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Aliases for MIR497 Gene

Subcategory (RNA class) for MIR497 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR497 Gene

  • MicroRNA 497 2 3 5
  • Hsa-Mir-497 3
  • Mir-497 3
  • MIRN497 3

External Ids for MIR497 Gene

Previous HGNC Symbols for MIR497 Gene

  • MIRN497

Previous GeneCards Identifiers for MIR497 Gene

  • GC17M006867
  • GC17M006921
  • GC17M007019

Summaries for MIR497 Gene

Entrez Gene Summary for MIR497 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR497 Gene

MIR497 (MicroRNA 497) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR497 include Primary Peritoneal Carcinoma. Among its related pathways are Parkinsons Disease Pathway.

fRNAdb sequence ontologies for MIR497 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR497

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR497 Gene

Genomics for MIR497 Gene

Regulatory Elements for MIR497 Gene

Enhancers for MIR497 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G007010 1.8 FANTOM5 ENCODE dbSUPER 0.7 +0.3 309 13.7 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC DVL2 NLGN2 ENSG00000262089 ZBTB4 SNORD10 NEURL4 CNTROB SNORA48 MIR497HG SENP3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR497 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR497 Gene

Chromosome:
17
Start:
7,017,911 bp from pter
End:
7,018,022 bp from pter
Size:
112 bases
Orientation:
Minus strand

Genomic View for MIR497 Gene

Genes around MIR497 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR497 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR497 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR497 Gene

ORGUL Member Location for MIR497 Gene

ORGUL Member Location for MIR497 gene

Proteins for MIR497 Gene

Post-translational modifications for MIR497 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR497 Gene

Domains & Families for MIR497 Gene

Gene Families for MIR497 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR497: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR497 Gene

Function for MIR497 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR497 Gene

Localization for MIR497 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR497 Gene

Pathways & Interactions for MIR497 Gene

SuperPathways for MIR497 Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR497: view

Pathways by source for MIR497 Gene

1 BioSystems pathway for MIR497 Gene

Interacting Proteins for MIR497 Gene

Gene Ontology (GO) - Biological Process for MIR497 Gene

None

No data available for SIGNOR curated interactions for MIR497 Gene

Drugs & Compounds for MIR497 Gene

No Compound Related Data Available

Transcripts for MIR497 Gene

fRNAdb Secondary structures for MIR497 Gene

  • hsa-miR-497-3p_MIMAT0004768_Homo_sapiens_miR-497-3p_mature
  • FR190687
  • FR509826
  • hsa-mir-497_MI0003138_Homo_sapiens_miR-497_stem-loop_hairpin

mRNA/cDNA for MIR497 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR497 Gene

No ASD Table

Relevant External Links for MIR497 Gene

GeneLoc Exon Structure for
MIR497
ECgene alternative splicing isoforms for
MIR497

Expression for MIR497 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR497 Gene:

MIR497
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR497 Gene

Orthologs for MIR497 Gene

Evolution for MIR497 Gene

ENSEMBL:
Gene Tree for MIR497 (if available)
TreeFam:
Gene Tree for MIR497 (if available)

No data available for Orthologs for MIR497 Gene

Paralogs for MIR497 Gene

No data available for Paralogs for MIR497 Gene

Variants for MIR497 Gene

Sequence variations from dbSNP and Humsavar for MIR497 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1001872040 -- 7,017,629(+) GCCTG(C/G)AGCAG intron-variant, nc-transcript-variant, downstream-variant-500B
rs1003037341 -- 7,019,600(+) GGACA(A/C)CCCCC nc-transcript-variant, upstream-variant-2KB
rs1003412908 -- 7,018,673(+) ATCAG(C/T)CCATC intron-variant, upstream-variant-2KB
rs1004447201 -- 7,018,345(+) TCCTG(G/T)GTCCG intron-variant, upstream-variant-2KB
rs1005982782 -- 7,018,550(+) AGGGG(A/G)GCAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR497 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv1121929 CNV deletion 24896259
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv952117 CNV deletion 24416366

Relevant External Links for MIR497 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR497

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR497 Gene

Disorders for MIR497 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR497 Gene - From: GeneCards

Disorder Aliases PubMed IDs
primary peritoneal carcinoma
  • eoppc
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR497

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR497
genes like me logo Genes that share disorders with MIR497: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR497 Gene

Publications for MIR497 Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 1 3 64
  2. Combination of rosuvastatin and probucol inhibits MMP-9 expression via upregulation of miR-497 in cultured HUVECs and apoE knockout mice. (PMID: 26502925) Wang Y.Y. … Li G.P. (J. Thromb. Thrombolysis 2016) 3 64
  3. MicroRNA-497 downregulation contributes to cell proliferation, migration, and invasion of estrogen receptor alpha negative breast cancer by targeting estrogen-related receptor alpha. (PMID: 27456360) Han L. … Han S. (Tumour Biol. 2016) 3 64
  4. microRNA-497 Modulates Breast Cancer Cell Proliferation, Invasion, and Survival by Targeting SMAD7. (PMID: 27303812) Liu J. … Zhang J. (DNA Cell Biol. 2016) 3 64
  5. Expression and function of microRNA-497 in human osteosarcoma. (PMID: 27176490) Liu Q. … Shou F. (Mol Med Rep 2016) 3 64

Products for MIR497 Gene

Sources for MIR497 Gene

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