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Aliases for MIR498 Gene

Subcategory (RNA class) for MIR498 Gene


Quality Score for this RNA gene is


Aliases for MIR498 Gene

  • MicroRNA 498 2 3 5
  • Hsa-Mir-498 3
  • Mir-498 3
  • MIRN498 3

External Ids for MIR498 Gene

ORGUL Members for MIR498 Gene

Previous HGNC Symbols for MIR498 Gene

  • MIRN498

Previous GeneCards Identifiers for MIR498 Gene

  • GC19P058871
  • GC19P054177
  • GC19P053675
  • GC19P053681
  • GC19P053691
  • GC19P053719
  • GC19P053759
  • GC19P053792
  • GC19P053799

Summaries for MIR498 Gene

Entrez Gene Summary for MIR498 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR498 Gene

MIR498 (MicroRNA 498) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR498 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR498 Gene

Genomics for MIR498 Gene

Genomic Locations for MIR498 Gene

Genomic Locations for MIR498 Gene
124 bases
Plus strand

Genomic View for MIR498 Gene

Genes around MIR498 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR498 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR498 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR498 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR498 Gene

Proteins for MIR498 Gene

Post-translational modifications for MIR498 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR498 Gene

Domains & Families for MIR498 Gene

Gene Families for MIR498 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR498: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR498 Gene

Function for MIR498 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR498 Gene

Localization for MIR498 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR498 Gene

Pathways & Interactions for MIR498 Gene

SuperPathways for MIR498 Gene

No Data Available

Interacting Proteins for MIR498 Gene

Gene Ontology (GO) - Biological Process for MIR498 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR498 Gene

Drugs & Compounds for MIR498 Gene

No Compound Related Data Available

Transcripts for MIR498 Gene

mRNA/cDNA for MIR498 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR498 Gene

No ASD Table

Relevant External Links for MIR498 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR498 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR498 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR498 Gene:

genes like me logo Genes that share expression patterns with MIR498: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR498 Gene

Orthologs for MIR498 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR498 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-498 34
  • 97 (a)
Species where no ortholog for MIR498 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR498 Gene

Gene Tree for MIR498 (if available)
Gene Tree for MIR498 (if available)

Paralogs for MIR498 Gene

No data available for Paralogs for MIR498 Gene

Variants for MIR498 Gene

Sequence variations from dbSNP and Humsavar for MIR498 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000326097 -- 53,672,642(+) C/A upstream_transcript_variant
rs1000483060 -- 53,672,902(+) C/A upstream_transcript_variant
rs1000659945 -- 53,673,639(+) C/T upstream_transcript_variant
rs1000817035 -- 53,673,858(+) C/T upstream_transcript_variant
rs1001133256 -- 53,672,651(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR498 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv1055718 CNV gain 25217958
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781

Additional Variant Information for MIR498 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR498 Gene

Disorders for MIR498 Gene

Additional Disease Information for MIR498

No disorders were found for MIR498 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR498 Gene

Publications for MIR498 Gene

  1. MiR-498 in esophageal squamous cell carcinoma: clinicopathological impacts and functional interactions. (PMID: 28188753) Islam F … Lam AK (Human pathology 2017) 3 58
  2. Low miR-498 expression levels are associated with poor prognosis in ovarian cancer. (PMID: 26744867) Cong J … Hou J (European review for medical and pharmacological sciences 2015) 3 58
  3. MicroRNA-498 is downregulated in non-small cell lung cancer and correlates with tumor progression. (PMID: 26323905) Wang M … Zhai Y (Journal of cancer research and therapeutics 2015) 3 58
  4. MiR-498 regulated FOXO3 expression and inhibited the proliferation of human ovarian cancer cells. (PMID: 26054675) Liu R … Chen K (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015) 3 58
  5. Downregulation of microRNA-498 in colorectal cancers and its cellular effects. (PMID: 25128149) Gopalan V … Lam AK (Experimental cell research 2015) 3 58

Products for MIR498 Gene

Sources for MIR498 Gene

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