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Aliases for MIR491 Gene

Subcategory (RNA class) for MIR491 Gene


Quality Score for this RNA gene is


Aliases for MIR491 Gene

  • MicroRNA 491 2 3 5
  • Hsa-Mir-491 3
  • Mir-491 3
  • MIRN491 3

External Ids for MIR491 Gene

ORGUL Members for MIR491 Gene

Previous HGNC Symbols for MIR491 Gene

  • MIRN491

Summaries for MIR491 Gene

Entrez Gene Summary for MIR491 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR491 Gene

MIR491 (MicroRNA 491) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR491 Gene

Genomics for MIR491 Gene

Regulatory Elements for MIR491 Gene

Enhancers for MIR491 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F020682 1.1 ENCODE 11.5 -31.5 -31493 3.4 ATF1 PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 BRCA1 ZNF48 YY1 ZNF121 FOCAD MIR491 FOCAD-AS1
GH09F020640 1.2 Ensembl ENCODE 10.1 -75.5 -75474 1.2 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 SIN3A BMI1 YBX1 ZBTB40 YY1 MIR491 MLLT3 FOCAD
GH09F020692 0.9 Ensembl 12.1 -23.2 -23204 1.0 ELF3 ATF1 MLX ARID4B FEZF1 DMAP1 THRB RARA ZNF766 GATA4 MIR491 FOCAD FOCAD-AS1 GC09P020716
GH09F020678 0.9 Ensembl ENCODE 11.1 -37.1 -37094 1.1 GTF2F1 PKNOX1 ESRRA CEBPB MAX JUND TARDBP NR2F6 FOS TCF7L2 FOCAD MIR491 FOCAD-AS1
GH09F020557 1 Ensembl ENCODE 9.9 -157.3 -157254 1.9 ZFP64 EBF1 ZIC2 ZNF600 FOS PRDM10 MAFK ZBTB20 USF2 ZEB2 MLLT3 FOCAD MIR491 RPL7AP48
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR491 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR491 Gene

20,716,105 bp from pter
20,716,188 bp from pter
84 bases
Plus strand

Genomic View for MIR491 Gene

Genes around MIR491 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR491 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR491 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR491 Gene

Proteins for MIR491 Gene

Post-translational modifications for MIR491 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR491 Gene

Domains & Families for MIR491 Gene

Gene Families for MIR491 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR491: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR491 Gene

Function for MIR491 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR491 Gene

Localization for MIR491 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR491 Gene

Pathways & Interactions for MIR491 Gene

SuperPathways for MIR491 Gene

No Data Available

Interacting Proteins for MIR491 Gene

Gene Ontology (GO) - Biological Process for MIR491 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR491 Gene

Transcripts for MIR491 Gene

mRNA/cDNA for MIR491 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR491 Gene

No ASD Table

Relevant External Links for MIR491 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR491 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR491 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR491 Gene:

genes like me logo Genes that share expression patterns with MIR491: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR491 Gene

Orthologs for MIR491 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR491 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-491 35
  • 100 (a)
(Bos Taurus)
Mammalia bta-mir-491 35
  • 99 (a)
(Canis familiaris)
Mammalia cfa-mir-491 35
  • 99 (a)
(Mus musculus)
Mammalia Mir491 35
  • 93 (a)
Species where no ortholog for MIR491 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR491 Gene

Gene Tree for MIR491 (if available)
Gene Tree for MIR491 (if available)

Paralogs for MIR491 Gene

No data available for Paralogs for MIR491 Gene

Variants for MIR491 Gene

Sequence variations from dbSNP and Humsavar for MIR491 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs112148663 -- 20,715,937(+) GTAGC(C/G)TTTAG intron-variant, upstream-variant-2KB
rs112304664 -- 20,714,677(+) CTTCC(C/T)TCCTT intron-variant, upstream-variant-2KB
rs112915556 -- 20,716,070(+) TACTT(C/T)CAACA intron-variant, upstream-variant-2KB
rs115523831 -- 20,716,373(+) GTAGG(A/G)TGGCT intron-variant, downstream-variant-500B
rs116498836 -- 20,714,962(+) TGACC(A/G)TTTGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR491 Gene

Variant ID Type Subtype PubMed ID
nsv613747 CNV loss 21841781
nsv1028928 CNV loss 25217958
esv2764150 CNV gain+loss 21179565

Relevant External Links for MIR491 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR491 Gene

Disorders for MIR491 Gene

Relevant External Links for MIR491

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR491 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR491 Gene

Publications for MIR491 Gene

  1. [miR-491 inhibits the proliferation, invasion and migration of hepatocellular carcinoma cell via down-regulating TPX2 expression]. (PMID: 27053618) Wang J. … Yang W. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2016) 3 64
  2. MicroRNA-491-5p suppresses cervical cancer cell growth by targeting hTERT. (PMID: 26034994) Zhao Q. … Li X.B. (Oncol. Rep. 2015) 3 64
  3. Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma. (PMID: 24747968) Li X. … Zhang W. (Oncogene 2015) 3 64
  4. miR-491-5p functions as a tumor suppressor by targeting JMJD2B in ERI+-positive breast cancer. (PMID: 25725194) Hui Z. … Hui L. (FEBS Lett. 2015) 3 64
  5. Low Expression of miR-491 Promotes Esophageal Cancer Cell Invasion by Targeting TPX2. (PMID: 26279431) Niu H. … Zhu Y. (Cell. Physiol. Biochem. 2015) 3 64

Products for MIR491 Gene

Sources for MIR491 Gene

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