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Aliases for MIR492 Gene

Subcategory (RNA class) for MIR492 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR492 Gene

  • MicroRNA 492 2 3
  • Hsa-Mir-492 3
  • MIRN492 3

External Ids for MIR492 Gene

ORGUL Members for MIR492 Gene

Previous HGNC Symbols for MIR492 Gene

  • MIRN492

Previous GeneCards Identifiers for MIR492 Gene

  • GC12P093753
  • GC12P095229
  • GC12P095230
  • GC12P095232
  • GC12P095234
  • GC12P095236

Summaries for MIR492 Gene

Entrez Gene Summary for MIR492 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR492 Gene

MIR492 (MicroRNA 492) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR492 include esophageal cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR492 Gene

Genomics for MIR492 Gene

Genomic Location for MIR492 Gene

Start:
94,834,398 bp from pter
End:
94,834,513 bp from pter
Size:
116 bases
Orientation:
Plus strand

Genomic View for MIR492 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR492 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR492 Gene

No data available for Regulatory Elements for MIR492 Gene

Proteins for MIR492 Gene

Post-translational modifications for MIR492 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR492 Gene

Domains for MIR492 Gene

Gene Families for MIR492 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR492: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR492 Gene

Function for MIR492 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR492 Gene

Localization for MIR492 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR492 Gene

Pathways for MIR492 Gene

SuperPathways for MIR492 Gene

No Data Available

Interacting Proteins for MIR492 Gene

Gene Ontology (GO) - Biological Process for MIR492 Gene

None

No data available for Pathways by source for MIR492 Gene

Transcripts for MIR492 Gene

mRNA/cDNA for MIR492 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR492 Gene

No ASD Table

Relevant External Links for MIR492 Gene

GeneLoc Exon Structure for
MIR492
ECgene alternative splicing isoforms for
MIR492

Expression for MIR492 Gene

mRNA expression in normal human tissues for MIR492 Gene

genes like me logo Genes that share expressions with MIR492: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR492 Gene

Orthologs for MIR492 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR492 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-492 36
  • 97 (a)
OneToOne
Species with no ortholog for MIR492:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR492 Gene

ENSEMBL:
Gene Tree for MIR492 (if available)
TreeFam:
Gene Tree for MIR492 (if available)

Paralogs for MIR492 Gene

No data available for Paralogs for MIR492 Gene

Variants for MIR492 Gene

Sequence variations from dbSNP and Humsavar for MIR492 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7962769 -- 94,832,452(+) ACATG(G/T)CTAGG upstream-variant-2KB
rs539208373 -- 94,832,398(+) GAGTG(C/T)ATGGT upstream-variant-2KB
rs557522776 -- 94,832,425(+) CATAA(C/T)TTAAC upstream-variant-2KB
rs573152891 -- 94,832,435(+) CTTCA(A/G)AAAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR492 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
nsv899446 CNV Gain 21882294
nsv53265 CNV Loss 16902084

Relevant External Links for MIR492 Gene

HapMap Linkage Disequilibrium report
MIR492

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR492 Gene

Disorders for MIR492 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MIR492 Gene including...

Search for MIR492 Gene in MalaCards »

Relevant External Links for MIR492

Genetic Association Database (GAD)
MIR492
Human Genome Epidemiology (HuGE) Navigator
MIR492
genes like me logo Genes that share disorders with MIR492: view

No data available for UniProtKB/Swiss-Prot for MIR492 Gene

Publications for MIR492 Gene

  1. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y. … Wu X. (Cancer Prev Res (Phila) 2008) 3 48
  2. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J. … Wu X. (Mol. Carcinog. 2010) 3 48
  3. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J. … Wu X. (Carcinogenesis 2010) 3 48
  4. MicroRNA-492 is processed from the keratin 19 gene and up-regulated in metastatic hepatoblastoma. (PMID: 21319197) von Frowein J. … Schmid I. (Hepatology 2011) 3
  5. A miRNA-492 binding-site polymorphism in BSG (basigin) confers risk to psoriasis in central south Chinese population. (PMID: 21655935) Wu L.S. … Chen X. (Hum. Genet. 2011) 3

Products for MIR492 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR492
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR492
    • Block miRNA regulation of MIR492 using miScript Target Protectors

    Sources for MIR492 Gene

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