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Aliases for MIR488 Gene

Subcategory (RNA class) for MIR488 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR488 Gene

  • MicroRNA 488 2 3 5
  • Hsa-Mir-488 3
  • Mir-488 3
  • MIRN488 3

External Ids for MIR488 Gene

Previous HGNC Symbols for MIR488 Gene

  • MIRN488

Previous GeneCards Identifiers for MIR488 Gene

  • GC01M175266
  • GC01M176998

Summaries for MIR488 Gene

Entrez Gene Summary for MIR488 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR488 Gene

MIR488 (MicroRNA 488) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR488 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR488

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR488 Gene

Genomics for MIR488 Gene

Regulatory Elements for MIR488 Gene

Enhancers for MIR488 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIR488 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR488 Gene

Chromosome:
1
Start:
177,029,343 bp from pter
End:
177,029,452 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR488 Gene

Genes around MIR488 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR488 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR488 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR488 Gene

ORGUL Member Location for MIR488 Gene

ORGUL Member Location for MIR488 gene

Proteins for MIR488 Gene

Post-translational modifications for MIR488 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR488 Gene

Domains & Families for MIR488 Gene

Gene Families for MIR488 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR488: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR488 Gene

Function for MIR488 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR488 Gene

Localization for MIR488 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR488 Gene

Pathways & Interactions for MIR488 Gene

SuperPathways for MIR488 Gene

No Data Available

Interacting Proteins for MIR488 Gene

Gene Ontology (GO) - Biological Process for MIR488 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR488 Gene

Drugs & Compounds for MIR488 Gene

No Compound Related Data Available

Transcripts for MIR488 Gene

fRNAdb Secondary structures for MIR488 Gene

  • hsa-miR-488-5p_MIMAT0002804_Homo_sapiens_miR-488-5p_mature

mRNA/cDNA for MIR488 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR488 Gene

No ASD Table

Relevant External Links for MIR488 Gene

GeneLoc Exon Structure for
MIR488
ECgene alternative splicing isoforms for
MIR488

Expression for MIR488 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR488 Gene

Orthologs for MIR488 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR488 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-488 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-488 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir488 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-488 36
  • 99 (a)
OneToOne
Species with no ortholog for MIR488:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR488 Gene

ENSEMBL:
Gene Tree for MIR488 (if available)
TreeFam:
Gene Tree for MIR488 (if available)

Paralogs for MIR488 Gene

No data available for Paralogs for MIR488 Gene

Variants for MIR488 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for MIR488 Gene

Disorders for MIR488 Gene

Relevant External Links for MIR488

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR488

No disorders were found for MIR488 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR488 Gene

Publications for MIR488 Gene

  1. MicroRNA-488 regulates zinc transporter SLC39A8/ZIP8 during pathogenesis of osteoarthritis. (PMID: 23688035) Song J. … Jin E.J. (J. Biomed. Sci. 2013) 3 67
  2. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 1 3
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3
  4. Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways. (PMID: 21168126) MuiA+os-Gimeno M. … Estivill X. (Biol. Psychiatry 2011) 3
  5. miR 488* inhibits androgen receptor expression in prostate carcinoma cells. (PMID: 21710544) Sikand K. … Shukla G.C. (Int. J. Cancer 2011) 3

Products for MIR488 Gene

Sources for MIR488 Gene

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