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Aliases for MIR486-1 Gene

Subcategory (RNA class) for MIR486-1 Gene


Quality Score for this RNA gene is


Aliases for MIR486-1 Gene

  • MicroRNA 486-1 2 3
  • MicroRNA 486 2 3
  • Hsa-Mir-486-1 3
  • Hsa-Mir-486 3
  • Mir-486-1 3
  • MIRN486 3
  • MIR486 3

External Ids for MIR486-1 Gene

Previous HGNC Symbols for MIR486-1 Gene

  • MIRN486
  • MIR486

Summaries for MIR486-1 Gene

Entrez Gene Summary for MIR486-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR486-1 Gene

MIR486-1 (MicroRNA 486-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRs in Muscle Cell Differentiation.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR486-1 Gene

Genomics for MIR486-1 Gene

Genomic Location for MIR486-1 Gene

41,660,414 bp from pter
41,660,525 bp from pter
112 bases
Minus strand

Genomic View for MIR486-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MIR486-1 Gene

No data available for Regulatory Elements for MIR486-1 Gene

Proteins for MIR486-1 Gene

Post-translational modifications for MIR486-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR486-1 Gene

Domains & Families for MIR486-1 Gene

Gene Families for MIR486-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR486-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR486-1 Gene

Function for MIR486-1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR486-1 Gene

Localization for MIR486-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR486-1 Gene

Pathways & Interactions for MIR486-1 Gene

genes like me logo Genes that share pathways with MIR486-1: view

Pathways by source for MIR486-1 Gene

1 BioSystems pathway for MIR486-1 Gene

Interacting Proteins for MIR486-1 Gene

Gene Ontology (GO) - Biological Process for MIR486-1 Gene


No data available for SIGNOR curated interactions for MIR486-1 Gene

Drugs & Compounds for MIR486-1 Gene

No Compound Related Data Available

Transcripts for MIR486-1 Gene

mRNA/cDNA for MIR486-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR486-1 Gene

No ASD Table

Relevant External Links for MIR486-1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR486-1 Gene

mRNA expression in normal human tissues for MIR486-1 Gene

genes like me logo Genes that share expression patterns with MIR486-1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR486-1 Gene

Orthologs for MIR486-1 Gene

Evolution for MIR486-1 Gene

Gene Tree for MIR486-1 (if available)
Gene Tree for MIR486-1 (if available)

No data available for Orthologs for MIR486-1 Gene

Paralogs for MIR486-1 Gene

No data available for Paralogs for MIR486-1 Gene

Variants for MIR486-1 Gene

Relevant External Links for MIR486-1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR486-1 Gene

Disorders for MIR486-1 Gene

Relevant External Links for MIR486-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR486-1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR486-1 Gene

Publications for MIR486-1 Gene

  1. MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome. (PMID: 25533034) Shaham L. … Izraeli S. (Blood 2015) 67
  2. MicroRNA-486 regulates normal erythropoiesis and enhances growth and modulates drug response in CML progenitors. (PMID: 25515961) Wang L.S. … Bhatia R. (Blood 2015) 67
  3. Differential expression of miR-139, miR-486 and miR-21 in breast cancer patients sub-classified according to lymph node status. (PMID: 25027758) Rask L. … Litman T. (Cell Oncol (Dordr) 2014) 67
  4. Pim-1 kinase is a target of miR-486-5p and eukaryotic translation initiation factor 4E, and plays a critical role in lung cancer. (PMID: 25342548) Pang W. … Xing L. (Mol. Cancer 2014) 67
  5. MicroRNA-486-5p targeting PIM-1 suppresses cell proliferation in breast cancer cells. (PMID: 25104088) Zhang G. … Yang Z. (Tumour Biol. 2014) 67

Products for MIR486-1 Gene

Sources for MIR486-1 Gene

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