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Aliases for MIR490 Gene

Subcategory (RNA class) for MIR490 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR490 Gene

  • MicroRNA 490 2 3
  • Hsa-Mir-490 3
  • MiR-490 3
  • MIRN490 3

External Ids for MIR490 Gene

ORGUL Members for MIR490 Gene

Previous HGNC Symbols for MIR490 Gene

  • MIRN490

Previous GeneCards Identifiers for MIR490 Gene

  • GC07P136239
  • GC07P136587

Summaries for MIR490 Gene

Entrez Gene Summary for MIR490 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR490 Gene

MIR490 (MicroRNA 490) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR490 Gene

Genomics for MIR490 Gene

Genomic Location for MIR490 Gene

Start:
136,903,167 bp from pter
End:
136,903,294 bp from pter
Size:
128 bases
Orientation:
Plus strand

Genomic View for MIR490 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR490 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR490 Gene

No data available for Regulatory Elements for MIR490 Gene

Proteins for MIR490 Gene

Post-translational modifications for MIR490 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR490 Gene

Domains for MIR490 Gene

Gene Families for MIR490 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR490: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR490 Gene

Function for MIR490 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR490 Gene

Localization for MIR490 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR490 Gene

Pathways for MIR490 Gene

SuperPathways for MIR490 Gene

No Data Available

Interacting Proteins for MIR490 Gene

Gene Ontology (GO) - Biological Process for MIR490 Gene

None

No data available for Pathways by source for MIR490 Gene

Transcripts for MIR490 Gene

mRNA/cDNA for MIR490 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR490 Gene

No ASD Table

Relevant External Links for MIR490 Gene

GeneLoc Exon Structure for
MIR490
ECgene alternative splicing isoforms for
MIR490

Expression for MIR490 Gene

mRNA expression in normal human tissues for MIR490 Gene

genes like me logo Genes that share expressions with MIR490: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR490 Gene

Orthologs for MIR490 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR490 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-490 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-490 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-490 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir490 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-490 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-490 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-490 36
  • 86 (a)
OneToOne
Species with no ortholog for MIR490:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR490 Gene

ENSEMBL:
Gene Tree for MIR490 (if available)
TreeFam:
Gene Tree for MIR490 (if available)

Paralogs for MIR490 Gene

No data available for Paralogs for MIR490 Gene

Variants for MIR490 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR490 Gene

Variant ID Type Subtype PubMed ID
nsv889235 CNV Loss 21882294
esv2735202 CNV Deletion 23290073
nsv831147 CNV Gain 17160897

Relevant External Links for MIR490 Gene

HapMap Linkage Disequilibrium report
MIR490

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR490 Gene

Disorders for MIR490 Gene

No disorders were found for MIR490 Gene.

No data available for UniProtKB/Swiss-Prot for MIR490 Gene

Publications for MIR490 Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. New miRNAs cloned from neuroblastoma. (PMID: 18230126) Afanasyeva E.A. … Westermann F. (BMC Genomics 2008) 3
  5. Characterization of the uterine leiomyoma microRNAome by deep sequencing. (PMID: 22446413) Georgieva B. … Baev V. (Genomics 2012) 3

Products for MIR490 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR490
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR490
    • Block miRNA regulation of MIR490 using miScript Target Protectors

    Sources for MIR490 Gene

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