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Aliases for MIR486-1 Gene

Subcategory (RNA class) for MIR486-1 Gene


Quality Score for this RNA gene is


Aliases for MIR486-1 Gene

  • MicroRNA 486-1 2 3 5
  • MicroRNA 486 2 3
  • Hsa-Mir-486-1 3
  • Hsa-Mir-486 3
  • Mir-486-1 3
  • MIRN486 3
  • MIR486 3

External Ids for MIR486-1 Gene

Previous HGNC Symbols for MIR486-1 Gene

  • MIRN486
  • MIR486

Summaries for MIR486-1 Gene

Entrez Gene Summary for MIR486-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR486-1 Gene

MIR486-1 (MicroRNA 486-1) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR486-1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR486-1 Gene

Genomics for MIR486-1 Gene

Genomic Locations for MIR486-1 Gene

Genomic Locations for MIR486-1 Gene
68 bases
Minus strand

Genomic View for MIR486-1 Gene

Genes around MIR486-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR486-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR486-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR486-1 Gene

No data available for Regulatory Elements for MIR486-1 Gene

Proteins for MIR486-1 Gene

Post-translational modifications for MIR486-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR486-1 Gene

Domains & Families for MIR486-1 Gene

Gene Families for MIR486-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR486-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR486-1 Gene

Function for MIR486-1 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR486-1 Gene

Localization for MIR486-1 Gene

Gene Ontology (GO) - Cellular Components for MIR486-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR486-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR486-1 Gene

Pathways & Interactions for MIR486-1 Gene

SuperPathways for MIR486-1 Gene

No Data Available

Interacting Proteins for MIR486-1 Gene

Gene Ontology (GO) - Biological Process for MIR486-1 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR486-1 Gene

Drugs & Compounds for MIR486-1 Gene

No Compound Related Data Available

Transcripts for MIR486-1 Gene

mRNA/cDNA for MIR486-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR486-1 Gene

No ASD Table

Relevant External Links for MIR486-1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR486-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR486-1 Gene

genes like me logo Genes that share expression patterns with MIR486-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR486-1 Gene

Orthologs for MIR486-1 Gene

Evolution for MIR486-1 Gene

Gene Tree for MIR486-1 (if available)
Gene Tree for MIR486-1 (if available)

No data available for Orthologs for MIR486-1 Gene

Paralogs for MIR486-1 Gene

No data available for Paralogs for MIR486-1 Gene

Variants for MIR486-1 Gene

Sequence variations from dbSNP and Humsavar for MIR486-1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs137852831 Pathogenic 41,661,923(-) TGGTT(C/T)GACAG intron-variant, upstream-variant-2KB, reference, stop-gained
rs515071 Likely benign 41,661,944(-) TTTCC(A/C/T)AGATC intron-variant, upstream-variant-2KB
rs145235970 Uncertain significance 41,661,495(+) GGCCC(A/G)CTTCA intron-variant, upstream-variant-2KB, reference, missense
rs201561226 Uncertain significance 41,661,462(+) GGCTC(A/C/G)GGGTC intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs72638959 Benign 41,661,785(+) GGGCC(A/G)CGGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR486-1 Gene

Variant ID Type Subtype PubMed ID
nsv831299 CNV loss 17160897
esv3576565 CNV gain 25503493

Relevant External Links for MIR486-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR486-1 Gene

Disorders for MIR486-1 Gene

Relevant External Links for MIR486-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR486-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR486-1 Gene

Publications for MIR486-1 Gene

  1. MiR-142-5p and miR-486-5p as biomarkers for early detection of chronic antibody-mediated rejection in kidney transplantation. (PMID: 27323802) Iwasaki K … Kobayashi T (Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2017) 3 60
  2. Exosomal miR-486 regulates hypoxia-induced erythroid differentiation of erythroleukemia cells through targeting Sirt1. (PMID: 28043832) Shi XF … Wang LS (Experimental cell research 2017) 3 60
  3. mir-660-p53-mir-486 Network: A New Key Regulatory Pathway in Lung Tumorigenesis. (PMID: 28124991) Borzi C … Fortunato O (International journal of molecular sciences 2017) 3 60
  4. Profile of 6 microRNA in blood plasma distinguish early stage Alzheimer's disease patients from non-demented subjects. (PMID: 28179587) Nagaraj S … Wojda U (Oncotarget 2017) 3 60
  5. miR-486 suppresses the development of osteosarcoma by regulating PKC-δ pathway. (PMID: 28339053) He M … Fu Y (International journal of oncology 2017) 3 60

Products for MIR486-1 Gene

Sources for MIR486-1 Gene

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