Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR492 Gene

Subcategory (RNA class) for MIR492 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR492 Gene

  • MicroRNA 492 2 3 5
  • Hsa-Mir-492 3
  • MIRN492 3

External Ids for MIR492 Gene

ORGUL Members for MIR492 Gene

Previous HGNC Symbols for MIR492 Gene

  • MIRN492

Previous GeneCards Identifiers for MIR492 Gene

  • GC12P093753
  • GC12P095229
  • GC12P095230
  • GC12P095232
  • GC12P095234
  • GC12P095236

Summaries for MIR492 Gene

Entrez Gene Summary for MIR492 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR492 Gene

MIR492 (MicroRNA 492) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR492 Gene

Genomics for MIR492 Gene

Genomic Location for MIR492 Gene

Chromosome:
12
Start:
94,834,398 bp from pter
End:
94,834,513 bp from pter
Size:
116 bases
Orientation:
Plus strand

Genomic View for MIR492 Gene

Genes around MIR492 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR492 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR492 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR492 Gene

No data available for Regulatory Elements for MIR492 Gene

Proteins for MIR492 Gene

Post-translational modifications for MIR492 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR492 Gene

Domains & Families for MIR492 Gene

Gene Families for MIR492 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR492: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR492 Gene

Function for MIR492 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR492 Gene

Localization for MIR492 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR492 Gene

Pathways & Interactions for MIR492 Gene

SuperPathways for MIR492 Gene

No Data Available

Interacting Proteins for MIR492 Gene

Gene Ontology (GO) - Biological Process for MIR492 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR492 Gene

Drugs & Compounds for MIR492 Gene

No Compound Related Data Available

Transcripts for MIR492 Gene

mRNA/cDNA for MIR492 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR492 Gene

No ASD Table

Relevant External Links for MIR492 Gene

GeneLoc Exon Structure for
MIR492
ECgene alternative splicing isoforms for
MIR492

Expression for MIR492 Gene

mRNA expression in normal human tissues for MIR492 Gene

genes like me logo Genes that share expression patterns with MIR492: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR492 Gene

Orthologs for MIR492 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR492 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-492 36
  • 97 (a)
OneToOne
Species with no ortholog for MIR492:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR492 Gene

ENSEMBL:
Gene Tree for MIR492 (if available)
TreeFam:
Gene Tree for MIR492 (if available)

Paralogs for MIR492 Gene

No data available for Paralogs for MIR492 Gene

Variants for MIR492 Gene

Sequence variations from dbSNP and Humsavar for MIR492 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs539208373 -- 94,832,398(+) GAGTG(C/T)ATGGT upstream-variant-2KB
rs573152891 -- 94,832,435(+) CTTCA(A/G)AAAAT upstream-variant-2KB
rs557522776 -- 94,832,425(+) CATAA(C/T)TTAAC upstream-variant-2KB
rs7962769 -- 94,832,452(+) ACATG(G/T)CTAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR492 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
nsv899446 CNV Gain 21882294
nsv53265 CNV Loss 16902084

Relevant External Links for MIR492 Gene

HapMap Linkage Disequilibrium report
MIR492

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR492 Gene

Disorders for MIR492 Gene

Relevant External Links for MIR492

Genetic Association Database (GAD)
MIR492
Human Genome Epidemiology (HuGE) Navigator
MIR492
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR492

No disorders were found for MIR492 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR492 Gene

Publications for MIR492 Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J. … Wu X. (Mol. Carcinog. 2010) 3 48 67
  2. Myeloid zinc-finger 1 (MZF-1) suppresses prostate tumor growth through enforcing ferroportin-conducted iron egress. (PMID: 25284586) Chen Y. … Liu S. (Oncogene 2015) 3
  3. Upregulation of microRNAa89492 induced by epigenetic drug treatment inhibits the malignant phenotype of clear cell renal cell carcinoma inA vitro. (PMID: 25815441) Wu A. … Yang Z. (Mol Med Rep 2015) 3
  4. MiR-492 contributes to cell proliferation and cell cycle of human breast cancer cells by suppressing SOX7 expression. (PMID: 25407488) Shen F. … Xu B. (Tumour Biol. 2014) 3
  5. MiR-492 impairs the angiogenic potential of endothelial cells. (PMID: 23802567) Patella F. … Rainaldi G. (J. Cell. Mol. Med. 2013) 3

Products for MIR492 Gene

Sources for MIR492 Gene

Back to Top

Content