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Aliases for MIR5004 Gene

Subcategory (RNA class) for MIR5004 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR5004 Gene

  • MicroRNA 5004 2 3 5
  • Hsa-Mir-5004 3
  • Mir-5004 3

External Ids for MIR5004 Gene

Previous GeneCards Identifiers for MIR5004 Gene

  • GC06U902261

Summaries for MIR5004 Gene

Entrez Gene Summary for MIR5004 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5004 Gene

MIR5004 (MicroRNA 5004) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are RET signaling and Signaling by PTK6.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5004 Gene

Genomics for MIR5004 Gene

Regulatory Elements for MIR5004 Gene

Enhancers for MIR5004 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G033423 1.8 FANTOM5 ENCODE dbSUPER 0.4 -12.4 -12367 3.9 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A YBX1 DMAP1 FEZF1 DAXX WDR46 BRD2 VPS52 LEMD2 RXRB ZBTB9 KIFC1 RPL35AP4 SYNGAP1
GH06G033428 1.6 FANTOM5 ENCODE dbSUPER 0.4 -9.2 -9221 1.7 HDGF PKNOX1 ATF1 FOXA2 ZFP64 ARID4B SIN3A YBX1 DMAP1 TCF12 ZBTB9 SMIM29 RPL35AP4 KIFC1 CUTA BAK1 SYNGAP1 MIR5004
GH06G033430 1.5 FANTOM5 ENCODE dbSUPER 0.4 -5.9 -5912 4.5 HDGF ATF1 FOXA2 ARID4B SIN3A ZNF48 GLIS2 ELK1 ZNF143 FOS RING1 HCG25 DAXX ZBTB9 SYNGAP1 LEMD2 VPS52 SMIM29 PHF1 KIFC1
GH06G033421 1.2 Ensembl dbSUPER 0.4 -16.8 -16831 0.6 HDGF PKNOX1 ARNT GLI4 TCF12 CBX5 GATA2 NCOA1 REST ZNF518A DAXX BRD2 ITPR3 LEMD2 RGL2 WDR46 B3GALT4 VPS52 CUTA RXRB
GH06G033449 1.1 Ensembl 0.4 +12.1 12070 1.2 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 CUTA ZBTB9 MIR5004
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR5004 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR5004 Gene

Chromosome:
6
Start:
33,438,331 bp from pter
End:
33,438,437 bp from pter
Size:
107 bases
Orientation:
Plus strand

Genomic View for MIR5004 Gene

Genes around MIR5004 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5004 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5004 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5004 Gene

Proteins for MIR5004 Gene

Post-translational modifications for MIR5004 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5004 Gene

Domains & Families for MIR5004 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR5004 Gene

Function for MIR5004 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5004 Gene

Localization for MIR5004 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR5004 Gene

Pathways & Interactions for MIR5004 Gene

SuperPathways for MIR5004 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 HIV Life Cycle
.45
5 Innate Immune System
genes like me logo Genes that share pathways with MIR5004: view

Pathways by source for MIR5004 Gene

Interacting Proteins for MIR5004 Gene

Gene Ontology (GO) - Biological Process for MIR5004 Gene

None

No data available for SIGNOR curated interactions for MIR5004 Gene

Drugs & Compounds for MIR5004 Gene

No Compound Related Data Available

Transcripts for MIR5004 Gene

mRNA/cDNA for MIR5004 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5004 Gene

No ASD Table

Relevant External Links for MIR5004 Gene

GeneLoc Exon Structure for
MIR5004
ECgene alternative splicing isoforms for
MIR5004

Expression for MIR5004 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR5004 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR5004 Gene:

MIR5004
genes like me logo Genes that share expression patterns with MIR5004: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR5004 Gene

Orthologs for MIR5004 Gene

Evolution for MIR5004 Gene

ENSEMBL:
Gene Tree for MIR5004 (if available)
TreeFam:
Gene Tree for MIR5004 (if available)

No data available for Orthologs for MIR5004 Gene

Paralogs for MIR5004 Gene

No data available for Paralogs for MIR5004 Gene

Variants for MIR5004 Gene

Sequence variations from dbSNP and Humsavar for MIR5004 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1057518183 Pathogenic 33,438,425(+) ACTTC(-/C)TTTCA nc-transcript-variant, reference, frameshift-variant
rs797046028 Pathogenic 33,438,819(+) GCGAG(-/G)TAGAC downstream-variant-500B, reference, frameshift-variant
rs863224930 Pathogenic 33,437,801(+) GCCCC(-/G)CTCTG upstream-variant-2KB, reference, frameshift-variant
rs7759963 Likely benign 33,438,779(+) GGAGA(A/G)TTCAT downstream-variant-500B, reference, synonymous-codon
rs201107225 Uncertain significance 33,438,487(+) TTCCG(C/T)GAGAA downstream-variant-500B, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MIR5004 Gene

Variant ID Type Subtype PubMed ID
nsv1019212 CNV gain 25217958
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv602832 CNV loss 21841781
nsv830635 CNV loss 17160897
nsv830637 CNV loss 17160897

Relevant External Links for MIR5004 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5004

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR5004 Gene

Disorders for MIR5004 Gene

Relevant External Links for MIR5004

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR5004

No disorders were found for MIR5004 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5004 Gene

Publications for MIR5004 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Enhancing miRNA annotation confidence in miRBase by continuous cross dataset analysis. (PMID: 21558790) Hansen T.B. … Bramsen J.B. (RNA Biol 2011) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR5004 Gene

Sources for MIR5004 Gene

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