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Aliases for MIR489 Gene

Subcategory (RNA class) for MIR489 Gene


Quality Score for this RNA gene is


Aliases for MIR489 Gene

  • MicroRNA 489 2 3 5
  • Hsa-Mir-489 3
  • Mir-489 3
  • MIRN489 3

External Ids for MIR489 Gene

Previous HGNC Symbols for MIR489 Gene

  • MIRN489

Previous GeneCards Identifiers for MIR489 Gene

  • GC07M092953
  • GC07M093114
  • GC07M093116
  • GC07M093118

Summaries for MIR489 Gene

Entrez Gene Summary for MIR489 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR489 Gene

MIR489 (MicroRNA 489) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR489 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR489

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR489 Gene

Genomics for MIR489 Gene

Genomic Location for MIR489 Gene

93,483,936 bp from pter
93,484,019 bp from pter
84 bases
Minus strand

Genomic View for MIR489 Gene

Genes around MIR489 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR489 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR489 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR489 Gene

ORGUL Member Location for MIR489 Gene

ORGUL Member Location for MIR489 gene

No data available for Regulatory Elements for MIR489 Gene

Proteins for MIR489 Gene

Post-translational modifications for MIR489 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR489 Gene

Domains & Families for MIR489 Gene

Gene Families for MIR489 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR489: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR489 Gene

Function for MIR489 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR489 Gene

Localization for MIR489 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR489 Gene

Pathways & Interactions for MIR489 Gene

SuperPathways for MIR489 Gene

No Data Available

Interacting Proteins for MIR489 Gene

Gene Ontology (GO) - Biological Process for MIR489 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR489 Gene

Drugs & Compounds for MIR489 Gene

No Compound Related Data Available

Transcripts for MIR489 Gene

fRNAdb Secondary structures for MIR489 Gene

  • hsa-mir-489_MI0003124_Homo_sapiens_miR-489_stem-loop_hairpin

mRNA/cDNA for MIR489 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR489 Gene

No ASD Table

Relevant External Links for MIR489 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR489 Gene

mRNA expression in normal human tissues for MIR489 Gene

genes like me logo Genes that share expression patterns with MIR489: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR489 Gene

Orthologs for MIR489 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR489 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-489 36
  • 89 (a)
(Canis familiaris)
Mammalia cfa-mir-489 36
  • 96 (a)
(Mus musculus)
Mammalia Mir489 36
  • 63 (a)
(Pan troglodytes)
Mammalia ptr-mir-489 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-489 36
  • 76 (a)
(Anolis carolinensis)
Reptilia aca-mir-489 36
  • 77 (a)
(Danio rerio)
Actinopterygii dre-mir-489 36
  • 69 (a)
Species with no ortholog for MIR489:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR489 Gene

Gene Tree for MIR489 (if available)
Gene Tree for MIR489 (if available)

Paralogs for MIR489 Gene

No data available for Paralogs for MIR489 Gene

Variants for MIR489 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR489 Gene

Variant ID Type Subtype PubMed ID
nsv888737 CNV Loss 21882294

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Variation tolerance and Relevant External Links for MIR489 Gene

Disorders for MIR489 Gene

Relevant External Links for MIR489

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR489 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR489 Gene

Publications for MIR489 Gene

  1. Down-regulation of miR-489 contributes into NSCLC cell invasion through targeting SUZ12. (PMID: 25833694) Xie Z. … Wang Z. (Tumour Biol. 2015) 3 67
  2. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 1 3
  3. MiR-489 modulates cisplatin resistance in human ovarian cancer cells by targeting Akt3. (PMID: 24686007) Wu H. … Hao Q. (Anticancer Drugs 2014) 3
  4. MiR-489 regulates chemoresistance in breast cancer via epithelial mesenchymal transition pathway. (PMID: 24786471) Jiang L. … Ma X. (FEBS Lett. 2014) 3
  5. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J. … Kaessmann H. (Genome Res. 2013) 3

Products for MIR489 Gene

Sources for MIR489 Gene