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Aliases for MIR485 Gene

Subcategory (RNA class) for MIR485 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR485 Gene

  • MicroRNA 485 2 3 5
  • Hsa-Mir-485 3
  • Mir-485 3
  • MIRN485 3

External Ids for MIR485 Gene

ORGUL Members for MIR485 Gene

Previous HGNC Symbols for MIR485 Gene

  • MIRN485

Previous GeneCards Identifiers for MIR485 Gene

  • GC14P100834
  • GC14P100924
  • GC14P101525
  • GC14P101554
  • GC14P101589
  • GC14P101628
  • GC14P101656
  • GC14P101690
  • GC14P101728
  • GC14P101768
  • GC14P101826
  • GC14P101966
  • GC14P102163
  • GC14P101267
  • GC14P101876
  • GC14P102199
  • GC14P102367
  • GC14P102537

Summaries for MIR485 Gene

Entrez Gene Summary for MIR485 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR485 Gene

MIR485 (MicroRNA 485) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR485 Gene

Genomics for MIR485 Gene

Regulatory Elements for MIR485 Gene

Enhancers for MIR485 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G101096 1.1 FANTOM5 ENCODE 10.9 +42.9 42929 3.2 CTCF SUZ12 JUN ZIC2 RAD21 ZNF335 GLIS2 ZNF366 GATA2 POLR2A RTL1 LOC105370670 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14G101004 0.8 Ensembl ENCODE 11 -50.3 -50335 1.9 GATA3 MNT MYC ZIC2 TCF7L2 MIR134 MIR487A MIR323B MIR485 MIR154 MIR377 MIR496 MIR376C MIR1185-1 MIR1185-2
GH14G101176 0.6 ENCODE 10.7 +121.9 121948 2.0 ZNF680 ZFP3 ZBTB33 REST FOXP2 ZNF507 MIR377 MIR496 MIR154 MIR323B MIR485 MIR487A MIR134 SNORD113-2 SNORD113-3 ENSG00000222185
GH14G101008 0.4 ENCODE 11 -46.7 -46721 0.2 ZNF263 KDM1A MIR487A MIR134 MIR323B MIR485 MIR377 MIR496 MIR154 MIR1185-1 MIR376C MIR654
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR485 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR485 Gene

Chromosome:
14
Start:
101,055,419 bp from pter
End:
101,055,491 bp from pter
Size:
73 bases
Orientation:
Plus strand

Genomic View for MIR485 Gene

Genes around MIR485 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR485 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR485 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR485 Gene

Proteins for MIR485 Gene

Post-translational modifications for MIR485 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR485 Gene

Domains & Families for MIR485 Gene

Gene Families for MIR485 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR485: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR485 Gene

Function for MIR485 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR485 Gene

Localization for MIR485 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR485 Gene

Pathways & Interactions for MIR485 Gene

SuperPathways for MIR485 Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR485: view

Pathways by source for MIR485 Gene

1 BioSystems pathway for MIR485 Gene

Interacting Proteins for MIR485 Gene

Gene Ontology (GO) - Biological Process for MIR485 Gene

None

No data available for SIGNOR curated interactions for MIR485 Gene

Drugs & Compounds for MIR485 Gene

No Compound Related Data Available

Transcripts for MIR485 Gene

mRNA/cDNA for MIR485 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR485 Gene

No ASD Table

Relevant External Links for MIR485 Gene

GeneLoc Exon Structure for
MIR485
ECgene alternative splicing isoforms for
MIR485

Expression for MIR485 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR485 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR485 Gene:

MIR485
genes like me logo Genes that share expression patterns with MIR485: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR485 Gene

Orthologs for MIR485 Gene

Evolution for MIR485 Gene

ENSEMBL:
Gene Tree for MIR485 (if available)
TreeFam:
Gene Tree for MIR485 (if available)

No data available for Orthologs for MIR485 Gene

Paralogs for MIR485 Gene

No data available for Paralogs for MIR485 Gene

Variants for MIR485 Gene

Sequence variations from dbSNP and Humsavar for MIR485 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1001787824 -- 101,053,450(+) GAAAG(A/G)GGTAA upstream-variant-2KB
rs1002933201 -- 101,054,171(+) CCAGT(C/G)TGTTC upstream-variant-2KB
rs1003488050 -- 101,054,234(+) GGATG(A/G)TGGTT upstream-variant-2KB
rs1003864116 -- 101,054,505(+) TAGCT(G/T)TAAGT downstream-variant-500B, upstream-variant-2KB
rs1005576245 -- 101,055,284(+) CATGC(A/G)CTTAA nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR485 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Relevant External Links for MIR485 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR485

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR485 Gene

Disorders for MIR485 Gene

Relevant External Links for MIR485

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR485

No disorders were found for MIR485 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR485 Gene

Publications for MIR485 Gene

  1. MiR-485-3p and miR-485-5p suppress breast cancer cell metastasis by inhibiting PGC-1I+ expression. (PMID: 27010860) Lou C. … Li Z. (Cell Death Dis 2016) 3 64
  2. Multiple myeloma cells alter the senescence phenotype of bone marrow mesenchymal stromal cells under participation of the DLK1-DIO3 genomic region. (PMID: 25886144) Berenstein R. … Blau I.W. (BMC Cancer 2015) 3 64
  3. Involvement of miR-485-5p in hepatocellular carcinoma progression targeting EMMPRIN. (PMID: 26054676) Sun X. … Wang Y. (Biomed. Pharmacother. 2015) 3 64
  4. Expression profile analysis of microRNAs and downregulated miR-486-5p and miR-30a-5p in non-small cell lung cancer. (PMID: 26238736) Zhu J. … Huang J.A. (Oncol. Rep. 2015) 3 64
  5. MicroRNA-485-5p suppresses cell proliferation and invasion in hepatocellular carcinoma by targeting stanniocalcin 2. (PMID: 26722415) Guo G.X. … Ren X.Q. (Int J Clin Exp Pathol 2015) 3 64

Products for MIR485 Gene

Sources for MIR485 Gene

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