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Aliases for MIR491 Gene

Subcategory (RNA class) for MIR491 Gene


Quality Score for this RNA gene is


Aliases for MIR491 Gene

  • MicroRNA 491 2 3
  • Hsa-Mir-491 3
  • Mir-491 3
  • MIRN491 3

External Ids for MIR491 Gene

ORGUL Members for MIR491 Gene

Previous HGNC Symbols for MIR491 Gene

  • MIRN491

Summaries for MIR491 Gene

Entrez Gene Summary for MIR491 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR491 Gene

MIR491 (MicroRNA 491) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR491 Gene

Genomics for MIR491 Gene

Genomic Location for MIR491 Gene

20,716,100 bp from pter
20,716,209 bp from pter
110 bases
Plus strand

Genomic View for MIR491 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR491 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR491 Gene

No data available for Regulatory Elements for MIR491 Gene

Proteins for MIR491 Gene

Post-translational modifications for MIR491 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR491 Gene

Domains & Families for MIR491 Gene

Gene Families for MIR491 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR491: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR491 Gene

Function for MIR491 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR491 Gene

Localization for MIR491 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR491 Gene

Pathways & Interactions for MIR491 Gene

SuperPathways for MIR491 Gene

No Data Available

Interacting Proteins for MIR491 Gene

Gene Ontology (GO) - Biological Process for MIR491 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR491 Gene

Drugs & Compounds for MIR491 Gene

No Compound Related Data Available

Transcripts for MIR491 Gene

mRNA/cDNA for MIR491 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR491 Gene

No ASD Table

Relevant External Links for MIR491 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR491 Gene

mRNA expression in normal human tissues for MIR491 Gene

genes like me logo Genes that share expression patterns with MIR491: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR491 Gene

Orthologs for MIR491 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR491 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-491 36
  • 99 (a)
(Canis familiaris)
Mammalia cfa-mir-491 36
  • 99 (a)
(Mus musculus)
Mammalia Mir491 36
  • 93 (a)
(Pan troglodytes)
Mammalia ptr-mir-491 36
  • 100 (a)
Species with no ortholog for MIR491:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR491 Gene

Gene Tree for MIR491 (if available)
Gene Tree for MIR491 (if available)

Paralogs for MIR491 Gene

No data available for Paralogs for MIR491 Gene

Variants for MIR491 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR491 Gene

Variant ID Type Subtype PubMed ID
dgv8119n71 CNV Gain 21882294
nsv892723 CNV Loss 21882294
nsv892724 CNV Gain 21882294

Relevant External Links for MIR491 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR491 Gene

Disorders for MIR491 Gene

Relevant External Links for MIR491

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR491: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR491 Gene

Publications for MIR491 Gene

  1. miR-491-5p functions as a tumor suppressor by targeting JMJD2B in ERI+-positive breast cancer. (PMID: 25725194) Hui Z. … Hui L. (FEBS Lett. 2015) 67
  2. Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma. (PMID: 24747968) Li X. … Zhang W. (Oncogene 2015) 67
  3. Inhibition of TGF-I^/SMAD3/NF-I_B signaling by microRNA-491 is involved in arsenic trioxide-induced anti-angiogenesis in hepatocellular carcinoma cells. (PMID: 25196641) Jiang F. … Zhang J. (Toxicol. Lett. 2014) 67
  4. Arsenic trioxide attenuates the invasion potential of human liver cancer cells through the demethylation-activated microRNA-491. (PMID: 24680928) Wang X. … Li Y. (Toxicol. Lett. 2014) 67
  5. miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL and EGFR leading to BIM activation. (PMID: 25299770) Denoyelle C. … Poulain L. (Cell Death Dis 2014) 67

Products for MIR491 Gene

Sources for MIR491 Gene

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