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Aliases for MIR5000 Gene

Subcategory (RNA class) for MIR5000 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR5000 Gene

  • MicroRNA 5000 2 3 5
  • Hsa-Mir-5000 3

External Ids for MIR5000 Gene

Previous GeneCards Identifiers for MIR5000 Gene

  • GC02U902501
  • GC02P075320

Summaries for MIR5000 Gene

Entrez Gene Summary for MIR5000 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5000 Gene

MIR5000 (MicroRNA 5000) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5000 Gene

Genomics for MIR5000 Gene

Regulatory Elements for MIR5000 Gene

Enhancers for MIR5000 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F075099 0.4 ENCODE 0.4 +9.4 9368 1.8 ZNF263 PKNOX1 MTA2 FEZF1 ZIC2 OSR2 JUND GATA3 FOS CREM TACR1 ENSG00000221638 MOGS ENSG00000270571 MIR5000 PIR31932
GH02F075075 0.9 ENCODE 0.4 -14.2 -14222 1.8 SMARCA4 POLR2A SCRT2 EBF1 MAFK MIR5000 GC02M075053 GC02M075054
GH02F075065 0.7 Ensembl 0.3 -25.3 -25338 0.9 CTCF ZNF654 TRIM22 REST DNMT3B RAD21 HHEX GATA3 SSRP1 JUND ENSG00000221638 GC02M075053 GC02M075054 MIR5000
GH02F075055 0.9 Ensembl ENCODE 0.3 -34.4 -34430 2.7 HDGF PKNOX1 TBL1XR1 MAX ZNF266 BMI1 EBF1 YY1 RELA POLR2A ENSG00000221638 GC02M075053 GC02M075054 MIR5000
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR5000 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR5000 Gene

Chromosome:
2
Start:
75,090,812 bp from pter
End:
75,090,914 bp from pter
Size:
103 bases
Orientation:
Plus strand

Genomic View for MIR5000 Gene

Genes around MIR5000 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5000 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5000 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5000 Gene

Proteins for MIR5000 Gene

Post-translational modifications for MIR5000 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5000 Gene

Domains & Families for MIR5000 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR5000 Gene

Function for MIR5000 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5000 Gene

Localization for MIR5000 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR5000 Gene

Pathways & Interactions for MIR5000 Gene

SuperPathways for MIR5000 Gene

No Data Available

Interacting Proteins for MIR5000 Gene

Gene Ontology (GO) - Biological Process for MIR5000 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR5000 Gene

Transcripts for MIR5000 Gene

mRNA/cDNA for MIR5000 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5000 Gene

No ASD Table

Relevant External Links for MIR5000 Gene

GeneLoc Exon Structure for
MIR5000
ECgene alternative splicing isoforms for
MIR5000

Expression for MIR5000 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR5000 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR5000 Gene:

MIR5000
genes like me logo Genes that share expression patterns with MIR5000: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR5000 Gene

Orthologs for MIR5000 Gene

Evolution for MIR5000 Gene

ENSEMBL:
Gene Tree for MIR5000 (if available)
TreeFam:
Gene Tree for MIR5000 (if available)

No data available for Orthologs for MIR5000 Gene

Paralogs for MIR5000 Gene

No data available for Paralogs for MIR5000 Gene

Variants for MIR5000 Gene

Sequence variations from dbSNP and Humsavar for MIR5000 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs111695084 -- 75,089,506(+) CATCA(C/G)TCTTG intron-variant, upstream-variant-2KB
rs112026117 -- 75,089,195(+) ATGAC(C/T)TTATA intron-variant, upstream-variant-2KB
rs113730637 -- 75,090,690(+) TCTGT(A/T)TGCTC intron-variant, upstream-variant-2KB
rs113933347 -- 75,088,837(+) TCACT(C/T)CCTGC intron-variant, upstream-variant-2KB
rs114154660 -- 75,088,991(+) CTCTC(C/G/T)TGGGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR5000 Gene

Variant ID Type Subtype PubMed ID
nsv1001495 CNV gain 25217958
nsv998145 CNV loss 25217958

Relevant External Links for MIR5000 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5000

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR5000 Gene

Disorders for MIR5000 Gene

Relevant External Links for MIR5000

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR5000

No disorders were found for MIR5000 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5000 Gene

Publications for MIR5000 Gene

  1. MiR-5000-3p, miR-5009-3P and miR-552: potential microRNA biomarkers of side population cells in colon cancer. (PMID: 24898979) Xia Z.S. … Chen G.C. (Oncol. Rep. 2014) 3 64
  2. Enhancing miRNA annotation confidence in miRBase by continuous cross dataset analysis. (PMID: 21558790) Hansen T.B. … Bramsen J.B. (RNA Biol 2011) 3 64
  3. Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia. (PMID: 21606961) Schotte D. … den Boer M.L. (Leukemia 2011) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR5000 Gene

Sources for MIR5000 Gene

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