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Aliases for MIR486-1 Gene

Subcategory (RNA class) for MIR486-1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR486-1 Gene

  • MicroRNA 486-1 2 3 5
  • MicroRNA 486 2 3
  • Hsa-Mir-486-1 3
  • Hsa-Mir-486 3
  • Mir-486-1 3
  • MIRN486 3
  • MIR486 3

External Ids for MIR486-1 Gene

Previous HGNC Symbols for MIR486-1 Gene

  • MIRN486
  • MIR486

Summaries for MIR486-1 Gene

Entrez Gene Summary for MIR486-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR486-1 Gene

MIR486-1 (MicroRNA 486-1) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR486-1 Gene

Genomics for MIR486-1 Gene

Genomic Location for MIR486-1 Gene

Chromosome:
8
Start:
41,660,441 bp from pter
End:
41,660,508 bp from pter
Size:
68 bases
Orientation:
Minus strand

Genomic View for MIR486-1 Gene

Genes around MIR486-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR486-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR486-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR486-1 Gene

No data available for Regulatory Elements for MIR486-1 Gene

Proteins for MIR486-1 Gene

Post-translational modifications for MIR486-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR486-1 Gene

Domains & Families for MIR486-1 Gene

Gene Families for MIR486-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR486-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR486-1 Gene

Function for MIR486-1 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR486-1 Gene

Localization for MIR486-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR486-1 Gene

Pathways & Interactions for MIR486-1 Gene

SuperPathways for MIR486-1 Gene

No Data Available

Interacting Proteins for MIR486-1 Gene

Gene Ontology (GO) - Biological Process for MIR486-1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR486-1 Gene

Transcripts for MIR486-1 Gene

mRNA/cDNA for MIR486-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR486-1 Gene

No ASD Table

Relevant External Links for MIR486-1 Gene

GeneLoc Exon Structure for
MIR486-1
ECgene alternative splicing isoforms for
MIR486-1

Expression for MIR486-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR486-1 Gene

genes like me logo Genes that share expression patterns with MIR486-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR486-1 Gene

Orthologs for MIR486-1 Gene

Evolution for MIR486-1 Gene

ENSEMBL:
Gene Tree for MIR486-1 (if available)
TreeFam:
Gene Tree for MIR486-1 (if available)

No data available for Orthologs for MIR486-1 Gene

Paralogs for MIR486-1 Gene

No data available for Paralogs for MIR486-1 Gene

Variants for MIR486-1 Gene

Sequence variations from dbSNP and Humsavar for MIR486-1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs137852831 Pathogenic 41,661,923(-) TGGTT(C/T)GACAG intron-variant, upstream-variant-2KB, reference, stop-gained
rs515071 Benign 41,661,944(-) TTTCC(C/T)AGATC intron-variant, upstream-variant-2KB
rs72638959 Benign 41,661,785(+) GGGCC(A/G)CGGGC intron-variant, upstream-variant-2KB
rs1060131 -- 41,661,868(-) GACTG(A/T)AGAGG intron-variant, upstream-variant-2KB, reference, missense
rs1060132 -- 41,661,865(-) TGTAG(A/C/G)GGGGC intron-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MIR486-1 Gene

Variant ID Type Subtype PubMed ID
esv3576565 CNV gain 25503493
nsv831299 CNV loss 17160897

Relevant External Links for MIR486-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR486-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR486-1 Gene

Disorders for MIR486-1 Gene

Relevant External Links for MIR486-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR486-1

No disorders were found for MIR486-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR486-1 Gene

Publications for MIR486-1 Gene

  1. MiR-486 regulates cholesterol efflux by targeting HAT1. (PMID: 26654953) Liu D. … Tang C.K. (Biochem. Biophys. Res. Commun. 2016) 3 64
  2. MiRNA-486 regulates angiogenic activity and survival of mesenchymal stem cells under hypoxia through modulating Akt signal. (PMID: 26801559) Shi X.F. … Wang L.S. (Biochem. Biophys. Res. Commun. 2016) 3 64
  3. miR-483-5p and miR-486-5p are down-regulated in cumulus cells of metaphase II oocytes from women with polycystic ovary syndrome. (PMID: 26283014) Shi L. … Shi J. (Reprod. Biomed. Online 2015) 3 64
  4. MicroRNA-486 regulates normal erythropoiesis and enhances growth and modulates drug response in CML progenitors. (PMID: 25515961) Wang L.S. … Bhatia R. (Blood 2015) 3 64
  5. MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome. (PMID: 25533034) Shaham L. … Izraeli S. (Blood 2015) 3 64

Products for MIR486-1 Gene

Sources for MIR486-1 Gene

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