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Aliases for MIR494 Gene

Subcategory (RNA class) for MIR494 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR494 Gene

  • MicroRNA 494 2 3 5
  • Hsa-Mir-494 3
  • Mir-494 3
  • MIRN494 3

External Ids for MIR494 Gene

ORGUL Members for MIR494 Gene

Previous HGNC Symbols for MIR494 Gene

  • MIRN494

Previous GeneCards Identifiers for MIR494 Gene

  • GC14P100820
  • GC14P100911
  • GC14P101503
  • GC14P101564
  • GC14P101597
  • GC14P101610
  • GC14P101639
  • GC14P101671
  • GC14P101710
  • GC14P101751
  • GC14P101809
  • GC14P101949
  • GC14P102140
  • GC14P101242
  • GC14P101850
  • GC14P102103
  • GC14P102337
  • GC14P102509
  • GC14P102689

Summaries for MIR494 Gene

Entrez Gene Summary for MIR494 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR494 Gene

MIR494 (MicroRNA 494) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR494 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR494 Gene

Genomics for MIR494 Gene

Genomic Location for MIR494 Gene

Chromosome:
14
Start:
101,029,634 bp from pter
End:
101,029,714 bp from pter
Size:
81 bases
Orientation:
Plus strand

Genomic View for MIR494 Gene

Genes around MIR494 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR494 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR494 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR494 Gene

No data available for Regulatory Elements for MIR494 Gene

Proteins for MIR494 Gene

Post-translational modifications for MIR494 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR494 Gene

Domains & Families for MIR494 Gene

Gene Families for MIR494 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR494: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR494 Gene

Function for MIR494 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR494
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR494 Gene

Localization for MIR494 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR494 Gene

Pathways & Interactions for MIR494 Gene

SuperPathways for MIR494 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR494: view

Pathways by source for MIR494 Gene

1 KEGG pathway for MIR494 Gene

Interacting Proteins for MIR494 Gene

Gene Ontology (GO) - Biological Process for MIR494 Gene

None

No data available for SIGNOR curated interactions for MIR494 Gene

Drugs & Compounds for MIR494 Gene

No Compound Related Data Available

Transcripts for MIR494 Gene

mRNA/cDNA for MIR494 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR494
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR494 Gene

No ASD Table

Relevant External Links for MIR494 Gene

GeneLoc Exon Structure for
MIR494
ECgene alternative splicing isoforms for
MIR494

Expression for MIR494 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR494 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR494 Gene:

MIR494
genes like me logo Genes that share expression patterns with MIR494: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR494 Gene

Orthologs for MIR494 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR494 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-494 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-494 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir494 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-494 34
  • 93 (a)
OneToOne
Species where no ortholog for MIR494 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR494 Gene

ENSEMBL:
Gene Tree for MIR494 (if available)
TreeFam:
Gene Tree for MIR494 (if available)

Paralogs for MIR494 Gene

No data available for Paralogs for MIR494 Gene

Variants for MIR494 Gene

Sequence variations from dbSNP and Humsavar for MIR494 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000534079 -- 101,027,870(+) GGGCA(A/T)GTACC upstream-variant-2KB
rs1001218964 -- 101,029,491(+) GACAC(A/G)CAAAT upstream-variant-2KB
rs1002207888 -- 101,029,005(+) GCATT(A/G)AGTGG upstream-variant-2KB
rs1002427291 -- 101,028,812(+) CTCTG(C/T)TGAGA upstream-variant-2KB
rs1002486330 -- 101,028,301(+) GTCCT(C/T)GGCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR494 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
esv3635523 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv1426 CNV insertion 18451855
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Relevant External Links for MIR494 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR494

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR494 Gene

Disorders for MIR494 Gene

Relevant External Links for MIR494

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR494

No disorders were found for MIR494 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR494 Gene

Publications for MIR494 Gene

  1. MicroRNA-494 Activation Suppresses Bone Marrow Stromal Cell-Mediated Drug Resistance in Acute Myeloid Leukemia Cells. (PMID: 27696394) Tian C … Zhang Y (Journal of cellular physiology 2017) 3 60
  2. [Effects of microRNA-494 on the fiber type-specific skeletal myogenesis in human induced pluripotent stem cells]. (PMID: 27181718) Iwasaki H … Imamura T (Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2016) 3 60
  3. Tumor-suppressor NFκB2 p100 interacts with ERK2 and stabilizes PTEN mRNA via inhibition of miR-494. (PMID: 26686085) Wang Y … Huang C (Oncogene 2016) 3 60
  4. Dicer Elicits Paclitaxel Chemosensitization and Suppresses Cancer Stemness in Breast Cancer by Repressing AXL. (PMID: 27216190) Chang TY … Su JL (Cancer research 2016) 3 60
  5. TGF-β3-induced miR-494 inhibits macrophage polarization via suppressing PGE2 secretion in mesenchymal stem cells. (PMID: 27149081) Zhao G … Hou Y (FEBS letters 2016) 3 60

Products for MIR494 Gene

Sources for MIR494 Gene

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