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Aliases for MIR500B Gene

Subcategory (RNA class) for MIR500B Gene


Quality Score for this RNA gene is


Aliases for MIR500B Gene

  • MicroRNA 500b 2 3 5
  • Hsa-Mir-500b 3
  • Mir-500b 3

External Ids for MIR500B Gene

ORGUL Members for MIR500B Gene

Previous GeneCards Identifiers for MIR500B Gene

  • GC0XU901645
  • GC0XP047245
  • GC0XP049785
  • GC0XP049788
  • GC0XP049791
  • GC0XP049794
  • GC0XP049798
  • GC0XP049812
  • GC0XP049838
  • GC0XP050011
  • GC0XP050016
  • GC0XP050019
  • GC0XP050022

Summaries for MIR500B Gene

Entrez Gene Summary for MIR500B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR500B Gene

MIR500B (MicroRNA 500b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR500B Gene

Genomics for MIR500B Gene

Regulatory Elements for MIR500B Gene

Enhancers for MIR500B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF050034 0.2 ENCODE 13.7 +25.3 25278 2.3 MIR362 MIR500A MIR500B MIR501 MIR188 MIR532 CLCN5 GC0XP050030 PYY3
GH0XF049957 1.3 Ensembl ENCODE 12.5 -51.0 -50967 3.7 ZNF316 PKNOX1 MAFG NFE2 EMSY SPI1 MIR188 MIR532 MIR362 MIR500A MIR500B MIR501 CLCN5 GC0XM049946 GC0XP049999
GH0XF049976 0.5 Ensembl ENCODE 11.8 -32.3 -32315 3.0 ZFP64 ZNF140 ZNF266 FEZF1 ZNF354C POLR2A PRDM10 ZNF433 TCF7L2 ZNF202 ENSG00000270012 USP27X-AS1 MIR532 MIR188 MIR362 MIR500A MIR500B MIR501 PRAF2 CLCN5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR500B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR500B Gene

50,010,672 bp from pter
50,010,750 bp from pter
79 bases
Plus strand

Genomic View for MIR500B Gene

Genes around MIR500B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR500B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR500B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR500B Gene

Proteins for MIR500B Gene

Post-translational modifications for MIR500B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR500B Gene

Domains & Families for MIR500B Gene

Gene Families for MIR500B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR500B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR500B Gene

Function for MIR500B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR500B Gene

Localization for MIR500B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR500B Gene

Pathways & Interactions for MIR500B Gene

SuperPathways for MIR500B Gene

No Data Available

Interacting Proteins for MIR500B Gene

Gene Ontology (GO) - Biological Process for MIR500B Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR500B Gene

Transcripts for MIR500B Gene

mRNA/cDNA for MIR500B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR500B Gene

No ASD Table

Relevant External Links for MIR500B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR500B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR500B Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR500B Gene

Orthologs for MIR500B Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR500B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-500-2 35
  • 100 (a)
(Canis familiaris)
Mammalia -- 35
  • 88 (a)
(Bos Taurus)
Mammalia bta-mir-500 35
  • 86 (a)
Species where no ortholog for MIR500B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR500B Gene

Gene Tree for MIR500B (if available)
Gene Tree for MIR500B (if available)

Paralogs for MIR500B Gene

No data available for Paralogs for MIR500B Gene

Variants for MIR500B Gene

Sequence variations from dbSNP and Humsavar for MIR500B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs112489955 -- 50,009,781(+) CACCC(A/G)GGCAA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs140725573 -- 50,011,091(+) GAGAC(A/G)TGTCC intron-variant, downstream-variant-500B
rs141215482 -- 50,009,612(+) AGAGG(C/T)ATCTG intron-variant, upstream-variant-2KB
rs149202543 -- 50,009,839(+) TATGT(C/T)ACCTC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs149596 -- 50,009,197(+) ATGAA(A/C)TTCAT intron-variant, downstream-variant-500B, upstream-variant-2KB

Relevant External Links for MIR500B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR500B Gene

Disorders for MIR500B Gene

Relevant External Links for MIR500B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR500B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR500B Gene

Publications for MIR500B Gene

  1. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J. … Kaessmann H. (Genome Res. 2013) 3 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff L.A. … Hart R.P. (PLoS ONE 2009) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR500B Gene

Sources for MIR500B Gene

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