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Aliases for MIR4999 Gene

Subcategory (RNA class) for MIR4999 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4999 Gene

  • MicroRNA 4999 2 3 5
  • Hsa-Mir-4999 3
  • Mir-4999 3

External Ids for MIR4999 Gene

Previous GeneCards Identifiers for MIR4999 Gene

  • GC19U901577
  • GC19M008456

Summaries for MIR4999 Gene

Entrez Gene Summary for MIR4999 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4999 Gene

MIR4999 (MicroRNA 4999) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4999 Gene

Genomics for MIR4999 Gene

Regulatory Elements for MIR4999 Gene

Enhancers for MIR4999 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G008387 1.1 ENCODE dbSUPER 0.7 +2.0 1993 0.5 INSM2 FEZF1 ZNF2 YY1 ZEB1 ZNF366 SCRT2 FOS CAVIN1 SMAD5 ANGPTL4 MIR4999
GH19G008370 1.5 Ensembl ENCODE dbSUPER 0.4 +18.4 18371 1.5 HDGF PKNOX1 FOXA2 ATF1 ARNT TCF12 GATA2 KLF13 ZNF263 ZNF592 MARCH2 ANGPTL4 MIR4999
GH19G008385 0.8 ENCODE dbSUPER 0.7 +3.6 3560 0.9 PKNOX1 SAP130 PBX2 ZBTB33 CEBPG ZNF600 MNT ANGPTL4 MIR4999
GH19G008373 1.3 ENCODE dbSUPER 0.4 +15.1 15090 1.5 FOXA2 PKNOX1 MLX ARID4B DMAP1 YY1 SP5 NFYC REST ZNF592 LOC100128428 ELAVL1 ZNF177 ZNF558 ZNF699 RAB11B-AS1 ENSG00000269300 ZNF559 HNRNPM MARCH2
GH19G008361 1.6 FANTOM5 ENCODE dbSUPER 0.3 +26.1 26070 3.4 PKNOX1 ARNT AGO1 ZFP64 ARID4B SIN3A YY1 FOS DEK ZNF263 ZNF177 ZNF699 ELAVL1 RAB11B HNRNPM RAB11B-AS1 ANGPTL4 ZNF558 MARCH2 MIR4999
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4999 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4999 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106825 -821 1600 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143

Genomic Location for MIR4999 Gene

Chromosome:
19
Start:
8,389,290 bp from pter
End:
8,389,380 bp from pter
Size:
91 bases
Orientation:
Minus strand

Genomic View for MIR4999 Gene

Genes around MIR4999 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4999 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4999 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4999 Gene

ORGUL Member Location for MIR4999 Gene

ORGUL Member Location for MIR4999 gene

Proteins for MIR4999 Gene

Post-translational modifications for MIR4999 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4999 Gene

Domains & Families for MIR4999 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4999 Gene

Function for MIR4999 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4999 Gene

Localization for MIR4999 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4999 Gene

Pathways & Interactions for MIR4999 Gene

SuperPathways for MIR4999 Gene

No Data Available

Interacting Proteins for MIR4999 Gene

Gene Ontology (GO) - Biological Process for MIR4999 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4999 Gene

Drugs & Compounds for MIR4999 Gene

No Compound Related Data Available

Transcripts for MIR4999 Gene

mRNA/cDNA for MIR4999 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4999 Gene

No ASD Table

Relevant External Links for MIR4999 Gene

GeneLoc Exon Structure for
MIR4999
ECgene alternative splicing isoforms for
MIR4999

Expression for MIR4999 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4999 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4999 Gene:

MIR4999
genes like me logo Genes that share expression patterns with MIR4999: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4999 Gene

Orthologs for MIR4999 Gene

Evolution for MIR4999 Gene

ENSEMBL:
Gene Tree for MIR4999 (if available)
TreeFam:
Gene Tree for MIR4999 (if available)

No data available for Orthologs for MIR4999 Gene

Paralogs for MIR4999 Gene

No data available for Paralogs for MIR4999 Gene

Variants for MIR4999 Gene

Sequence variations from dbSNP and Humsavar for MIR4999 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000080334 -- 8,390,701(+) CCAGA(A/G)CCTAG intron-variant, upstream-variant-2KB
rs1000346951 -- 8,389,922(+) CCCGG(A/T)AATGG intron-variant, upstream-variant-2KB
rs1001965475 -- 8,389,547(+) TCTCG(G/T)CTCAC intron-variant, upstream-variant-2KB
rs1003063002 -- 8,389,332(+) GTGAT(A/G)AATCC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1004450485 -- 8,390,217(+) CCGAG(A/G)GCGAG nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4999 Gene

Variant ID Type Subtype PubMed ID
esv3643614 CNV gain 21293372

Relevant External Links for MIR4999 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4999

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4999 Gene

Disorders for MIR4999 Gene

Relevant External Links for MIR4999

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4999

No disorders were found for MIR4999 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4999 Gene

Publications for MIR4999 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Enhancing miRNA annotation confidence in miRBase by continuous cross dataset analysis. (PMID: 21558790) Hansen T.B. … Bramsen J.B. (RNA Biol 2011) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4999 Gene

Sources for MIR4999 Gene

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