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Aliases for MIR493 Gene

Subcategory (RNA class) for MIR493 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR493 Gene

  • MicroRNA 493 2 3 5
  • Hsa-Mir-493 3
  • Mir-493 3
  • MIRN493 3

External Ids for MIR493 Gene

ORGUL Members for MIR493 Gene

Previous HGNC Symbols for MIR493 Gene

  • MIRN493

Previous GeneCards Identifiers for MIR493 Gene

  • GC14P100406
  • GC14P101335
  • GC14P101216
  • GC14P101797
  • GC14P102090
  • GC14P102325

Summaries for MIR493 Gene

Entrez Gene Summary for MIR493 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR493 Gene

MIR493 (MicroRNA 493) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR493 Gene

Genomics for MIR493 Gene

Regulatory Elements for MIR493 Gene

Enhancers for MIR493 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F100833 0.8 Ensembl ENCODE 11.2 -30.3 -30265 10.6 BCOR ESRRA ZMYM3 ZIC2 TEAD3 ZFHX2 SCRT2 FOS NFE2 ZNF600 MEG3 MIR493 MIR337 MIR127 MIR431 MIR433 MIR136 RTL1 SNORD112 MIR370
GH14F100819 1 FANTOM5 ENCODE 10.7 -42.5 -42525 13.4 PKNOX1 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 CBX5 DLK1 MEG3 MIR493 MIR337 MIR431 RTL1 MIR127 MIR136 MIR433 SNORD112
GH14F100788 0.9 ENCODE 10.6 -78.3 -78323 5.5 HDAC1 ATF1 NFRKB RAD21 GATA2 CREM CEBPB NR2F2 MBD2 TFDP1 DLK1 MIR493 MIR337 MIR127 MIR136 MIR431 MIR433 RTL1 BEGAIN MEG3
GH14F100691 1 FANTOM5 Ensembl ENCODE 10 -175.6 -175578 4.2 ELF3 TBP MLX INSM2 KLF17 NFXL1 ZNF48 RAD21 DNMT3B RARA DLK1 MIR493 MIR337 MIR136 RTL1 MIR127 MIR431 MIR433 LINC00523 LOC105370668
GH14F100688 1.2 Ensembl ENCODE 10 -180.1 -180135 1.4 GATAD2A ELF3 KLF1 ZIC2 RARA ZFHX2 JUND ZNF366 SCRT2 SMAD4 DLK1 MIR493 MIR127 MIR431 MIR433 MIR337 RTL1 MIR136 LOC105370668 LOC105370669
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR493 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR493 Gene

Chromosome:
14
Start:
100,869,060 bp from pter
End:
100,869,148 bp from pter
Size:
89 bases
Orientation:
Plus strand

Genomic View for MIR493 Gene

Genes around MIR493 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR493 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR493 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR493 Gene

Proteins for MIR493 Gene

Post-translational modifications for MIR493 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR493 Gene

Domains & Families for MIR493 Gene

Gene Families for MIR493 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR493: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR493 Gene

Function for MIR493 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR493 Gene

Localization for MIR493 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR493 Gene

Pathways & Interactions for MIR493 Gene

SuperPathways for MIR493 Gene

No Data Available

Interacting Proteins for MIR493 Gene

Gene Ontology (GO) - Biological Process for MIR493 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR493 Gene

Transcripts for MIR493 Gene

mRNA/cDNA for MIR493 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR493 Gene

No ASD Table

Relevant External Links for MIR493 Gene

GeneLoc Exon Structure for
MIR493
ECgene alternative splicing isoforms for
MIR493

Expression for MIR493 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR493 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR493 Gene:

MIR493
genes like me logo Genes that share expression patterns with MIR493: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR493 Gene

Orthologs for MIR493 Gene

Evolution for MIR493 Gene

ENSEMBL:
Gene Tree for MIR493 (if available)
TreeFam:
Gene Tree for MIR493 (if available)

No data available for Orthologs for MIR493 Gene

Paralogs for MIR493 Gene

No data available for Paralogs for MIR493 Gene

Variants for MIR493 Gene

Sequence variations from dbSNP and Humsavar for MIR493 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10130356 -- 100,868,082(+) GTGGC(A/G)CTGGC upstream-variant-2KB
rs10142971 -- 100,868,418(+) GCCAG(C/T)GAGGT upstream-variant-2KB
rs111333314 -- 100,867,397(+) CTGTG(C/T)GTGCC upstream-variant-2KB
rs112646915 -- 100,869,431(+) CTGCC(A/G)GAGTT downstream-variant-500B
rs113065749 -- 100,869,179(+) TGTGA(A/G)TGCAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR493 Gene

Variant ID Type Subtype PubMed ID
esv2456141 CNV deletion 19546169
esv3635518 CNV gain 21293372
nsv509549 CNV insertion 20534489

Relevant External Links for MIR493 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR493

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR493 Gene

Disorders for MIR493 Gene

Relevant External Links for MIR493

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR493

No disorders were found for MIR493 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR493 Gene

Publications for MIR493 Gene

  1. miR-493 mediated DKK1 down-regulation confers proliferation, invasion and chemo-resistance in gastric cancer cells. (PMID: 26799283) Jia X. … He Z. (Oncotarget 2016) 3 64
  2. MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells. (PMID: 24533778) Sakai H. … Okamoto K. (Cancer Sci. 2014) 3 64
  3. MicroRNA-493 suppresses tumor growth, invasion and metastasis of lung cancer by regulating E2F1. (PMID: 25105419) Gu Y. … He Z. (PLoS ONE 2014) 3 64
  4. Tumor suppressor microRNA-493 decreases cell motility and migration ability in human bladder cancer cells by downregulating RhoC and FZD4. (PMID: 22057916) Ueno K. … Dahiya R. (Mol. Cancer Ther. 2012) 3 64
  5. miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver. (PMID: 22373578) Okamoto K. … Nakagama H. (EMBO J. 2012) 3 64

Products for MIR493 Gene

Sources for MIR493 Gene

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