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Aliases for MIR501 Gene

Subcategory (RNA class) for MIR501 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR501 Gene

  • MicroRNA 501 2 3 5
  • Hsa-Mir-501 3
  • Mir-501 3
  • MIRN501 3

External Ids for MIR501 Gene

ORGUL Members for MIR501 Gene

Previous HGNC Symbols for MIR501 Gene

  • MIRN501

Previous GeneCards Identifiers for MIR501 Gene

  • GC0XP049667
  • GC0XP049776
  • GC0XP049781
  • GC0XP049783
  • GC0XP049786
  • GC0XP049789
  • GC0XP049792
  • GC0XP049796
  • GC0XP049806
  • GC0XP049836
  • GC0XP050010
  • GC0XP050015
  • GC0XP050018
  • GC0XP050021
  • GC0XP050024

Summaries for MIR501 Gene

Entrez Gene Summary for MIR501 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR501 Gene

MIR501 (MicroRNA 501) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR501 Gene

Genomics for MIR501 Gene

Regulatory Elements for MIR501 Gene

Enhancers for MIR501 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG049976 1.1 Ensembl ENCODE 11.8 -31.4 -31365 3.0 ZFP64 ZNF140 ZNF266 FEZF1 ZNF697 POLR2A ZNF354C PRDM10 ZNF433 TCF7L2 USP27X-AS1 MIR532 MIR188 MIR362 MIR500A MIR500B MIR501 PRAF2 CLCN5 GC0XP049999
GH0XG049957 0.8 Ensembl ENCODE 12.5 -50.0 -50017 3.7 ZNF316 PKNOX1 MAFG NFE2 EMSY SPI1 MIR188 MIR532 MIR362 MIR500A MIR500B MIR501 CLCN5 GC0XM049946 GC0XP049999
GH0XG050034 0.2 ENCODE 13.7 +26.2 26228 2.3 MIR362 MIR500A MIR500B MIR501 MIR188 MIR532 CLCN5 GC0XP050033 PYY3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR501 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR501 Gene

Chromosome:
X
Start:
50,009,722 bp from pter
End:
50,009,805 bp from pter
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR501 Gene

Genes around MIR501 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR501 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR501 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR501 Gene

Proteins for MIR501 Gene

Post-translational modifications for MIR501 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR501 Gene

Domains & Families for MIR501 Gene

Gene Families for MIR501 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR501: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR501 Gene

Function for MIR501 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR501 Gene

Localization for MIR501 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR501 Gene

Pathways & Interactions for MIR501 Gene

SuperPathways for MIR501 Gene

No Data Available

Interacting Proteins for MIR501 Gene

Gene Ontology (GO) - Biological Process for MIR501 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR501 Gene

Drugs & Compounds for MIR501 Gene

No Compound Related Data Available

Transcripts for MIR501 Gene

mRNA/cDNA for MIR501 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR501 Gene

No ASD Table

Relevant External Links for MIR501 Gene

GeneLoc Exon Structure for
MIR501
ECgene alternative splicing isoforms for
MIR501

Expression for MIR501 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR501 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR501 Gene:

MIR501
genes like me logo Genes that share expression patterns with MIR501: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR501 Gene

Orthologs for MIR501 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MIR501 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-501 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir501 35
  • 67 (a)
OneToOne
Species where no ortholog for MIR501 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR501 Gene

ENSEMBL:
Gene Tree for MIR501 (if available)
TreeFam:
Gene Tree for MIR501 (if available)

Paralogs for MIR501 Gene

No data available for Paralogs for MIR501 Gene

Variants for MIR501 Gene

Sequence variations from dbSNP and Humsavar for MIR501 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000551115 -- 50,009,618(+) ATCTG(C/T)CTTAG intron-variant, upstream-variant-2KB
rs1004397043 -- 50,009,098(+) TTTGC(C/T)ATGCG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1008396643 -- 50,007,929(+) CGTAG(A/G)TACCA intron-variant, upstream-variant-2KB
rs1008448846 -- 50,008,466(+) TGAGA(G/T)TGCTG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1009204588 -- 50,010,277(+) GCTCT(A/G)TTGCT intron-variant, downstream-variant-500B, upstream-variant-2KB

Relevant External Links for MIR501 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR501

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR501 Gene

Disorders for MIR501 Gene

Relevant External Links for MIR501

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR501

No disorders were found for MIR501 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR501 Gene

Publications for MIR501 Gene

  1. A Function Variant at miR-501 Alters Susceptibility to Hepatocellular Carcinoma in a Chinese Han Population. (PMID: 27310251) Liu Y. … Tang J. (Cell. Physiol. Biochem. 2016) 3 64
  2. MiR-501-5p regulates CYLD expression and promotes cell proliferation in human hepatocellular carcinoma. (PMID: 25917358) Huang D.H. … Jiang N. (Jpn. J. Clin. Oncol. 2015) 3 64
  3. MicroRNA-501 promotes HBV replication by targeting HBXIP. (PMID: 23266610) Jin J. … Fan D. (Biochem. Biophys. Res. Commun. 2013) 3 64
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64

Products for MIR501 Gene

Sources for MIR501 Gene

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