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Aliases for MIR499A Gene

Subcategory (RNA class) for MIR499A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR499A Gene

  • MicroRNA 499a 2 3 5
  • MicroRNA 499 2 3
  • Hsa-Mir-499a 3
  • Hsa-Mir-499 3
  • Mir-499a 3
  • MIRN499 3
  • MIR499 3

External Ids for MIR499A Gene

ORGUL Members for MIR499A Gene

Previous HGNC Symbols for MIR499A Gene

  • MIRN499
  • MIR499

Previous GeneCards Identifiers for MIR499A Gene

  • GC20U900690
  • GC20P033579

Summaries for MIR499A Gene

Entrez Gene Summary for MIR499A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR499A Gene

MIR499A (MicroRNA 499a) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR499A Gene

Genomics for MIR499A Gene

Regulatory Elements for MIR499A Gene

Enhancers for MIR499A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F035317 1.9 VISTA FANTOM5 Ensembl ENCODE 9.6 +329.3 329279 5.3 PKNOX1 ARID4B SIN3A DMAP1 FEZF1 YY1 SLC30A9 FOS ZNF263 SP3 UQCC1 RBM12 EIF6 FAM83C AAR2 CPNE1 MMP24 NCOA6 FAM83C-AS1 MMP24-AS1
GH20F034903 1.3 FANTOM5 Ensembl ENCODE 11 -86.1 -86077 1.0 TAL1 ZMYM3 GATA2 ADNP EED ETV6 PRDM10 CREM MTA2 HLF PIGU MIR499A EDEM2 MMP24-AS1 ACSS2 TP53INP2 GC20P034899 MYH7B
GH20F035207 1.3 Ensembl ENCODE 10.1 +218.0 218025 1.4 ATF1 ARNT ARID4B SIN3A YY1 GTF3C2 GATA2 ZNF143 DEK MXD4 TRPC4AP RBM12 NCOA6 RPL36P4 CPNE1 EIF6 EDEM2 MMP24-AS1 ENSG00000201151 MIR499A
GH20F035199 1 Ensembl ENCODE 10.1 +209.8 209824 0.8 JUN BHLHE40 CEBPB ELF1 EP300 NR2F2 JUND ZNF316 GATA3 MAFF MMP24 ENSG00000201151 MIR499A NCOA6 GC20M035202 RNA5SP483
GH20F035015 0.7 ENCODE 12.8 +25.4 25399 0.9 GATAD2A SOX5 SOX13 KLF1 SAP130 MTA2 JUNB CEBPG TBX21 GABPA MIR499A GC20M035031 GC20M034988
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR499A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR499A Gene

Chromosome:
20
Start:
34,990,376 bp from pter
End:
34,990,497 bp from pter
Size:
122 bases
Orientation:
Plus strand

Genomic View for MIR499A Gene

Genes around MIR499A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR499A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR499A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR499A Gene

Proteins for MIR499A Gene

Post-translational modifications for MIR499A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR499A Gene

Domains & Families for MIR499A Gene

Gene Families for MIR499A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR499A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR499A Gene

Function for MIR499A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR499A Gene

Localization for MIR499A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR499A Gene

Pathways & Interactions for MIR499A Gene

SuperPathways for MIR499A Gene

No Data Available

Interacting Proteins for MIR499A Gene

Gene Ontology (GO) - Biological Process for MIR499A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR499A Gene

Transcripts for MIR499A Gene

mRNA/cDNA for MIR499A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR499A Gene

No ASD Table

Relevant External Links for MIR499A Gene

GeneLoc Exon Structure for
MIR499A
ECgene alternative splicing isoforms for
MIR499A

Expression for MIR499A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR499A Gene

mRNA differential expression in normal tissues according to GTEx for MIR499A Gene

This gene is overexpressed in Pituitary (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of MIR499A Gene:

MIR499A
genes like me logo Genes that share expression patterns with MIR499A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR499A Gene

Orthologs for MIR499A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR499A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-499 35
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-499 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-499 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir499 35
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-499 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-499 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-499 35
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-499 35
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CR847953.1 35
  • 71 (a)
OneToMany
FP015790.1 35
  • 71 (a)
OneToMany
dre-mir-499 35
  • 70 (a)
OneToMany
Species where no ortholog for MIR499A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR499A Gene

ENSEMBL:
Gene Tree for MIR499A (if available)
TreeFam:
Gene Tree for MIR499A (if available)

Paralogs for MIR499A Gene

No data available for Paralogs for MIR499A Gene

Variants for MIR499A Gene

Sequence variations from dbSNP and Humsavar for MIR499A Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs115357388 -- 34,988,457(+) GTGAG(A/T)GGGTG intron-variant, upstream-variant-2KB
rs11905413 -- 34,988,635(+) GGGCA(A/G)GGTGT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs138164961 -- 34,990,975(+) GTTGA(C/G)CTCTG intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs139288751 -- 34,988,807(+) ATCCC(-/TT)ttttt intron-variant, downstream-variant-500B, upstream-variant-2KB
rs139496637 -- 34,989,545(+) GACTG(A/G)AGCCA intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR499A Gene

Variant ID Type Subtype PubMed ID
nsv1055447 CNV loss 25217958
nsv1063673 CNV loss 25217958
nsv3362 CNV insertion 18451855
nsv833962 CNV loss 17160897

Relevant External Links for MIR499A Gene

Human Gene Mutation Database (HGMD)
MIR499A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR499A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR499A Gene

Disorders for MIR499A Gene

Relevant External Links for MIR499A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR499A

No disorders were found for MIR499A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR499A Gene

Publications for MIR499A Gene

  1. Comprehensive review of genetic association studies and meta-analysis on miRNA polymorphisms and rheumatoid arthritis and systemic lupus erythematosus susceptibility. (PMID: 25218914) Fu L. … Wu X. (Hum. Immunol. 2016) 3 64
  2. Regulation of the tumour suppressor PDCD4 by miR-499 and miR-21 in oropharyngeal cancers. (PMID: 26867589) Zhang X. … Tran N. (BMC Cancer 2016) 3 64
  3. The Associations of Single Nucleotide Polymorphisms in miR196a2, miR-499, and miR-608 With Breast Cancer Susceptibility: A STROBE-Compliant Observational Study. (PMID: 26886638) Dai Z.M. … Dai Z.J. (Medicine (Baltimore) 2016) 3 64
  4. Elevated serum miR-93, miR-191, and miR-499 are noninvasive biomarkers for the presence and progression of traumatic brain injury. (PMID: 26756543) Yang T. … Wang J. (J. Neurochem. 2016) 3 64
  5. Sequence Variation in Mature MicroRNA-499 Confers Unfavorable Prognosis of Lung Cancer Patients Treated with Platinum-Based Chemotherapy. (PMID: 25614447) Qiu F. … Lu J. (Clin. Cancer Res. 2015) 3 64

Products for MIR499A Gene

Sources for MIR499A Gene

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