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Aliases for MIR500A Gene

Subcategory (RNA class) for MIR500A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR500A Gene

  • MicroRNA 500a 2 3 5
  • MicroRNA 500 2 3
  • Hsa-Mir-500a 3
  • Hsa-Mir-500 3
  • Mir-500a 3
  • MIRN500 3
  • MIR500 3

External Ids for MIR500A Gene

ORGUL Members for MIR500A Gene

Previous HGNC Symbols for MIR500A Gene

  • MIRN500
  • MIR500

Previous GeneCards Identifiers for MIR500A Gene

  • GC0XP049782
  • GC0XP049784
  • GC0XP049787
  • GC0XP049790
  • GC0XP049793
  • GC0XP049797
  • GC0XP049811
  • GC0XP049837

Summaries for MIR500A Gene

Entrez Gene Summary for MIR500A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR500A Gene

MIR500A (MicroRNA 500a) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR500A Gene

Genomics for MIR500A Gene

Regulatory Elements for MIR500A Gene

Enhancers for MIR500A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG049976 1.1 Ensembl ENCODE 11.8 -30.1 -30074 3.0 ZFP64 ZNF140 ZNF266 FEZF1 ZNF697 POLR2A ZNF354C PRDM10 ZNF433 TCF7L2 USP27X-AS1 MIR532 MIR188 MIR500A MIR500B MIR501 MIR362 PRAF2 CLCN5 GC0XP049999
GH0XG049957 0.8 Ensembl ENCODE 12.5 -48.7 -48726 3.7 ZNF316 PKNOX1 MAFG NFE2 EMSY SPI1 MIR532 MIR188 MIR500A MIR362 MIR501 MIR500B CLCN5 GC0XM049946 GC0XP049999
GH0XG050034 0.2 ENCODE 13.7 +27.5 27519 2.3 MIR362 MIR501 MIR500B MIR500A MIR188 MIR532 CLCN5 GC0XP050033 PYY3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR500A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR500A Gene

Chromosome:
X
Start:
50,008,431 bp from pter
End:
50,008,514 bp from pter
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR500A Gene

Genes around MIR500A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR500A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR500A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR500A Gene

Proteins for MIR500A Gene

Post-translational modifications for MIR500A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR500A Gene

Domains & Families for MIR500A Gene

Gene Families for MIR500A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR500A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR500A Gene

Function for MIR500A Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR500A Gene

Localization for MIR500A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR500A Gene

Pathways & Interactions for MIR500A Gene

SuperPathways for MIR500A Gene

No Data Available

Interacting Proteins for MIR500A Gene

Gene Ontology (GO) - Biological Process for MIR500A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR500A Gene

Drugs & Compounds for MIR500A Gene

No Compound Related Data Available

Transcripts for MIR500A Gene

mRNA/cDNA for MIR500A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR500A Gene

No ASD Table

Relevant External Links for MIR500A Gene

GeneLoc Exon Structure for
MIR500A
ECgene alternative splicing isoforms for
MIR500A

Expression for MIR500A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR500A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR500A Gene:

MIR500A
genes like me logo Genes that share expression patterns with MIR500A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR500A Gene

Orthologs for MIR500A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR500A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-500-1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-500 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-502b 35
  • 88 (a)
OneToOne
Species where no ortholog for MIR500A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR500A Gene

ENSEMBL:
Gene Tree for MIR500A (if available)
TreeFam:
Gene Tree for MIR500A (if available)

Paralogs for MIR500A Gene

No data available for Paralogs for MIR500A Gene

Variants for MIR500A Gene

Sequence variations from dbSNP and Humsavar for MIR500A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1006776340 -- 50,006,654(+) TCTCA(A/T)TTGCT intron-variant, upstream-variant-2KB
rs1008396643 -- 50,007,929(+) CGTAG(A/G)TACCA intron-variant, upstream-variant-2KB
rs1008448846 -- 50,008,466(+) TGAGA(G/T)TGCTG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1012297653 -- 50,007,433(+) TCTCT(C/G)TCTCT intron-variant, upstream-variant-2KB
rs1012410619 -- 50,007,206(+) TACTC(A/G)TATAT intron-variant, upstream-variant-2KB

Relevant External Links for MIR500A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR500A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR500A Gene

Disorders for MIR500A Gene

Relevant External Links for MIR500A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR500A

No disorders were found for MIR500A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR500A Gene

Publications for MIR500A Gene

  1. MicroRNA-500 sustains nuclear factor-I_B activation and induces gastric cancer cell proliferation and resistance to apoptosis. (PMID: 25595906) Zhang L. … Zhang D. (Oncotarget 2015) 3 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma. (PMID: 19863192) Yamamoto Y. … Ochiya T. (Biomarkers 2009) 3 64
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR500A Gene

Sources for MIR500A Gene

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