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Aliases for MIR493 Gene

Subcategory (RNA class) for MIR493 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR493 Gene

  • MicroRNA 493 2 3 5
  • Hsa-Mir-493 3
  • Mir-493 3
  • MIRN493 3

External Ids for MIR493 Gene

ORGUL Members for MIR493 Gene

Previous HGNC Symbols for MIR493 Gene

  • MIRN493

Previous GeneCards Identifiers for MIR493 Gene

  • GC14P100406
  • GC14P101335
  • GC14P101216
  • GC14P101797

Summaries for MIR493 Gene

Entrez Gene Summary for MIR493 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR493 Gene

MIR493 (MicroRNA 493) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR493 Gene

Genomics for MIR493 Gene

Regulatory Elements for MIR493 Gene

Enhancers for MIR493 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIR493 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR493 Gene

Chromosome:
14
Start:
100,869,055 bp from pter
End:
100,869,164 bp from pter
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR493 Gene

Genes around MIR493 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR493 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR493 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR493 Gene

Proteins for MIR493 Gene

Post-translational modifications for MIR493 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR493 Gene

Domains & Families for MIR493 Gene

Gene Families for MIR493 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR493: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR493 Gene

Function for MIR493 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR493 Gene

Localization for MIR493 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR493 Gene

Pathways & Interactions for MIR493 Gene

SuperPathways for MIR493 Gene

No Data Available

Interacting Proteins for MIR493 Gene

Gene Ontology (GO) - Biological Process for MIR493 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR493 Gene

Drugs & Compounds for MIR493 Gene

No Compound Related Data Available

Transcripts for MIR493 Gene

mRNA/cDNA for MIR493 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR493 Gene

No ASD Table

Relevant External Links for MIR493 Gene

GeneLoc Exon Structure for
MIR493
ECgene alternative splicing isoforms for
MIR493

Expression for MIR493 Gene

mRNA expression in normal human tissues for MIR493 Gene

genes like me logo Genes that share expression patterns with MIR493: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR493 Gene

Orthologs for MIR493 Gene

Evolution for MIR493 Gene

ENSEMBL:
Gene Tree for MIR493 (if available)
TreeFam:
Gene Tree for MIR493 (if available)

No data available for Orthologs for MIR493 Gene

Paralogs for MIR493 Gene

No data available for Paralogs for MIR493 Gene

Variants for MIR493 Gene

Sequence variations from dbSNP and Humsavar for MIR493 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1320440 -- 100,867,363(+) GTGCA(C/T)GTGTG upstream-variant-2KB
rs8021312 -- 100,867,309(+) TGTTA(C/T)GGGAG upstream-variant-2KB
rs10142971 -- 100,868,418(+) GCCAG(C/T)GAGGT upstream-variant-2KB
rs10130356 -- 100,868,082(+) GTGGC(A/G)CTGGC upstream-variant-2KB
rs12881023 -- 100,868,408(+) CGATT(G/T)GTTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR493 Gene

Variant ID Type Subtype PubMed ID
nsv902240 CNV Loss 21882294
nsv509549 CNV Insertion 20534489
nsv902241 CNV Loss 21882294
esv2456141 CNV Deletion 19546169

Relevant External Links for MIR493 Gene

HapMap Linkage Disequilibrium report
MIR493

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR493 Gene

Disorders for MIR493 Gene

Relevant External Links for MIR493

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR493

No disorders were found for MIR493 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR493 Gene

Publications for MIR493 Gene

  1. MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells. (PMID: 24533778) Sakai H. … Okamoto K. (Cancer Sci. 2014) 3 67
  2. MicroRNA-493 suppresses tumor growth, invasion and metastasis of lung cancer by regulating E2F1. (PMID: 25105419) Gu Y. … He Z. (PLoS ONE 2014) 3
  3. Tumor suppressor microRNA-493 decreases cell motility and migration ability in human bladder cancer cells by downregulating RhoC and FZD4. (PMID: 22057916) Ueno K. … Dahiya R. (Mol. Cancer Ther. 2012) 3
  4. miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver. (PMID: 22373578) Okamoto K. … Nakagama H. (EMBO J. 2012) 3
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3

Products for MIR493 Gene

Sources for MIR493 Gene

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