z3B7
    • Q8N5G7
    • Q9NSX0

    Protein attributes for MIR5010 Gene

    Size:
    837 amino acids
    Molecular mass:
    96413 Da
    Quaternary structure:
    • The V-ATPase is a heteromultimeric enzyme composed of at least thirteen different subunits. It has a membrane peripheral V1 sector for ATP hydrolysis and an integral V0 for proton translocation. The V1 sector comprises subunits A-H, whereas V0 includes subunits a, d, c, c, and c.
    • The V-ATPase is a heteromultimeric enzyme composed of at least thirteen different subunits. It has a membrane peripheral V1 sector for ATP hydrolysis and an integral V0 for proton translocation. The V1 sector comprises subunits A-H, whereas V0 includes subunits a, d, c, c, and c.

    Alternative splice isoforms for MIR5010 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR5010 Gene

Post-translational modifications for MIR5010 Gene

  • Ubiquitination at Lys 369 and Lys 666
  • Glycosylation at Asn 488
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MIR5010 Gene

Domains & Families for MIR5010 Gene

Protein Domains for MIR5010 Gene

Graphical View of Domain Structure for InterPro Entry

Q93050

UniProtKB/Swiss-Prot:

VPP1_HUMAN :
  • Belongs to the V-ATPase 116 kDa subunit family.
Family:
  • Belongs to the V-ATPase 116 kDa subunit family.
genes like me logo Genes that share domains with MIR5010: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MIR5010 Gene

Function for MIR5010 Gene

Molecular function for MIR5010 Gene

UniProtKB/Swiss-Prot Function:
Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity).

Gene Ontology (GO) - Molecular Function for MIR5010 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
GO:0015078 hydrogen ion transmembrane transporter activity IEA --
GO:0046961 proton-transporting ATPase activity, rotational mechanism IBA --
GO:0051117 ATPase binding IPI --
genes like me logo Genes that share ontologies with MIR5010: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5010 Gene

Localization for MIR5010 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR5010 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Melanosome. Note=Coated vesicle. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Gene Ontology (GO) - Cellular Components for MIR5010 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell TAS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with MIR5010: view

No data available for Subcellular locations from COMPARTMENTS for MIR5010 Gene

Pathways & Interactions for MIR5010 Gene

genes like me logo Genes that share pathways with MIR5010: view

Pathways by source for MIR5010 Gene

Gene Ontology (GO) - Biological Process for MIR5010 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0007035 vacuolar acidification TAS --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0015986 ATP synthesis coupled proton transport IBA --
genes like me logo Genes that share ontologies with MIR5010: view

No data available for SIGNOR curated interactions for MIR5010 Gene

Transcripts for MIR5010 Gene

mRNA/cDNA for MIR5010 Gene

(26) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5010 Gene

No ASD Table

Relevant External Links for MIR5010 Gene

GeneLoc Exon Structure for
MIR5010
ECgene alternative splicing isoforms for
MIR5010

Expression for MIR5010 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR5010 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR5010 Gene:

MIR5010
genes like me logo Genes that share expression patterns with MIR5010: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR5010 Gene

Orthologs for MIR5010 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR5010 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP6V0A1 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP6V0A1 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP6V0A1 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp6v0a1 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP6V0A1 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP6V0A1 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP6V0A1 35
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP6V0A1 35
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii atp6v0a1b 35
  • 84 (a)
OneToMany
atp6v0a1a 35
  • 82 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Vha100-1 35
  • 61 (a)
ManyToMany
Vha100-2 35
  • 53 (a)
ManyToMany
Vha100-5 35
  • 51 (a)
ManyToMany
Vha100-4 35
  • 48 (a)
ManyToMany
Vha100-3 35
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea unc-32 35
  • 56 (a)
ManyToMany
vha-6 35
  • 46 (a)
ManyToMany
vha-5 35
  • 45 (a)
ManyToMany
vha-7 35
  • 30 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPH1 35 37
  • 40 (a)
ManyToMany
STV1 35
  • 36 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8313 35
  • 62 (a)
ManyToMany
CSA.9891 35
  • 56 (a)
ManyToMany
Species where no ortholog for MIR5010 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR5010 Gene

ENSEMBL:
Gene Tree for MIR5010 (if available)
TreeFam:
Gene Tree for MIR5010 (if available)

Paralogs for MIR5010 Gene

Paralogs for MIR5010 Gene

genes like me logo Genes that share paralogs with MIR5010: view

Variants for MIR5010 Gene

Sequence variations from dbSNP and Humsavar for MIR5010 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111276791 -- 42,513,837(+) ATCTT(A/C)TCTCT intron-variant, upstream-variant-2KB
rs112486216 -- 42,513,139(+) AAAAC(G/T)AAAAC intron-variant, upstream-variant-2KB
rs113328821 -- 42,512,275(+) CGAGG(C/T)TTCTC intron-variant, upstream-variant-2KB
rs115331328 -- 42,514,349(+) CTTGG(C/T)GGGAG intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense
rs138018879 -- 42,513,869(+) GACTT(C/T)GGGGA nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MIR5010 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv1064012 CNV gain 25217958
esv33998 OTHER inversion 15654335

Relevant External Links for MIR5010 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5010

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR5010 Gene

Disorders for MIR5010 Gene

Relevant External Links for MIR5010

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR5010

No disorders were found for MIR5010 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5010 Gene

Publications for MIR5010 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. Enhancing miRNA annotation confidence in miRBase by continuous cross dataset analysis. (PMID: 21558790) Hansen T.B. … Bramsen J.B. (RNA Biol 2011) 3 64
  5. Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome. (PMID: 21807764) Joyce C.E. … Bowcock A.M. (Hum. Mol. Genet. 2011) 3 64

Products for MIR5010 Gene

Sources for MIR5010 Gene

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