Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR499A Gene

Subcategory (RNA class) for MIR499A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR499A Gene

  • MicroRNA 499a 2 3
  • MicroRNA 499 2 3
  • MIRN499 3 6
  • MIR499 3 6
  • Hsa-Mir-499a 3
  • Hsa-Mir-499 3

External Ids for MIR499A Gene

ORGUL Members for MIR499A Gene

Previous HGNC Symbols for MIR499A Gene

  • MIRN499
  • MIR499

Previous GeneCards Identifiers for MIR499A Gene

  • GC20U900690
  • GC20P033579

Summaries for MIR499A Gene

Entrez Gene Summary for MIR499A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR499A Gene

MIR499A (MicroRNA 499a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR499A include ulcerative colitis and familial breast cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR499A Gene

Genomics for MIR499A Gene

Genomic Location for MIR499A Gene

Start:
34,990,376 bp from pter
End:
34,990,497 bp from pter
Size:
122 bases
Orientation:
Plus strand

Genomic View for MIR499A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR499A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR499A Gene

No data available for Regulatory Elements for MIR499A Gene

Proteins for MIR499A Gene

Post-translational modifications for MIR499A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR499A Gene

Domains for MIR499A Gene

Gene Families for MIR499A Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR499A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR499A Gene

Function for MIR499A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR499A Gene

Localization for MIR499A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR499A Gene

Pathways for MIR499A Gene

SuperPathways for MIR499A Gene

No Data Available

Interacting Proteins for MIR499A Gene

Gene Ontology (GO) - Biological Process for MIR499A Gene

None

No data available for Pathways by source for MIR499A Gene

Transcripts for MIR499A Gene

mRNA/cDNA for MIR499A Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR499A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR499A Gene

No ASD Table

Relevant External Links for MIR499A Gene

GeneLoc Exon Structure for
MIR499A
ECgene alternative splicing isoforms for
MIR499A

Expression for MIR499A Gene

mRNA expression in normal human tissues for MIR499A Gene

mRNA differential expression in normal tissues according to GTEx for MIR499A Gene

This gene is overexpressed in Pituitary (5.9).
genes like me logo Genes that share expressions with MIR499A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR499A Gene

Orthologs for MIR499A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR499A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-499 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-499 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-499 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir499 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-499 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-499 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-499 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-499 36
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CR847953.1 36
  • 71 (a)
OneToMany
dre-mir-499 36
  • 70 (a)
OneToMany
FP015790.1 36
  • 71 (a)
OneToMany
Species with no ortholog for MIR499A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR499A Gene

ENSEMBL:
Gene Tree for MIR499A (if available)
TreeFam:
Gene Tree for MIR499A (if available)

Paralogs for MIR499A Gene

No data available for Paralogs for MIR499A Gene

Variants for MIR499A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR499A Gene

Variant ID Type Subtype PubMed ID
nsv912860 CNV Gain 21882294
nsv833962 CNV Loss 17160897
nsv3362 CNV Insertion 18451855

Relevant External Links for MIR499A Gene

HapMap Linkage Disequilibrium report
MIR499A
Human Gene Mutation Database (HGMD)
MIR499A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR499A Gene

Disorders for MIR499A Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR499A Gene in MalaCards »

(2) Diseases for MIR499A Gene including...

genes like me logo Genes that share disorders with MIR499A: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR499A Gene

Publications for MIR499A Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population. (PMID: 19514064) Xu J. … Chen Y. (Hum. Mutat. 2009) 3
  5. Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases. (PMID: 19847796) Catucci I. … Peterlongo P. (Hum. Mutat. 2010) 3

Products for MIR499A Gene

Sources for MIR499A Gene

Back to Top

Content