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Aliases for MIR487B Gene

Subcategory (RNA class) for MIR487B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR487B Gene

  • MicroRNA 487b 2 3 5
  • Hsa-Mir-487b 3
  • Mir-487b 3
  • MIRN487B 3

External Ids for MIR487B Gene

ORGUL Members for MIR487B Gene

Previous HGNC Symbols for MIR487B Gene

  • MIRN487B

Previous GeneCards Identifiers for MIR487B Gene

  • GC14P100825
  • GC14P100915
  • GC14P101516
  • GC14P101545
  • GC14P101578
  • GC14P101619
  • GC14P101647
  • GC14P101680
  • GC14P101718
  • GC14P101760
  • GC14P101818
  • GC14P101958
  • GC14P102155
  • GC14P101257
  • GC14P101867
  • GC14P102186
  • GC14P102356
  • GC14P102526

Summaries for MIR487B Gene

Entrez Gene Summary for MIR487B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR487B Gene

MIR487B (MicroRNA 487b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR487B Gene

Genomics for MIR487B Gene

Regulatory Elements for MIR487B Gene

Enhancers for MIR487B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G101096 1.1 FANTOM5 ENCODE 10.7 +51.9 51893 3.2 CTCF SUZ12 JUN ZIC2 RAD21 ZNF335 GLIS2 ZNF366 GATA2 POLR2A RTL1 LOC105370670 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14G101215 1 ENCODE 9.9 +170.3 170270 2.8 HDGF FOXA2 ARID4B ZNF48 TCF12 GATA2 CAVIN1 ZNF592 SSRP1 ZNF658 DYNC1H1 YY1 SNORD113-3 SNORD113-6 SNORD113-7 SNORD113-4 SNORD113-8 SNORD113-9 MIR543 ENSG00000272444
GH14G101287 1 ENCODE 9.4 +242.5 242466 2.5 FOXA2 ATF1 MLX ZFP64 ARID4B ZNF48 YY1 SP5 ZHX2 NFYC MEG3 MIR1185-2 MIR381 MIR487B MIR539 MIR544A MIR889 MIR655 MIR1185-1 MIR300
GH14G101004 0.8 Ensembl ENCODE 10.9 -41.4 -41371 1.9 GATA3 MNT MYC ZIC2 TCF7L2 MIR134 MIR487A MIR154 MIR323B MIR485 MIR377 MIR496 MIR376C MIR1185-1 MIR1185-2
GH14G101330 0.9 ENCODE 8.9 +284.4 284400 0.3 ELF3 FOXA2 MLX ARID4B RAD21 THRB ZNF48 ZSCAN9 RARA CREM MIR1185-1 MIR1185-2 MIR300 MIR381 MIR487B MIR539 MIR544A MIR655 MIR889 MIR376C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR487B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR487B Gene

Chromosome:
14
Start:
101,046,455 bp from pter
End:
101,046,538 bp from pter
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR487B Gene

Genes around MIR487B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR487B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR487B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR487B Gene

Proteins for MIR487B Gene

Post-translational modifications for MIR487B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR487B Gene

Domains & Families for MIR487B Gene

Gene Families for MIR487B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR487B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR487B Gene

Function for MIR487B Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR487B Gene

Localization for MIR487B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR487B Gene

Pathways & Interactions for MIR487B Gene

SuperPathways for MIR487B Gene

No Data Available

Interacting Proteins for MIR487B Gene

Gene Ontology (GO) - Biological Process for MIR487B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR487B Gene

Drugs & Compounds for MIR487B Gene

No Compound Related Data Available

Transcripts for MIR487B Gene

mRNA/cDNA for MIR487B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR487B Gene

No ASD Table

Relevant External Links for MIR487B Gene

GeneLoc Exon Structure for
MIR487B
ECgene alternative splicing isoforms for
MIR487B

Expression for MIR487B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR487B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR487B Gene:

MIR487B
genes like me logo Genes that share expression patterns with MIR487B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR487B Gene

Orthologs for MIR487B Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR487B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-487b 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-487b 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-487b 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir487b 35
  • 93 (a)
OneToOne
Species where no ortholog for MIR487B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR487B Gene

ENSEMBL:
Gene Tree for MIR487B (if available)
TreeFam:
Gene Tree for MIR487B (if available)

Paralogs for MIR487B Gene

No data available for Paralogs for MIR487B Gene

Variants for MIR487B Gene

Sequence variations from dbSNP and Humsavar for MIR487B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000942364 -- 101,046,276(+) GTGGC(A/G)CTCGT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1002444581 -- 101,046,676(+) GTCCA(C/T)TTCTT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1002583356 -- 101,045,115(+) GACCC(A/G)AAGCC upstream-variant-2KB
rs1003662338 -- 101,045,775(+) TGACC(C/T)ATGGG intron-variant, upstream-variant-2KB
rs1003695067 -- 101,044,703(+) GCCAG(C/G/T)CCCAG downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR487B Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Relevant External Links for MIR487B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR487B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR487B Gene

Disorders for MIR487B Gene

Relevant External Links for MIR487B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR487B

No disorders were found for MIR487B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR487B Gene

Publications for MIR487B Gene

  1. Identification of microRNA-487b as a negative regulator of liver metastasis by regulation of KRAS in colorectal cancer. (PMID: 28000854) Hata T. … Yamamoto H. (Int. J. Oncol. 2017) 3 64
  2. miR-487b-5p Regulates Temozolomide Resistance of Lung Cancer Cells Through LAMP2-Medicated Autophagy. (PMID: 27097129) Bao L. … Zhao H. (DNA Cell Biol. 2016) 3 64
  3. miR-487b promotes human umbilical vein endothelial cell proliferation, migration, invasion and tube formation through regulating THBS1. (PMID: 25660232) Feng N. … Zhang L. (Neurosci. Lett. 2015) 3 64
  4. MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. (PMID: 24166498) Formosa A. … Candi E. (Oncogene 2014) 3 64
  5. MiR-134/487b/655 Cluster Regulates TGF-I^-Induced Epithelial-Mesenchymal Transition and Drug Resistance to Gefitinib by Targeting MAGI2 in Lung Adenocarcinoma Cells. (PMID: 24258346) Kitamura K. … Gemma A. (Mol. Cancer Ther. 2014) 3 64

Products for MIR487B Gene

Sources for MIR487B Gene

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