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Aliases for MIR5004 Gene

Subcategory (RNA class) for MIR5004 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR5004 Gene

  • MicroRNA 5004 2 3 5
  • Hsa-Mir-5004 3
  • Mir-5004 3

External Ids for MIR5004 Gene

Previous GeneCards Identifiers for MIR5004 Gene

  • GC06U902261

Summaries for MIR5004 Gene

Entrez Gene Summary for MIR5004 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5004 Gene

MIR5004 (MicroRNA 5004) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are RET signaling and Cytokine Signaling in Immune system.

Additional gene information for MIR5004 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5004 Gene

Genomics for MIR5004 Gene

GeneHancer (GH) Regulatory Elements for MIR5004 Gene

Promoters and enhancers for MIR5004 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I033423 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -11.3 -11346 6 HDGF PKNOX1 SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A YBX1 DMAP1 DAXX LEMD2 BRD2 WDR46 RXRB VPS52 RGL2 SYNGAP1 KIFC1 RPS10
GH06I033430 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 0.4 -5.9 -5911 4.5 HDGF ATF1 FOXA2 ARID4B SIN3A ZNF48 GLIS2 ELK1 ZNF143 FOS RING1 HCG25 ZBTB9 DAXX PHF1 SYNGAP1 LOC105375022 LEMD2 VPS52 SMIM29
GH06I033421 Enhancer 1.1 Ensembl dbSUPER 0.4 -16.8 -16830 0.6 HDGF PKNOX1 ARNT SIN3A GLI4 TCF12 CBX5 E2F8 NCOA1 REST SYNGAP1 DAXX BRD2 LEMD2 WDR46 RGL2 VPS52 RXRB B3GALT4 ITPR3
GH06I033449 Enhancer 0.3 Ensembl 0.4 +12.1 12070 1.2 POLR2A CUTA ENSG00000274259 ZBTB9 MIR5004 SYNGAP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR5004 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR5004 Gene

Genomic Locations for MIR5004 Gene
chr6:33,438,331-33,438,437
(GRCh38/hg38)
Size:
107 bases
Orientation:
Plus strand
chr6:33,406,108-33,406,214
(GRCh37/hg19)

Genomic View for MIR5004 Gene

Genes around MIR5004 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5004 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5004 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5004 Gene

Proteins for MIR5004 Gene

Post-translational modifications for MIR5004 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5004 Gene

Domains & Families for MIR5004 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR5004 Gene

Function for MIR5004 Gene

Phenotypes From GWAS Catalog for MIR5004 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5004 Gene

Localization for MIR5004 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR5004 Gene

Pathways & Interactions for MIR5004 Gene

SuperPathways for MIR5004 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 HIV Life Cycle
.45
5 Innate Immune System
genes like me logo Genes that share pathways with MIR5004: view

Pathways by source for MIR5004 Gene

Interacting Proteins for MIR5004 Gene

Gene Ontology (GO) - Biological Process for MIR5004 Gene

None

No data available for SIGNOR curated interactions for MIR5004 Gene

Drugs & Compounds for MIR5004 Gene

No Compound Related Data Available

Transcripts for MIR5004 Gene

mRNA/cDNA for MIR5004 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5004 Gene

No ASD Table

Relevant External Links for MIR5004 Gene

GeneLoc Exon Structure for
MIR5004
ECgene alternative splicing isoforms for
MIR5004

Expression for MIR5004 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR5004 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR5004 Gene:

MIR5004
genes like me logo Genes that share expression patterns with MIR5004: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR5004 Gene

Orthologs for MIR5004 Gene

Evolution for MIR5004 Gene

ENSEMBL:
Gene Tree for MIR5004 (if available)
TreeFam:
Gene Tree for MIR5004 (if available)

No data available for Orthologs for MIR5004 Gene

Paralogs for MIR5004 Gene

No data available for Paralogs for MIR5004 Gene

Variants for MIR5004 Gene

Sequence variations from dbSNP and Humsavar for MIR5004 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1060503378 pathogenic, Mental retardation, autosomal dominant 5, not provided 33,438,072(+) AG/ upstream_transcript_variant
rs144778033 likely-benign, Mental retardation, autosomal dominant 5 33,437,971(+) C/T upstream_transcript_variant
rs72887798 benign, Mental retardation, autosomal dominant 5 33,438,523(+) T/C downstream_transcript_variant
rs748333558 uncertain-significance, not provided, Global developmental delay 33,438,190(+) C/T upstream_transcript_variant
rs751331097 benign, Mental retardation, autosomal dominant 5 33,438,255(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR5004 Gene

Variant ID Type Subtype PubMed ID
nsv1019212 CNV gain 25217958
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv602832 CNV loss 21841781
nsv830635 CNV loss 17160897
nsv830637 CNV loss 17160897

Additional Variant Information for MIR5004 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5004

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR5004 Gene

Disorders for MIR5004 Gene

Additional Disease Information for MIR5004

No disorders were found for MIR5004 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5004 Gene

Publications for MIR5004 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  2. Enhancing miRNA annotation confidence in miRBase by continuous cross dataset analysis. (PMID: 21558790) Hansen TB … Bramsen JB (RNA biology 2011) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR5004 Gene

Sources for MIR5004 Gene

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