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Aliases for MIR5006 Gene

Subcategory (RNA class) for MIR5006 Gene


Quality Score for this RNA gene is


Aliases for MIR5006 Gene

  • MicroRNA 5006 2 3
  • VWA8 4 5
  • Von Willebrand Factor A Domain Containing 8 5
  • Hsa-Mir-5006 3
  • KIAA0564 4

External Ids for MIR5006 Gene

Previous GeneCards Identifiers for MIR5006 Gene

  • GC13U900900
  • GC13M042145

Summaries for MIR5006 Gene

Entrez Gene Summary for MIR5006 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5006 Gene

MIR5006 (MicroRNA 5006) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5006 Gene

Genomics for MIR5006 Gene

Regulatory Elements for MIR5006 Gene

Enhancers for MIR5006 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F041644 1.6 FANTOM5 Ensembl ENCODE 9.7 +312.4 312446 9.1 PKNOX1 ZFP64 ARID4B FEZF1 YY1 SP5 TSHZ1 REST PPARG ZNF623 RGCC VWA8 NAA16 OR7E155P OR7E37P RNU6-57P ENSG00000231530 DGKH MIR5006 GC13M041633
GH13F041915 1.2 Ensembl ENCODE 11.5 +44.4 44369 3.3 ATF1 TBL1XR1 INSM2 BMI1 FEZF1 ZNF366 CBX5 SCRT2 ETV6 FOS VWA8 MIR5006 KARSP1 RNU6-74P
GH13F041996 1.2 Ensembl ENCODE 11.3 -35.1 -35081 0.4 PKNOX1 ATF1 ARNT ELK1 GATA2 MBD2 MEF2D MAFF SMARCA4 PBX2 MIR5006 VWA8 GC13M041982 GC13P041978
GH13F042046 1 ENCODE 10.3 -87.3 -87298 2.9 SIN3A GLI4 ZNF48 ZNF2 ZNF121 GLIS2 ZNF207 SP3 REST SMARCA4 RNU6-74P MIR5006 VWA8 ENSG00000231530 GC13M042068
GH13F042105 1 Ensembl ENCODE 10.3 -145.0 -144988 1.7 ZNF146 JUN INSM2 KLF17 CTBP1 ZNF366 PRDM10 ZNF600 FOS ZNF639 ENSG00000231530 DGKH RNU6-74P MIR5006 VWA8 GC13M042088 GC13M042182
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR5006 on UCSC Golden Path with GeneCards custom track

Promoters for MIR5006 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001509199 420 2201 PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A GLI4 DMAP1 ZNF48 ZNF2 YY1

Genomic Location for MIR5006 Gene

41,566,837 bp from pter
41,961,120 bp from pter
394,284 bases
Minus strand

Genomic View for MIR5006 Gene

Genes around MIR5006 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5006 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5006 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5006 Gene

Proteins for MIR5006 Gene

  • Protein details for MIR5006 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    von Willebrand factor A domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • O60310
    • Q5JTP6
    • Q5VW08
    • Q7Z6I9
    • Q86YC9
    • Q8N3E4

    Protein attributes for MIR5006 Gene

    1905 amino acids
    Molecular mass:
    214824 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MIR5006 Gene


neXtProt entry for MIR5006 Gene

Post-translational modifications for MIR5006 Gene

  • Glycosylation at Asn 284, Asn 855, Asn 1096, Asn 1142, and Asn 1833
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR5006 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MIR5006 Gene

Domains & Families for MIR5006 Gene

Protein Domains for MIR5006 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 VWFA domain.
  • Contains 1 VWFA domain.
genes like me logo Genes that share domains with MIR5006: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MIR5006 Gene

Function for MIR5006 Gene

Gene Ontology (GO) - Molecular Function for MIR5006 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IEA --
genes like me logo Genes that share ontologies with MIR5006: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5006 Gene

Localization for MIR5006 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR5006 Gene

Gene Ontology (GO) - Cellular Components for MIR5006 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with MIR5006: view

No data available for Subcellular locations from COMPARTMENTS for MIR5006 Gene

Pathways & Interactions for MIR5006 Gene

SuperPathways for MIR5006 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR5006 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR5006 Gene

Transcripts for MIR5006 Gene

mRNA/cDNA for MIR5006 Gene

(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5006 Gene

No ASD Table

Relevant External Links for MIR5006 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR5006 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR5006 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR5006 Gene:

genes like me logo Genes that share expression patterns with MIR5006: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR5006 Gene

Orthologs for MIR5006 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR5006 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VWA8 35
  • 99 (a)
(Canis familiaris)
Mammalia VWA8 35
  • 92 (a)
(Bos Taurus)
Mammalia VWA8 35
  • 88 (a)
(Mus musculus)
Mammalia Vwa8 35
  • 86 (a)
(Monodelphis domestica)
Mammalia VWA8 35
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia VWA8 35
  • 74 (a)
(Gallus gallus)
Aves VWA8 35
  • 78 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 86 (a)
-- 35
  • 76 (a)
(Danio rerio)
Actinopterygii vwa8 35
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta c12.2 35
  • 52 (a)
(Caenorhabditis elegans)
Secernentea F11C1.5 35
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4168 35
  • 54 (a)
Species where no ortholog for MIR5006 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR5006 Gene

Gene Tree for MIR5006 (if available)
Gene Tree for MIR5006 (if available)

Paralogs for MIR5006 Gene Pseudogenes for MIR5006 Gene

genes like me logo Genes that share paralogs with MIR5006: view

No data available for Paralogs for MIR5006 Gene

Variants for MIR5006 Gene

Sequence variations from dbSNP and Humsavar for MIR5006 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs112887589 -- 41,570,136(+) AAAAT(C/G)ATTAG intron-variant, upstream-variant-2KB
rs114798921 -- 41,568,895(+) AACTC(A/G)TTTTT intron-variant, upstream-variant-2KB
rs116509812 -- 41,568,727(+) ACAGG(C/T)CTCTA intron-variant, upstream-variant-2KB
rs117518276 -- 41,568,614(+) TTCTT(C/T)TGGTA intron-variant, upstream-variant-2KB
rs117894021 -- 41,568,799(+) TTTTT(C/G)GTCCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR5006 Gene

Variant ID Type Subtype PubMed ID
dgv1634n100 CNV gain 25217958
nsv455865 CNV gain 19166990
nsv561539 CNV gain 21841781

Relevant External Links for MIR5006 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR5006 Gene

Disorders for MIR5006 Gene

Relevant External Links for MIR5006

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR5006 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5006 Gene

Publications for MIR5006 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  2. Enhancing miRNA annotation confidence in miRBase by continuous cross dataset analysis. (PMID: 21558790) Hansen T.B. … Bramsen J.B. (RNA Biol 2011) 3 64
  3. Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia. (PMID: 21606961) Schotte D. … den Boer M.L. (Leukemia 2011) 3 64
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for MIR5006 Gene

Sources for MIR5006 Gene

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