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Aliases for MIR489 Gene

Subcategory (RNA class) for MIR489 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR489 Gene

  • MicroRNA 489 2 3
  • Hsa-Mir-489 3
  • MIRN489 3

External Ids for MIR489 Gene

Previous Symbols for MIR489 Gene

  • MIRN489

Summaries for MIR489 Gene

Entrez Gene Summary for MIR489 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR489 Gene

MIR489 (MicroRNA 489) is a RNA Gene, and belongs to miRNA RNA class.

fRNAdb sequence ontologies for MIR489 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR489

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR489 Gene

Genomics for MIR489 Gene

Genomic Location for MIR489 Gene

Start:
93,483,936 bp from pter
End:
93,484,019 bp from pter
Size:
84 bases
Orientation:
Minus strand

Genomic View for MIR489 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR489 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR489 Gene

ORGUL Member Location for MIR489 Gene

ORGUL Member Location for MIR489 gene

No data available for Regulatory Elements for MIR489 Gene

Proteins for MIR489 Gene

Post-translational modifications for MIR489 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR489 Gene

Domains for MIR489 Gene

Gene Families for MIR489 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR489: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR489 Gene

Function for MIR489 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR489 Gene

Localization for MIR489 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR489 Gene

Pathways for MIR489 Gene

SuperPathways for MIR489 Gene

No Data Available

Interacting Proteins for MIR489 Gene

Gene Ontology (GO) - Biological Process for MIR489 Gene

None

No data available for Pathways by source for MIR489 Gene

Transcripts for MIR489 Gene

fRNAdb Secondary structures for MIR489 Gene

  • hsa-mir-489_MI0003124_Homo_sapiens_miR-489_stem-loop_hairpin

mRNA/cDNA for MIR489 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR489 Gene

No ASD Table

Relevant External Links for MIR489 Gene

GeneLoc Exon Structure for
MIR489
ECgene alternative splicing isoforms for
MIR489

Expression for MIR489 Gene

mRNA expression in normal human tissues for MIR489 Gene

genes like me logo Genes that share expressions with MIR489: view

Orthologs for MIR489 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR489 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-489 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-489 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-489 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir489 37
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-489 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-489 37
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-489 37
  • 69 (a)
OneToOne
Species with no ortholog for MIR489:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR489 Gene

ENSEMBL:
Gene Tree for MIR489 (if available)
TreeFam:
Gene Tree for MIR489 (if available)

Paralogs for MIR489 Gene

No data available for Paralogs for MIR489 Gene

Variants for MIR489 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR489 Gene

Variant ID Type Subtype PubMed ID
nsv888737 CNV Loss 21882294

Relevant External Links for MIR489 Gene

HapMap Linkage Disequilibrium report
MIR489

No data available for Sequence variations from dbSNP and Humsavar for MIR489 Gene

Disorders for MIR489 Gene

No disorders were found for MIR489 Gene.

No data available for UniProtKB/Swiss-Prot for MIR489 Gene

Publications for MIR489 Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. miR-489 is a tumour-suppressive miRNA target PTPN11 in hypopharyngeal squamous cell carcinoma (HSCC). (PMID: 20700123) Kikkawa N. … Seki N. (Br. J. Cancer 2010) 3
  5. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J. … Kaessmann H. (Genome Res. 2013) 3

Products for MIR489 Gene

Sources for MIR489 Gene

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