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Aliases for MIR495 Gene

Subcategory (RNA class) for MIR495 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR495 Gene

  • MicroRNA 495 2 3 5
  • Hsa-Mir-495 3
  • Mir-495 3
  • MIRN495 3

External Ids for MIR495 Gene

ORGUL Members for MIR495 Gene

Previous HGNC Symbols for MIR495 Gene

  • MIRN495

Previous GeneCards Identifiers for MIR495 Gene

  • GC14P100821
  • GC14P100912
  • GC14P101504
  • GC14P101505
  • GC14P101569
  • GC14P101611
  • GC14P101636
  • GC14P101670
  • GC14P101711
  • GC14P101752
  • GC14P101810
  • GC14P101950
  • GC14P102141
  • GC14P101247
  • GC14P101852
  • GC14P102105
  • GC14P102339
  • GC14P102512

Summaries for MIR495 Gene

Entrez Gene Summary for MIR495 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR495 Gene

MIR495 (MicroRNA 495) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR495 Gene

Genomics for MIR495 Gene

Regulatory Elements for MIR495 Gene

Enhancers for MIR495 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G101096 1.1 FANTOM5 ENCODE 10.1 +64.6 64593 3.2 CTCF SUZ12 JUN ZIC2 RAD21 ZNF335 GLIS2 ZNF366 GATA2 POLR2A RTL1 LOC105370670 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14G101215 1 ENCODE 9.9 +183.0 182970 2.8 HDGF FOXA2 ARID4B ZNF48 TCF12 GATA2 CAVIN1 ZNF592 SSRP1 ZNF658 DYNC1H1 YY1 SNORD113-3 SNORD113-6 SNORD113-7 SNORD113-4 SNORD113-8 SNORD113-9 MIR543 ENSG00000272444
GH14G101176 0.6 ENCODE 10.1 +143.6 143612 2.0 ZNF680 ZFP3 ZBTB33 REST FOXP2 ZNF507 MIR154 MIR377 MIR496 MIR134 MIR323B MIR485 MIR487A SNORD113-2 SNORD113-3 ENSG00000222185
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR495 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR495 Gene

Chromosome:
14
Start:
101,033,755 bp from pter
End:
101,033,836 bp from pter
Size:
82 bases
Orientation:
Plus strand

Genomic View for MIR495 Gene

Genes around MIR495 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR495 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR495 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR495 Gene

Proteins for MIR495 Gene

Post-translational modifications for MIR495 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR495 Gene

Domains & Families for MIR495 Gene

Gene Families for MIR495 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR495: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR495 Gene

Function for MIR495 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR495 Gene

Localization for MIR495 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR495 Gene

Pathways & Interactions for MIR495 Gene

genes like me logo Genes that share pathways with MIR495: view

Pathways by source for MIR495 Gene

1 BioSystems pathway for MIR495 Gene

Interacting Proteins for MIR495 Gene

Gene Ontology (GO) - Biological Process for MIR495 Gene

None

No data available for SIGNOR curated interactions for MIR495 Gene

Drugs & Compounds for MIR495 Gene

No Compound Related Data Available

Transcripts for MIR495 Gene

mRNA/cDNA for MIR495 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR495 Gene

No ASD Table

Relevant External Links for MIR495 Gene

GeneLoc Exon Structure for
MIR495
ECgene alternative splicing isoforms for
MIR495

Expression for MIR495 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR495 Gene:

MIR495
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR495 Gene

Orthologs for MIR495 Gene

Evolution for MIR495 Gene

ENSEMBL:
Gene Tree for MIR495 (if available)
TreeFam:
Gene Tree for MIR495 (if available)

No data available for Orthologs for MIR495 Gene

Paralogs for MIR495 Gene

No data available for Paralogs for MIR495 Gene

Variants for MIR495 Gene

Sequence variations from dbSNP and Humsavar for MIR495 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000647555 -- 101,032,212(+) TTTTT(C/T)ATGAA downstream-variant-500B, upstream-variant-2KB
rs1000703711 -- 101,032,505(+) TCCCA(C/T)AGCCG downstream-variant-500B, upstream-variant-2KB
rs1000939457 -- 101,034,013(+) CTCTC(A/G)GACAG downstream-variant-500B
rs1001927063 -- 101,033,390(+) AGGAC(C/T)ATCCC upstream-variant-2KB
rs1004701762 -- 101,034,254(+) AAGGG(C/G)ACATG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR495 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Relevant External Links for MIR495 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR495

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR495 Gene

Disorders for MIR495 Gene

Relevant External Links for MIR495

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR495

No disorders were found for MIR495 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR495 Gene

Publications for MIR495 Gene

  1. MicroRNA-495 downregulates FOXC1 expression to suppress cell growth and migration in endometrial cancer. (PMID: 26198045) Xu Y.Y. … Yin L.R. (Tumour Biol. 2016) 3 64
  2. Hsa-miR-495 acts as a tumor suppressor gene in glioma via the negative regulation of MYB. (PMID: 27220777) Zhang B. … Wang W. (Mol Med Rep 2016) 3 64
  3. MicroRNA-495 Regulates Migration and Invasion in Prostate Cancer Cells Via Targeting Akt and mTOR Signaling. (PMID: 27031291) Li J.Z. … Wang Z.M. (Cancer Invest. 2016) 3 64
  4. MiR-495 functions as an adjuvant to radiation therapy by reducing the radiation-induced bystander effect. (PMID: 27697751) Fu J. … Song H. (Acta Biochim. Biophys. Sin. (Shanghai) 2016) 3 64
  5. MicroRNA-495 regulates the proliferation and apoptosis of human umbilical vein endothelial cells by targeting chemokine CCL2. (PMID: 25466836) Liu D. … Han Y.L. (Thromb. Res. 2015) 3 64

Products for MIR495 Gene

Sources for MIR495 Gene

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