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Aliases for MIR492 Gene

Subcategory (RNA class) for MIR492 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR492 Gene

  • MicroRNA 492 2 3 5
  • Hsa-Mir-492 3
  • MIRN492 3

External Ids for MIR492 Gene

ORGUL Members for MIR492 Gene

Previous HGNC Symbols for MIR492 Gene

  • MIRN492

Previous GeneCards Identifiers for MIR492 Gene

  • GC12P093753
  • GC12P095229
  • GC12P095230
  • GC12P095232
  • GC12P095234
  • GC12P095236

Summaries for MIR492 Gene

Entrez Gene Summary for MIR492 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR492 Gene

MIR492 (MicroRNA 492) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR492 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR492 Gene

Genomics for MIR492 Gene

GeneHancer (GH) Regulatory Elements for MIR492 Gene

Promoters and enhancers for MIR492 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I094832 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 550.8 -1.0 -1024 1.5 INSM2 MZF1 FEZF1 ZNF2 ZNF335 ZSCAN5C ZNF391 ZNF202 ZNF362 CEBPB GC12P094845 GC12P094846 KRT19P2 MIR492 NR2C1 ENSG00000258365 USP44 ENSG00000271382 CEP83 GC12M094805
GH12I094792 Enhancer 0.5 Ensembl 11.9 -41.6 -41643 0.7 HLF CEBPA MAX MNT KDM1A CEBPG MYC KRT19P2 MIR492 GC12M094805 GC12M094666
GH12I094972 Enhancer 0.3 ENCODE 10 +139.0 138974 1.7 FOS NDUFA12 FGD6 KRT19P2 MIR492 TMCC3 ENSG00000258365 GC12M094957 LOC105369915
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR492 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR492 Gene

Genomic Locations for MIR492 Gene
chr12:94,834,398-94,834,513
(GRCh38/hg38)
Size:
116 bases
Orientation:
Plus strand
chr12:95,228,174-95,228,289
(GRCh37/hg19)

Genomic View for MIR492 Gene

Genes around MIR492 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR492 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR492 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR492 Gene

Proteins for MIR492 Gene

Post-translational modifications for MIR492 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR492 Gene

Domains & Families for MIR492 Gene

Gene Families for MIR492 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR492: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR492 Gene

Function for MIR492 Gene

Phenotypes From GWAS Catalog for MIR492 Gene

Gene Ontology (GO) - Molecular Function for MIR492 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23802567
genes like me logo Genes that share ontologies with MIR492: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR492 Gene

Localization for MIR492 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR492 Gene

Pathways & Interactions for MIR492 Gene

SuperPathways for MIR492 Gene

No Data Available

Interacting Proteins for MIR492 Gene

Gene Ontology (GO) - Biological Process for MIR492 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IDA 23802567
GO:0016525 negative regulation of angiogenesis IDA 23802567
GO:0035195 gene silencing by miRNA IDA 23802567
GO:0043537 negative regulation of blood vessel endothelial cell migration IDA 23802567
GO:1905563 negative regulation of vascular endothelial cell proliferation IDA 23802567
genes like me logo Genes that share ontologies with MIR492: view

No data available for Pathways by source and SIGNOR curated interactions for MIR492 Gene

Drugs & Compounds for MIR492 Gene

No Compound Related Data Available

Transcripts for MIR492 Gene

mRNA/cDNA for MIR492 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR492 Gene

No ASD Table

Relevant External Links for MIR492 Gene

GeneLoc Exon Structure for
MIR492
ECgene alternative splicing isoforms for
MIR492

Expression for MIR492 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR492 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR492 Gene:

MIR492
genes like me logo Genes that share expression patterns with MIR492: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR492 Gene

Orthologs for MIR492 Gene

Evolution for MIR492 Gene

ENSEMBL:
Gene Tree for MIR492 (if available)
TreeFam:
Gene Tree for MIR492 (if available)

No data available for Orthologs for MIR492 Gene

Paralogs for MIR492 Gene

No data available for Paralogs for MIR492 Gene

Variants for MIR492 Gene

Sequence variations from dbSNP and Humsavar for MIR492 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1003230487 -- 94,834,891(+) T/C downstream_transcript_variant
rs1003235098 -- 94,833,667(+) A/T upstream_transcript_variant
rs1003692152 -- 94,834,665(+) A/G downstream_transcript_variant
rs1004751910 -- 94,834,919(+) G/A downstream_transcript_variant
rs1005632063 -- 94,833,982(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR492 Gene

Variant ID Type Subtype PubMed ID
nsv1044757 CNV gain 25217958
nsv53265 CNV deletion 16902084
nsv7234 OTHER inversion 18451855

Additional Variant Information for MIR492 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR492

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR492 Gene

Disorders for MIR492 Gene

Additional Disease Information for MIR492

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR492 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR492 Gene

Publications for MIR492 Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 44 58
  2. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 44 58
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y … Wu X (Cancer prevention research (Philadelphia, Pa.) 2008) 3 44 58
  4. MicroRNA-492 overexpression involves in cell proliferation, migration, and radiotherapy response of cervical squamous cell carcinomas. (PMID: 28802022) Liu M … Wu L (Molecular carcinogenesis 2018) 3 58
  5. miR-492G>C polymorphism (rs2289030) is associated with overall survival of hepatocellular carcinoma patients. (PMID: 26753964) Yu G … Jiang DK (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 58

Products for MIR492 Gene

Sources for MIR492 Gene

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