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Aliases for MIR499A Gene

Subcategory (RNA class) for MIR499A Gene


Quality Score for this RNA gene is


Aliases for MIR499A Gene

  • MicroRNA 499a 2 3 5
  • MicroRNA 499 2 3
  • Hsa-Mir-499a 3
  • Hsa-Mir-499 3
  • Mir-499a 3
  • MIRN499 3
  • MIR499 3

External Ids for MIR499A Gene

ORGUL Members for MIR499A Gene

Previous HGNC Symbols for MIR499A Gene

  • MIRN499
  • MIR499

Previous GeneCards Identifiers for MIR499A Gene

  • GC20U900690
  • GC20P033579

Summaries for MIR499A Gene

Entrez Gene Summary for MIR499A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR499A Gene

MIR499A (MicroRNA 499a) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR499A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR499A Gene

Genomics for MIR499A Gene

Regulatory Elements for MIR499A Gene

Enhancers for MIR499A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H034903 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11 -86.2 -86160 0.8 SMARCE1 TAL1 JUNB DPF2 BATF NR2F2 GATA2 BCL11A EED ZNF512 PIGU MIR499A EDEM2 MMP24-AS1 ACSS2 TP53INP2 GC20P034899 MYH7B
GH20H034921 1.3 Ensembl ENCODE dbSUPER 10.4 -67.9 -67904 2.5 FOXA2 RAD21 RFX5 YY1 ZNF766 RCOR1 FOS DEK CEBPB REST PIGU GSS MIR499A EDEM2 MMP24-AS1 NCOA6 GC20P034899 MYH7B
GH20H035207 1.3 Ensembl ENCODE 10.1 +218.0 218025 1.4 FOXA2 ATF1 ARNT ARID4B SIN3A YY1 TCF12 GTF3C2 GATA2 ZNF143 RBM12 TRPC4AP RBM39 NCOA6 ERGIC3 CPNE1 RPL36P4 EIF6 EDEM2 MMP24-AS1
GH20H034938 1.1 Ensembl ENCODE dbSUPER 11.2 -51.4 -51357 2 ZFHX2 POLR2A HLF MAX MYC EGR2 PIGU MIR499A NCOA6 MYH7B GC20P034899
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR499A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR499A Gene

Genomic Locations for MIR499A Gene
122 bases
Plus strand

Genomic View for MIR499A Gene

Genes around MIR499A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR499A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR499A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR499A Gene

Proteins for MIR499A Gene

Post-translational modifications for MIR499A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR499A Gene

Domains & Families for MIR499A Gene

Gene Families for MIR499A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR499A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR499A Gene

Function for MIR499A Gene

Phenotypes From GWAS Catalog for MIR499A Gene

Gene Ontology (GO) - Molecular Function for MIR499A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20081117
genes like me logo Genes that share ontologies with MIR499A: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR499A Gene

Localization for MIR499A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR499A Gene

Pathways & Interactions for MIR499A Gene

SuperPathways for MIR499A Gene

No Data Available

Interacting Proteins for MIR499A Gene

Gene Ontology (GO) - Biological Process for MIR499A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014883 transition between fast and slow fiber ISS --
GO:0035195 gene silencing by miRNA IDA 20081117
GO:2000727 positive regulation of cardiac muscle cell differentiation IDA 20081117
GO:2000818 negative regulation of myoblast proliferation IDA 20081117
genes like me logo Genes that share ontologies with MIR499A: view

No data available for Pathways by source and SIGNOR curated interactions for MIR499A Gene

Drugs & Compounds for MIR499A Gene

No Compound Related Data Available

Transcripts for MIR499A Gene

mRNA/cDNA for MIR499A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR499A Gene

No ASD Table

Relevant External Links for MIR499A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR499A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR499A Gene

mRNA differential expression in normal tissues according to GTEx for MIR499A Gene

This gene is overexpressed in Pituitary (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of MIR499A Gene:

genes like me logo Genes that share expression patterns with MIR499A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR499A Gene

Orthologs for MIR499A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR499A Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia cfa-mir-499 34
  • 99 (a)
(Pan troglodytes)
Mammalia ptr-mir-499 34
  • 99 (a)
(Bos Taurus)
Mammalia bta-mir-499 34
  • 98 (a)
(Mus musculus)
Mammalia Mir499 34
  • 91 (a)
(Monodelphis domestica)
Mammalia mdo-mir-499 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-499 34
  • 81 (a)
(Gallus gallus)
Aves gga-mir-499 34
  • 69 (a)
(Anolis carolinensis)
Reptilia aca-mir-499 34
  • 75 (a)
(Danio rerio)
Actinopterygii FP015790.1 34
  • 71 (a)
CR847953.1 34
  • 71 (a)
dre-mir-499 34
  • 70 (a)
Species where no ortholog for MIR499A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR499A Gene

Gene Tree for MIR499A (if available)
Gene Tree for MIR499A (if available)

Paralogs for MIR499A Gene

No data available for Paralogs for MIR499A Gene

Variants for MIR499A Gene

Sequence variations from dbSNP and Humsavar for MIR499A Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1001077088 -- 34,990,556(+) GGGAA(C/G)TGAAG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1002631481 -- 34,990,244(+) CCCCC(C/T)AAGTC intron-variant, downstream-variant-500B, upstream-variant-2KB, reference, synonymous-codon
rs1003602086 -- 34,990,553(+) GCAGG(C/G)AAGTG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1003635255 -- 34,988,959(+) CATGC(A/G)CCACC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1003936365 -- 34,990,288(+) GTTCC(A/G)GACGG intron-variant, downstream-variant-500B, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MIR499A Gene

Variant ID Type Subtype PubMed ID
nsv833962 CNV loss 17160897
nsv3362 CNV insertion 18451855
nsv1063673 CNV loss 25217958
nsv1055447 CNV loss 25217958

Relevant External Links for MIR499A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR499A Gene

Disorders for MIR499A Gene

Relevant External Links for MIR499A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR499A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR499A Gene

Publications for MIR499A Gene

  1. Comprehensive review of genetic association studies and meta-analysis on miRNA polymorphisms and rheumatoid arthritis and systemic lupus erythematosus susceptibility. (PMID: 25218914) Fu L … Wu X (Human immunology 2016) 3 60
  2. Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population. (PMID: 26518769) Shen F … Wang M (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 60
  3. Elevated serum miR-93, miR-191, and miR-499 are noninvasive biomarkers for the presence and progression of traumatic brain injury. (PMID: 26756543) Yang T … Wang J (Journal of neurochemistry 2016) 3 60
  4. MicroRNA-499 Rs3746444 polymorphism and biliary atresia. (PMID: 26795543) Shan Y … Xia Q (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2016) 3 60
  5. Regulation of the tumour suppressor PDCD4 by miR-499 and miR-21 in oropharyngeal cancers. (PMID: 26867589) Zhang X … Tran N (BMC cancer 2016) 3 60

Products for MIR499A Gene

Sources for MIR499A Gene

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