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Aliases for MIR490 Gene

Subcategory (RNA class) for MIR490 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR490 Gene

  • MicroRNA 490 2 3 5
  • Hsa-Mir-490 3
  • MiR-490 3
  • MIRN490 3

External Ids for MIR490 Gene

ORGUL Members for MIR490 Gene

Previous HGNC Symbols for MIR490 Gene

  • MIRN490

Previous GeneCards Identifiers for MIR490 Gene

  • GC07P136239
  • GC07P136587

Summaries for MIR490 Gene

Entrez Gene Summary for MIR490 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR490 Gene

MIR490 (MicroRNA 490) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR490 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR490 Gene

Genomics for MIR490 Gene

Regulatory Elements for MIR490 Gene

Enhancers for MIR490 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H136953 0.8 Ensembl ENCODE 10.9 +52.2 52233 4 ZNF146 FOXA2 JUN FOS FOXA1 CHRM2 MIR490 KRT8P51 GC07M137079
GH07H136924 0.4 ENCODE 11.8 +22.2 22180 1 STAT1 JUN CHRM2 MIR490 KRT8P51
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR490 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR490 Gene

Chromosome:
7
Start:
136,903,167 bp from pter
End:
136,903,294 bp from pter
Size:
128 bases
Orientation:
Plus strand

Genomic View for MIR490 Gene

Genes around MIR490 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR490 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR490 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR490 Gene

Proteins for MIR490 Gene

Post-translational modifications for MIR490 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR490 Gene

Domains & Families for MIR490 Gene

Gene Families for MIR490 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR490: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR490 Gene

Function for MIR490 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR490
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR490 Gene

Localization for MIR490 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR490 Gene

Pathways & Interactions for MIR490 Gene

SuperPathways for MIR490 Gene

No Data Available

Interacting Proteins for MIR490 Gene

Gene Ontology (GO) - Biological Process for MIR490 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR490 Gene

Drugs & Compounds for MIR490 Gene

No Compound Related Data Available

Transcripts for MIR490 Gene

mRNA/cDNA for MIR490 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR490
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR490 Gene

No ASD Table

Relevant External Links for MIR490 Gene

GeneLoc Exon Structure for
MIR490
ECgene alternative splicing isoforms for
MIR490

Expression for MIR490 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR490 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR490 Gene:

MIR490
genes like me logo Genes that share expression patterns with MIR490: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR490 Gene

Orthologs for MIR490 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR490 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-490 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-490 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-490 34
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir490 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-490 34
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-490 34
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-490 34
  • 86 (a)
OneToOne
Species where no ortholog for MIR490 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR490 Gene

ENSEMBL:
Gene Tree for MIR490 (if available)
TreeFam:
Gene Tree for MIR490 (if available)

Paralogs for MIR490 Gene

No data available for Paralogs for MIR490 Gene

Variants for MIR490 Gene

Sequence variations from dbSNP and Humsavar for MIR490 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000882698 -- 136,901,648(+) GAGAA(C/T)ATACA intron-variant, upstream-variant-2KB
rs1004092155 -- 136,902,058(+) TTGTT(C/T)ATAAC intron-variant, upstream-variant-2KB
rs1004320038 -- 136,902,587(+) AAACT(A/G)TAGTG intron-variant, upstream-variant-2KB
rs1006243651 -- 136,901,449(+) GTATT(C/T)ATTCA intron-variant, upstream-variant-2KB
rs1009656723 -- 136,903,439(+) GGATA(C/T)TGTTA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR490 Gene

Variant ID Type Subtype PubMed ID
esv2735202 CNV deletion 23290073
nsv831147 CNV gain 17160897

Relevant External Links for MIR490 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR490

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR490 Gene

Disorders for MIR490 Gene

Relevant External Links for MIR490

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR490

No disorders were found for MIR490 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR490 Gene

Publications for MIR490 Gene

  1. Long non-coding RNA colon cancer-associated transcript 1 functions as a competing endogenous RNA to regulate cyclin-dependent kinase 1 expression by sponging miR-490-3p in hepatocellular carcinoma progression. (PMID: 28381168) Dou C … Li T (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  2. Epigenetic silencing of miR-490-3p promotes development of an aggressive colorectal cancer phenotype through activation of the Wnt/β-catenin signaling pathway. (PMID: 27037061) Zheng K … Zhao L (Cancer letters 2016) 3 60
  3. The correlation between microRNA490-3p and TGFα in endometrial carcinoma tumorigenesis and progression. (PMID: 26843615) Sun KX … Zhao Y (Oncotarget 2016) 3 60
  4. The long noncoding RNA colon cancer-associated transcript-1/miR-490 axis regulates gastric cancer cell migration by targeting hnRNPA1. (PMID: 26825578) Zhou B … Qiao H (IUBMB life 2016) 3 60
  5. miR-490-5p suppresses tumour growth in renal cell carcinoma through targeting PIK3CA. (PMID: 26559013) Chen K … Ye Z (Biology of the cell 2016) 3 60

Products for MIR490 Gene

Sources for MIR490 Gene

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