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Aliases for MIR494 Gene

Subcategory (RNA class) for MIR494 Gene


Quality Score for this RNA gene is


Aliases for MIR494 Gene

  • MicroRNA 494 2 3
  • Hsa-Mir-494 3
  • Mir-494 3
  • MIRN494 3

External Ids for MIR494 Gene

ORGUL Members for MIR494 Gene

Previous HGNC Symbols for MIR494 Gene

  • MIRN494

Previous GeneCards Identifiers for MIR494 Gene

  • GC14P100820
  • GC14P100911
  • GC14P101503
  • GC14P101564
  • GC14P101597
  • GC14P101610
  • GC14P101639
  • GC14P101671
  • GC14P101710
  • GC14P101751
  • GC14P101809
  • GC14P101949
  • GC14P102140
  • GC14P101242

Summaries for MIR494 Gene

Entrez Gene Summary for MIR494 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR494 Gene

MIR494 (MicroRNA 494) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR494 Gene

Genomics for MIR494 Gene

Genomic Location for MIR494 Gene

101,029,611 bp from pter
101,029,719 bp from pter
109 bases
Plus strand

Genomic View for MIR494 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR494 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR494 Gene

No data available for Regulatory Elements for MIR494 Gene

Proteins for MIR494 Gene

Post-translational modifications for MIR494 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR494 Gene

Domains & Families for MIR494 Gene

Gene Families for MIR494 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR494: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR494 Gene

Function for MIR494 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR494 Gene

Localization for MIR494 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR494 Gene

Pathways & Interactions for MIR494 Gene

SuperPathways for MIR494 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR494: view

Pathways by source for MIR494 Gene

1 KEGG pathway for MIR494 Gene

Interacting Proteins for MIR494 Gene

Gene Ontology (GO) - Biological Process for MIR494 Gene


No data available for SIGNOR curated interactions for MIR494 Gene

Drugs & Compounds for MIR494 Gene

No Compound Related Data Available

Transcripts for MIR494 Gene

mRNA/cDNA for MIR494 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR494 Gene

No ASD Table

Relevant External Links for MIR494 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR494 Gene

mRNA expression in normal human tissues for MIR494 Gene

genes like me logo Genes that share expression patterns with MIR494: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR494 Gene

Orthologs for MIR494 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR494 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-494 36
  • 93 (a)
(Canis familiaris)
Mammalia cfa-mir-494 36
  • 100 (a)
(Mus musculus)
Mammalia Mir494 36
  • 94 (a)
(Pan troglodytes)
Mammalia ptr-mir-494 36
  • 100 (a)
Species with no ortholog for MIR494:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR494 Gene

Gene Tree for MIR494 (if available)
Gene Tree for MIR494 (if available)

Paralogs for MIR494 Gene

No data available for Paralogs for MIR494 Gene

Variants for MIR494 Gene

Sequence variations from dbSNP and Humsavar for MIR494 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs73353149 -- 101,027,744(+) TTTCT(A/C)ACAGG upstream-variant-2KB
rs74080302 -- 101,027,844(+) GGGAA(G/T)GGAGT upstream-variant-2KB
rs75416936 -- 101,027,917(+) CTGAC(A/C/T)TACCC upstream-variant-2KB
rs77011336 -- 101,028,043(+) CACCA(A/G)TTTGG upstream-variant-2KB
rs116463535 -- 101,028,047(+) AGTTT(A/G)GAAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR494 Gene

Variant ID Type Subtype PubMed ID
nsv1426 CNV Insertion 18451855

Relevant External Links for MIR494 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR494 Gene

Disorders for MIR494 Gene

Relevant External Links for MIR494

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR494: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR494 Gene

Publications for MIR494 Gene

  1. MicroRNA-494 is a master epigenetic regulator of multiple invasion-suppressor microRNAs by targeting ten eleven translocation 1 in invasive human hepatocellular carcinoma tumors. (PMID: 25820676) Chuang K.H. … Barry C.T. (Hepatology 2015) 67
  2. MicroRNA-494 inhibits the growth and angiogenesis-regulating potential of mesenchymal stem cells. (PMID: 25660325) Chen S. … Hou Y. (FEBS Lett. 2015) 67
  3. Upregulation of miR-494 Inhibits Cell Growth and Invasion and Induces Cell Apoptosis by Targeting Cleft Lip and Palate Transmembrane 1-Like in Esophageal Squamous Cell Carcinoma. (PMID: 25480402) Zhang R. … Zhao G. (Dig. Dis. Sci. 2015) 67
  4. Overexpression of secretagogin inhibits cell apoptosis and induces chemoresistance in small cell lung cancer under the regulation of miR-494. (PMID: 25226615) Bai Y. … Guo L. (Oncotarget 2014) 67
  5. MicroRNA expression as risk biomarker of breast cancer metastasis: a pilot retrospective case-cohort study. (PMID: 25277099) Marino A.L. … Marques M.M. (BMC Cancer 2014) 67

Products for MIR494 Gene

Sources for MIR494 Gene

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