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Aliases for MIR491 Gene

Subcategory (RNA class) for MIR491 Gene


Quality Score for this RNA gene is


Aliases for MIR491 Gene

  • MicroRNA 491 2 3 5
  • Hsa-Mir-491 3
  • Mir-491 3
  • MIRN491 3

External Ids for MIR491 Gene

ORGUL Members for MIR491 Gene

Previous HGNC Symbols for MIR491 Gene

  • MIRN491

Summaries for MIR491 Gene

Entrez Gene Summary for MIR491 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR491 Gene

MIR491 (MicroRNA 491) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR491 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR491 Gene

Genomics for MIR491 Gene

GeneHancer (GH) Regulatory Elements for MIR491 Gene

Promoters and enhancers for MIR491 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I020682 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.5 -31.5 -31493 3.4 PKNOX1 ATF1 FOXA2 ARID4B SIN3A BRCA1 ZNF48 YY1 ZNF121 GLIS2 FOCAD FOCAD-AS1 MIR491
GH09I020640 Enhancer 1.1 Ensembl ENCODE 10.1 -75.5 -75473 1.2 HDGF PKNOX1 SMAD1 RB1 NFIB BMI1 YBX1 BATF KLF5 IRF4 MIR491 FOCAD MLLT3
GH09I020557 Enhancer 0.9 Ensembl ENCODE 9.9 -157.4 -157358 1.7 ZFP64 EBF1 ZIC2 ZNF213 POLR2A PRDM10 FOSL2 ZNF600 FOS ZBTB20 MLLT3 FOCAD MIR491 RPL7AP48
GH09I020872 Enhancer 0.7 Ensembl ENCODE 10.1 +156.9 156913 1.2 SP1 GLIS1 FOS RUNX3 SPI1 FOCAD MIR491 HACD4 SNORA30B LOC105375989
GH09I020678 Enhancer 0.6 ENCODE 11.1 -37.1 -37129 1 PKNOX1 MAX CEBPB ZNF398 SP1 JUND TARDBP FOSL2 FOS NR2F6 FOCAD MIR491 FOCAD-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR491 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR491 Gene

Genomic Locations for MIR491 Gene
84 bases
Plus strand

Genomic View for MIR491 Gene

Genes around MIR491 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR491 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR491 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR491 Gene

Proteins for MIR491 Gene

Post-translational modifications for MIR491 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR491 Gene

Domains & Families for MIR491 Gene

Gene Families for MIR491 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR491: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR491 Gene

Function for MIR491 Gene

Phenotypes From GWAS Catalog for MIR491 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR491 Gene

Localization for MIR491 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR491 Gene

Pathways & Interactions for MIR491 Gene

SuperPathways for MIR491 Gene

No Data Available

Interacting Proteins for MIR491 Gene

Gene Ontology (GO) - Biological Process for MIR491 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR491 Gene

Drugs & Compounds for MIR491 Gene

No Compound Related Data Available

Transcripts for MIR491 Gene

mRNA/cDNA for MIR491 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR491 Gene

No ASD Table

Relevant External Links for MIR491 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR491 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR491 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR491 Gene:

genes like me logo Genes that share expression patterns with MIR491: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR491 Gene

Orthologs for MIR491 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR491 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-491 34
  • 100 (a)
(Bos Taurus)
Mammalia bta-mir-491 34
  • 99 (a)
(Canis familiaris)
Mammalia cfa-mir-491 34
  • 99 (a)
(Mus musculus)
Mammalia Mir491 34
  • 93 (a)
Species where no ortholog for MIR491 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR491 Gene

Gene Tree for MIR491 (if available)
Gene Tree for MIR491 (if available)

Paralogs for MIR491 Gene

No data available for Paralogs for MIR491 Gene

Variants for MIR491 Gene

Sequence variations from dbSNP and Humsavar for MIR491 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1001370465 -- 20,715,272(+) A/G upstream_transcript_variant
rs1001826197 -- 20,715,590(+) A/T upstream_transcript_variant
rs1002531821 -- 20,715,043(+) TTTTTTT/TTTTTT upstream_transcript_variant
rs1002781408 -- 20,716,520(+) G/T downstream_transcript_variant
rs1003451700 -- 20,714,140(+) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR491 Gene

Variant ID Type Subtype PubMed ID
esv2764150 CNV gain+loss 21179565
nsv1028928 CNV loss 25217958
nsv613747 CNV loss 21841781

Additional Variant Information for MIR491 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR491 Gene

Disorders for MIR491 Gene

Additional Disease Information for MIR491

No disorders were found for MIR491 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR491 Gene

Publications for MIR491 Gene

  1. The miR-491-3p/Sp3/ABCB1 axis attenuates multidrug resistance of hepatocellular carcinoma. (PMID: 28844709) Zhao Y … Ren J (Cancer letters 2017) 3 58
  2. miR-491-5p, mediated by Foxi1, functions as a tumor suppressor by targeting Wnt3a/β-catenin signaling in the development of gastric cancer. (PMID: 28358374) Sun R … Huang C (Cell death & disease 2017) 3 58
  3. Up-regulation of microRNA-491-5p suppresses cell proliferation and promotes apoptosis by targeting FOXP4 in human osteosarcoma. (PMID: 27704627) Yin Z … Li M (Cell proliferation 2017) 3 58
  4. MiR-491 attenuates cancer stem cells-like properties of hepatocellular carcinoma by inhibition of GIT-1/NF-κB-mediated EMT. (PMID: 26188902) Yang X … Yang L (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 58
  5. miR-491-5p suppresses cell growth and invasion by targeting Notch3 in nasopharyngeal carcinoma. (PMID: 27035429) Zhang Q … Xu LG (Oncology reports 2016) 3 58

Products for MIR491 Gene

Sources for MIR491 Gene

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