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Aliases for MIR497 Gene

Subcategory (RNA class) for MIR497 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR497 Gene

  • MicroRNA 497 2 3
  • Mir-497-195 Cluster Host Gene 5
  • Hsa-Mir-497 3
  • MIR497HG 5
  • Mir-497 3
  • MIRN497 3

External Ids for MIR497 Gene

Previous HGNC Symbols for MIR497 Gene

  • MIRN497

Previous GeneCards Identifiers for MIR497 Gene

  • GC17M006867
  • GC17M006921
  • GC17M007019

Summaries for MIR497 Gene

Entrez Gene Summary for MIR497 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR497 Gene

MIR497 (MicroRNA 497) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR497 include Primary Peritoneal Carcinoma. Among its related pathways are Parkinsons Disease Pathway.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR497 Gene

Genomics for MIR497 Gene

Regulatory Elements for MIR497 Gene


Promoters for MIR497 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001804747 259 2001 HDGF BRD4 NFRKB YY1 ZFHX2 ZNF366 PATZ1 PRDM10 ZNF263 ZBTB10

Genomic Location for MIR497 Gene

Chromosome:
17
Start:
7,015,818 bp from pter
End:
7,019,659 bp from pter
Size:
3,842 bases
Orientation:
Minus strand

Genomic View for MIR497 Gene

Genes around MIR497 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR497 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR497 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR497 Gene

Proteins for MIR497 Gene

Post-translational modifications for MIR497 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR497 Gene

Domains & Families for MIR497 Gene

Gene Families for MIR497 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR497: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR497 Gene

Function for MIR497 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR497 Gene

Localization for MIR497 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR497 Gene

Pathways & Interactions for MIR497 Gene

SuperPathways for MIR497 Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR497: view

Pathways by source for MIR497 Gene

1 BioSystems pathway for MIR497 Gene

Interacting Proteins for MIR497 Gene

Gene Ontology (GO) - Biological Process for MIR497 Gene

None

No data available for SIGNOR curated interactions for MIR497 Gene

Transcripts for MIR497 Gene

mRNA/cDNA for MIR497 Gene

(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR497 Gene

No ASD Table

Relevant External Links for MIR497 Gene

GeneLoc Exon Structure for
MIR497
ECgene alternative splicing isoforms for
MIR497

Expression for MIR497 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR497 Gene:

MIR497
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR497 Gene

Orthologs for MIR497 Gene

Evolution for MIR497 Gene

ENSEMBL:
Gene Tree for MIR497 (if available)
TreeFam:
Gene Tree for MIR497 (if available)

No data available for Orthologs for MIR497 Gene

Paralogs for MIR497 Gene

No data available for Paralogs for MIR497 Gene

Variants for MIR497 Gene

Sequence variations from dbSNP and Humsavar for MIR497 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111731181 -- 7,017,431(+) ACCTC(A/G)CTATT intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs113990702 -- 7,019,189(+) GGGGG(A/G)CTCTC intron-variant, upstream-variant-2KB
rs12450517 -- 7,018,644(+) GACCC(A/G)AGCCG intron-variant, upstream-variant-2KB
rs141139896 -- 7,019,962(+) ACCGG(C/G)GGGAA upstream-variant-2KB
rs142120415 -- 7,019,115(+) CAGCT(C/T)CTACC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR497 Gene

Variant ID Type Subtype PubMed ID
nsv952117 CNV deletion 24416366
nsv574322 CNV loss 21841781
nsv457659 CNV loss 19166990
nsv1121929 CNV deletion 24896259
esv2422288 CNV deletion 17116639

Relevant External Links for MIR497 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR497

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR497 Gene

Disorders for MIR497 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR497 Gene - From: GeneCards

Disorder Aliases PubMed IDs
primary peritoneal carcinoma
  • serous surface papillary carcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR497

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR497
genes like me logo Genes that share disorders with MIR497: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR497 Gene

Publications for MIR497 Gene

  1. Role of miR-497 in VEGF-A-mediated cancer cell growth and invasion in non-small cell lung cancer. (PMID: 26485685) Gu A. … Yao M. (Int. J. Biochem. Cell Biol. 2016) 3 64
  2. Combination of rosuvastatin and probucol inhibits MMP-9 expression via upregulation of miR-497 in cultured HUVECs and apoE knockout mice. (PMID: 26502925) Wang Y.Y. … Li G.P. (J. Thromb. Thrombolysis 2016) 3 64
  3. MicroRNA-497 inhibits tumor growth and increases chemosensitivity to 5-fluorouracil treatment by targeting KSR1. (PMID: 26673620) Wang L. … Jiang B.H. (Oncotarget 2016) 3 64
  4. miR-195 in human primary mesenchymal stromal/stem cells regulates proliferation, osteogenesis and paracrine effect on angiogenesis. (PMID: 26683705) Almeida M.I. … Barbosa M.A. (Oncotarget 2016) 3 64
  5. miR-497 suppresses angiogenesis in breast carcinoma by targeting HIF-1I+. (PMID: 26718330) Wu Z. … Liu A. (Oncol. Rep. 2016) 3 64

Products for MIR497 Gene

Sources for MIR497 Gene

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