microRNA 494 (Previous symbol: MIRN494 )
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Aliasesfor MIR494 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Subcategory (RNA class): miRNAQuality score for this RNA gene is 19.2 Aliases MicroRNA 494 1 2 MIRN4941 2 Hsa-Mir-4941 Mir-4941
External Ids: HGNC: 32084 1 Entrez Gene: 574452 2 Ensembl: ENSG00000194717 7 Export aliases for MIR494 gene to outside databases Previous GC identifers: GC14P100820 GC14P100911 GC14P101503 GC14P101564 GC14P101597 GC14P101610 GC14P101639 GC14P101671 GC14P101710 GC14P101751
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Summariesfor MIR494 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MIR494 : microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009) fRNAdb sequence ontologies for MIR494 - the ORGUL cluster for this gene includes several descriptions: microRNA mir-154 - miRNA - Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.pre_miRNA - The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.View fRNAdb secondary structures for MIR494
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Genomic Viewsfor MIR494 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for MIR494 Other transcription factors Search SABiosciences Chromatin IP Primers for MIR494 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR494
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 14q32.31 Ensembl cytogenetic band: 14q32.31 HGNC cytogenetic band: 14q32.31 MIR494 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14P101809: view genomic region (via miRBase )
(about GC identifiers )
Start:
101,495,971 bp from pter
End:
101,496,051 bp from pter
Size:
81 bases
Orientation:
plus strand
ORGUL member locations:Legend (see complete legend)
hsa-mir-494_hairpin
FR0306830
RF00641
hsa-miR-494_mature
FR0132731
FR0302191
101495970 101496011 101496051 chr14
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Proteinsfor MIR494 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB: --
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Protein
Domains / Familiesfor MIR494 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section --
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Functionfor MIR494 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section
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Pathways & Interactionsfor MIR494 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR494
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Drugs & Compoundsfor MIR494 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MIR494 Search CenterWatch for drugs/clinical trials and news about MIR494
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Transcriptsfor MIR494 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section 1 fRNAdb Secondary structure: 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000349529(miRNA) GeneLoc Exon Structure
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Expression for MIR494 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section Expression evidence for MIR494:miRBase
MIR494 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for MIR494 Primer Products: Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MIR494 Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR494 Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR494
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Orthologsfor MIR494 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
--
ENSEMBL Gene Tree for MIR494 (if available)TreeFam Gene Tree for MIR494 (if available)
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Paralogsfor MIR494 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MIR494 gene MIR656 2 MIR381 2 MIR154 2 MIR655 2 MIR410 2 MIR539 2 MIR409 2 MIR487A 2 MIR323A 2 MIR1185-2 2 MIR323B 2 MIR300 2 MIR377 2 MIR487B 2 MIR1185-1 2 MIR496 2 MIR369 2
MIR494 for paralogs About GeneDecksing
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Genomic Variantsfor MIR494 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 14 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MIR494 (101495971 - 101496051 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MIR494: --
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor MIR494 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MIR494 for disorders About GeneDecksing 2 diseases for MIR494 : About MalaCards cholangiocarcinoma lung cancer Export disorders for MIR494 gene to outside databases
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Publicationsfor MIR494 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MIR494 gene, integrated from 9 sources (see all 15 ): (articles sorted by number of sources associating them with MIR494) Utopia : connect your pdf to the dynamic world of online information
Coordinated effects of microRNA-494 induce G_2/M arres t in human cholangiocarcinoma. (PubMed id 22785131) 1 Yamanaka S....Selaru F.M. (2012) MicroRNA-494 suppresses cell proliferation and induce s senescence in A549 lung cancer cells. (PubMed id 22151897) 1 Ohdaira H....Yoshida K. (2012) MicroRNA-494 reduces ATF3 expression and promotes AKI. (PubMed id 23160513) 1 Lan Y.F....Lin H. (2012) MiR-494 is regulated by ERK1/2 and modulates TRAIL-ind uced apoptosis in non-small-cell lung cancer through BIM down-regulation. (PubMed id 23012423) 1 Romano G....Croce C.M. (2012) Competitive regulation of nucleolin expression by HuR and miR-494. (PubMed id 21859890) 1 Tominaga K....Gorospe M. (2011) MicroRNA-494 downregulates KIT and inhibits gastrointe stinal stromal tumor cell proliferation. (PubMed id 22042971) 1 Kim W.K....Kim H. (2011) MicroRNA down-regulated in human cholangiocarcinoma c ontrol cell cycle through multiple targets involved in the G1/S checkpoint. (PubMed id 21809359) 1 Olaru A.V....Selaru F.M. (2011) Synergistic post-transcriptional regulation of the Cys tic Fibrosis Transmembrane conductance Regulator (CFTR) by miR-101 and miR-494 s pecific binding. (PubMed id 22028919) 1 Megiorni F....Pizzuti A. (2011) TEL-AML1 regulation of survivin and apoptosis via miR NA-494 and miRNA-320a. (PubMed id 20807887) 1 Diakos C....Wiemels J.L. (2010) A mammalian microRNA expression atlas based on small RNA library sequencing. (PubMed id 17604727) 1 Landgraf P....Tuschl T. (2007)
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External Searches for MIR494 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MIR494 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MIR494 gene
(According to HUGE )
About This Section --
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Specialized Databases showing MIR494 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MIR494 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MIR494 gene: Search GeneIP for patents involving MIR494 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MIR494 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIR494 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIR494 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR494 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MIR494 Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR494 Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR494
Search Tocris compounds for MIR494
Search ThermoFisher Antibodies for MIR494
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR494
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