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Aliases for MIR493 Gene

Subcategory (RNA class) for MIR493 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR493 Gene

  • MicroRNA 493 2 3
  • Hsa-Mir-493 3
  • MIRN493 3

External Ids for MIR493 Gene

ORGUL Members for MIR493 Gene

Previous HGNC Symbols for MIR493 Gene

  • MIRN493

Previous GeneCards Identifiers for MIR493 Gene

  • GC14P100406
  • GC14P101335

Summaries for MIR493 Gene

Entrez Gene Summary for MIR493 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR493 Gene

MIR493 (MicroRNA 493) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR493 Gene

Genomics for MIR493 Gene

Genomic Location for MIR493 Gene

Start:
100,869,055 bp from pter
End:
100,869,164 bp from pter
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR493 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR493 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR493 Gene

No data available for Regulatory Elements for MIR493 Gene

Proteins for MIR493 Gene

Post-translational modifications for MIR493 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR493 Gene

Domains for MIR493 Gene

Gene Families for MIR493 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR493: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR493 Gene

Function for MIR493 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR493 Gene

Localization for MIR493 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR493 Gene

Pathways for MIR493 Gene

SuperPathways for MIR493 Gene

No Data Available

Interacting Proteins for MIR493 Gene

Gene Ontology (GO) - Biological Process for MIR493 Gene

None

No data available for Pathways by source for MIR493 Gene

Transcripts for MIR493 Gene

mRNA/cDNA for MIR493 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR493

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR493 Gene

No ASD Table

Relevant External Links for MIR493 Gene

GeneLoc Exon Structure for
MIR493
ECgene alternative splicing isoforms for
MIR493

Expression for MIR493 Gene

mRNA expression in normal human tissues for MIR493 Gene

genes like me logo Genes that share expressions with MIR493: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR493 Gene

Orthologs for MIR493 Gene

Evolution for MIR493 Gene

ENSEMBL:
Gene Tree for MIR493 (if available)
TreeFam:
Gene Tree for MIR493 (if available)

No data available for Orthologs for MIR493 Gene

Paralogs for MIR493 Gene

No data available for Paralogs for MIR493 Gene

Variants for MIR493 Gene

Sequence variations from dbSNP and Humsavar for MIR493 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1320440 -- 100,867,363(+) GTGCA(C/T)GTGTG upstream-variant-2KB
rs8021312 -- 100,867,309(+) TGTTA(C/T)GGGAG upstream-variant-2KB
rs10130356 -- 100,868,082(+) GTGGC(A/G)CTGGC upstream-variant-2KB
rs10142971 -- 100,868,418(+) GCCAG(C/T)GAGGT upstream-variant-2KB
rs11620960 -- 100,867,624(+) CTTCC(C/T)GGAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR493 Gene

Variant ID Type Subtype PubMed ID
nsv902240 CNV Loss 21882294
nsv509549 CNV Insertion 20534489
nsv902241 CNV Loss 21882294
esv2456141 CNV Deletion 19546169

Relevant External Links for MIR493 Gene

HapMap Linkage Disequilibrium report
MIR493

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR493 Gene

Disorders for MIR493 Gene

No disorders were found for MIR493 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR493 Gene

Publications for MIR493 Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3
  2. Identification of clustered microRNAs using an ab initio prediction method. (PMID: 16274478) Sewer A. … Zavolan M. (BMC Bioinformatics 2005) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  5. MicroRNA expression in ACTH-producing pituitary tumors: up-regulation of microRNA-122 and -493 in pituitary carcinomas. (PMID: 20960104) Stilling G. … Lloyd R.V. (Endocrine 2010) 3

Products for MIR493 Gene

Sources for MIR493 Gene

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