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Aliases for MIR497 Gene

Subcategory (RNA class) for MIR497 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR497 Gene

  • MicroRNA 497 2 3
  • Hsa-Mir-497 3
  • MIRN497 3

External Ids for MIR497 Gene

Previous HGNC Symbols for MIR497 Gene

  • MIRN497

Previous GeneCards Identifiers for MIR497 Gene

  • GC17M006867
  • GC17M006921

Summaries for MIR497 Gene

Entrez Gene Summary for MIR497 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR497 Gene

MIR497 (MicroRNA 497) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR497 include primary peritoneal carcinoma. Among its related pathways are miRNAs involved in DDR.

fRNAdb sequence ontologies for MIR497 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR497

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR497 Gene

Genomics for MIR497 Gene

Genomic Location for MIR497 Gene

Start:
7,017,911 bp from pter
End:
7,018,022 bp from pter
Size:
112 bases
Orientation:
Minus strand

Genomic View for MIR497 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR497 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR497 Gene

ORGUL Member Location for MIR497 Gene

ORGUL Member Location for MIR497 gene

No data available for Regulatory Elements for MIR497 Gene

Proteins for MIR497 Gene

Post-translational modifications for MIR497 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR497 Gene

Domains for MIR497 Gene

Gene Families for MIR497 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR497: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR497 Gene

Function for MIR497 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR497 Gene

Localization for MIR497 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR497 Gene

Pathways for MIR497 Gene

SuperPathways for MIR497 Gene

Superpath Contained pathways
1 miRNAs involved in DDR
genes like me logo Genes that share pathways with MIR497: view

Pathways by source for MIR497 Gene

1 BioSystems pathway for MIR497 Gene

Interacting Proteins for MIR497 Gene

Gene Ontology (GO) - Biological Process for MIR497 Gene

None

Transcripts for MIR497 Gene

fRNAdb Secondary structures for MIR497 Gene

  • hsa-miR-497-3p_MIMAT0004768_Homo_sapiens_miR-497-3p_mature
  • FR190687
  • FR509826
  • hsa-mir-497_MI0003138_Homo_sapiens_miR-497_stem-loop_hairpin

mRNA/cDNA for MIR497 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR497

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR497 Gene

No ASD Table

Relevant External Links for MIR497 Gene

GeneLoc Exon Structure for
MIR497
ECgene alternative splicing isoforms for
MIR497

Expression for MIR497 Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR497 Gene

Orthologs for MIR497 Gene

Evolution for MIR497 Gene

ENSEMBL:
Gene Tree for MIR497 (if available)
TreeFam:
Gene Tree for MIR497 (if available)

No data available for Orthologs for MIR497 Gene

Paralogs for MIR497 Gene

No data available for Paralogs for MIR497 Gene

Variants for MIR497 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR497 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv907634 CNV Loss 21882294
nsv457659 CNV Loss 19166990

Relevant External Links for MIR497 Gene

HapMap Linkage Disequilibrium report
MIR497

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR497 Gene

Disorders for MIR497 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR497 Gene in MalaCards »

(1) Diseases for MIR497 Gene including...

genes like me logo Genes that share disorders with MIR497: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR497 Gene

Publications for MIR497 Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma. (PMID: 18677302) Flavin R.J. … O'Leary J.J. (Mod. Pathol. 2009) 3
  5. miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2. (PMID: 21258880) Zhu W. … Liu P. (Med. Oncol. 2012) 3

Products for MIR497 Gene

Sources for MIR497 Gene

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