Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR497 Gene

Subcategory (RNA class) for MIR497 Gene


Quality Score for this RNA gene is


Aliases for MIR497 Gene

  • MicroRNA 497 2 3 5
  • Hsa-Mir-497 3
  • Mir-497 3
  • MIRN497 3

External Ids for MIR497 Gene

Previous HGNC Symbols for MIR497 Gene

  • MIRN497

Previous GeneCards Identifiers for MIR497 Gene

  • GC17M006867
  • GC17M006921
  • GC17M007019

Summaries for MIR497 Gene

Entrez Gene Summary for MIR497 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR497 Gene

MIR497 (MicroRNA 497) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR497 include Primary Peritoneal Carcinoma. Among its related pathways are miRNAs involved in DDR.

fRNAdb sequence ontologies for MIR497 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR497

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR497 Gene

Genomics for MIR497 Gene

Regulatory Elements for MIR497 Gene

Enhancers for MIR497 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIR497 on UCSC Golden Path with GeneCards custom track

Promoters for MIR497 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR497 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR497 Gene

7,017,911 bp from pter
7,018,022 bp from pter
112 bases
Minus strand

Genomic View for MIR497 Gene

Genes around MIR497 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR497 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR497 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR497 Gene

ORGUL Member Location for MIR497 Gene

ORGUL Member Location for MIR497 gene

Proteins for MIR497 Gene

Post-translational modifications for MIR497 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR497 Gene

Domains & Families for MIR497 Gene

Gene Families for MIR497 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR497: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR497 Gene

Function for MIR497 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR497 Gene

Localization for MIR497 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR497 Gene

Pathways & Interactions for MIR497 Gene

SuperPathways for MIR497 Gene

Superpath Contained pathways
1 miRNAs involved in DDR
genes like me logo Genes that share pathways with MIR497: view

Pathways by source for MIR497 Gene

1 BioSystems pathway for MIR497 Gene

Interacting Proteins for MIR497 Gene

Gene Ontology (GO) - Biological Process for MIR497 Gene


No data available for SIGNOR curated interactions for MIR497 Gene

Drugs & Compounds for MIR497 Gene

No Compound Related Data Available

Transcripts for MIR497 Gene

fRNAdb Secondary structures for MIR497 Gene

  • hsa-miR-497-3p_MIMAT0004768_Homo_sapiens_miR-497-3p_mature
  • FR190687
  • FR509826
  • hsa-mir-497_MI0003138_Homo_sapiens_miR-497_stem-loop_hairpin

mRNA/cDNA for MIR497 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR497 Gene

No ASD Table

Relevant External Links for MIR497 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR497 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR497 Gene

Orthologs for MIR497 Gene

Evolution for MIR497 Gene

Gene Tree for MIR497 (if available)
Gene Tree for MIR497 (if available)

No data available for Orthologs for MIR497 Gene

Paralogs for MIR497 Gene

No data available for Paralogs for MIR497 Gene

Variants for MIR497 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR497 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv907634 CNV Loss 21882294
nsv457659 CNV Loss 19166990

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Variation tolerance and Relevant External Links for MIR497 Gene

Disorders for MIR497 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR497 Gene - From: GeneCards

Disorder Aliases PubMed IDs
primary peritoneal carcinoma
  • serous surface papillary carcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR497

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR497: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR497 Gene

Publications for MIR497 Gene

  1. Down-regulation of miR-497 is associated with poor prognosis in renal cancer. (PMID: 25755771) Zhao X. … Du X. (Int J Clin Exp Pathol 2015) 3 67
  2. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 1 3
  3. miR-497 and miR-34a retard lung cancer growth by co-inhibiting cyclin E1 (CCNE1). (PMID: 25909221) Han Z. … Jiang Y. (Oncotarget 2015) 3
  4. MiR-497 promotes metastasis of colorectal cancer cells through Nrdp1 inhibition. (PMID: 25926384) Jiang Y. … Sun S. (Tumour Biol. 2015) 3
  5. miRNA-497 Enhances the Sensitivity of Colorectal Cancer Cells to Neoadjuvant Chemotherapeutic Drug. (PMID: 25929865) Liu L. … Han W. (Curr. Protein Pept. Sci. 2015) 3

Products for MIR497 Gene

Sources for MIR497 Gene