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Aliases for MIR5001 Gene

Subcategory (RNA class) for MIR5001 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR5001 Gene

  • MicroRNA 5001 2 3
  • TIGD1 4 5
  • Tigger Transposable Element Derived 1 5
  • Hsa-Mir-5001 3
  • Mir-5001 3

External Ids for MIR5001 Gene

Previous GeneCards Identifiers for MIR5001 Gene

  • GC02U902458
  • GC02M233420

Summaries for MIR5001 Gene

Entrez Gene Summary for MIR5001 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5001 Gene

MIR5001 (MicroRNA 5001) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is TIGD2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5001 Gene

Genomics for MIR5001 Gene

Regulatory Elements for MIR5001 Gene

Enhancers for MIR5001 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F232572 0.5 ENCODE 11.5 -23.5 -23496 2.7 SOX13 ELF3 DRAP1 TBP ZNF792 SAP130 ARID4B RARA YY1 GATA3 EIF4E2 TIGD1 MIR5001 ECEL1 GIGYF2 PIR51534
GH02F233266 1 Ensembl ENCODE 11.2 -718.8 -718804 6.1 HDGF SIN3A FEZF1 ZBTB40 ZNF335 SCRT2 FOS CREM ZNF263 CBFB ATG16L1 MIR5001 SAG KCNJ13 GIGYF2 GC02P233277
GH02F232592 1.3 Ensembl ENCODE 10.9 -42.6 -42579 1.8 CTCF RFX1 HLF JUN CEBPB CEBPG RAD21 SREBF1 CEBPA FOS EIF4E2 MIR5001 TIGD1 EFHD1 PIR51534
GH02F232549 0.8 ENCODE 0.8 -0.2 -159 2.5 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 TIGD1 CHRNG PRSS56 MIR5001 PIR51534
GH02F232566 1.4 Ensembl ENCODE 0.3 -17.4 -17425 2.3 ZNF146 JUND JUN FOS TCF7L2 NFE2L2 EIF4E2 LOC105373929 CHRNG CHRND PRSS56 ECEL1 GIGYF2 PIR51534 TIGD1 MIR5001
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR5001 on UCSC Golden Path with GeneCards custom track

Promoters for MIR5001 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000125725 -9 2400 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for MIR5001 Gene

Chromosome:
2
Start:
232,547,968 bp from pter
End:
232,550,592 bp from pter
Size:
2,625 bases
Orientation:
Minus strand

Genomic View for MIR5001 Gene

Genes around MIR5001 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5001 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5001 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5001 Gene

Proteins for MIR5001 Gene

  • Protein details for MIR5001 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MW7-TIGD1_HUMAN
    Recommended name:
    Tigger transposable element-derived protein 1
    Protein Accession:
    Q96MW7
    Secondary Accessions:
    • Q6P4D2
    • Q6PIF9

    Protein attributes for MIR5001 Gene

    Size:
    591 amino acids
    Molecular mass:
    67299 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MIR5001 Gene

Post-translational modifications for MIR5001 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR5001 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MIR5001 Gene

Domains & Families for MIR5001 Gene

Protein Domains for MIR5001 Gene

Graphical View of Domain Structure for InterPro Entry

Q96MW7

UniProtKB/Swiss-Prot:

TIGD1_HUMAN :
  • Contains 1 DDE-1 domain.
  • Belongs to the tigger transposable element derived protein family.
Domain:
  • Contains 1 DDE-1 domain.
  • Contains 1 HTH CENPB-type DNA-binding domain.
  • Contains 1 HTH psq-type DNA-binding domain.
Family:
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with MIR5001: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MIR5001 Gene

Function for MIR5001 Gene

Gene Ontology (GO) - Molecular Function for MIR5001 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with MIR5001: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5001 Gene

Localization for MIR5001 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR5001 Gene

Gene Ontology (GO) - Cellular Components for MIR5001 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MIR5001: view

No data available for Subcellular locations from COMPARTMENTS for MIR5001 Gene

Pathways & Interactions for MIR5001 Gene

SuperPathways for MIR5001 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR5001 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR5001 Gene

Transcripts for MIR5001 Gene

mRNA/cDNA for MIR5001 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5001 Gene

No ASD Table

Relevant External Links for MIR5001 Gene

GeneLoc Exon Structure for
MIR5001
ECgene alternative splicing isoforms for
MIR5001

Expression for MIR5001 Gene

mRNA expression in normal human tissues for MIR5001 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR5001 Gene:

MIR5001
genes like me logo Genes that share expression patterns with MIR5001: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR5001 Gene

Orthologs for MIR5001 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR5001 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIGD1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIGD1 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIGD1 35
  • 40 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 36 (a)
OneToMany
-- 35
  • 31 (a)
OneToMany
-- 35
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia TIGD1 35
  • 53 (a)
OneToOne
Species where no ortholog for MIR5001 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR5001 Gene

ENSEMBL:
Gene Tree for MIR5001 (if available)
TreeFam:
Gene Tree for MIR5001 (if available)

Paralogs for MIR5001 Gene

Paralogs for MIR5001 Gene

genes like me logo Genes that share paralogs with MIR5001: view

Variants for MIR5001 Gene

Sequence variations from dbSNP and Humsavar for MIR5001 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs11683262 -- 232,550,011(+) AGTTC(C/T)ACGTC downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs11689217 -- 232,550,122(+) AGTTT(G/T)AAATA downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs11883815 -- 232,551,797(+) AATAC(A/G)GAGAG intron-variant, upstream-variant-2KB
rs11884935 -- 232,551,902(+) GAGAA(A/G)GTCTT intron-variant, upstream-variant-2KB
rs11899983 -- 232,551,268(+) AATTA(C/T)CTTCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR5001 Gene

Variant ID Type Subtype PubMed ID
nsv3212 CNV deletion 18451855
nsv821918 CNV gain 20364138

Relevant External Links for MIR5001 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5001

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR5001 Gene

Disorders for MIR5001 Gene

Relevant External Links for MIR5001

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR5001

No disorders were found for MIR5001 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5001 Gene

Publications for MIR5001 Gene

  1. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. (PMID: 21911355) FriedlAonder M.R. … Rajewsky N. (Nucleic Acids Res. 2012) 3 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. Enhancing miRNA annotation confidence in miRBase by continuous cross dataset analysis. (PMID: 21558790) Hansen T.B. … Bramsen J.B. (RNA Biol 2011) 3 64
  4. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR5001 Gene

Sources for MIR5001 Gene

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