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Aliases for MIR484 Gene

Subcategory (RNA class) for MIR484 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR484 Gene

  • MicroRNA 484 2 3
  • NDE1 4 5
  • NudE Neurodevelopment Protein 1 5
  • Hsa-Mir-484 3
  • Mir-484 3
  • MIRN484 3
  • NUDE 4

External Ids for MIR484 Gene

Previous HGNC Symbols for MIR484 Gene

  • MIRN484

Previous GeneCards Identifiers for MIR484 Gene

  • GC16P015645
  • GC16P015737

Summaries for MIR484 Gene

Entrez Gene Summary for MIR484 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR484 Gene

MIR484 (MicroRNA 484) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR484 include Lissencephaly 4 and Microhydranencephaly. An important paralog of this gene is NDEL1.

UniProtKB/Swiss-Prot for MIR484 Gene

  • Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR484 Gene

Genomics for MIR484 Gene

Regulatory Elements for MIR484 Gene


Promoters for MIR484 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR484 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR484 Gene

Chromosome:
16
Start:
15,643,267 bp from pter
End:
15,726,353 bp from pter
Size:
83,087 bases
Orientation:
Plus strand

Genomic View for MIR484 Gene

Genes around MIR484 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR484 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR484 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR484 Gene

Proteins for MIR484 Gene

  • Protein details for MIR484 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXR1-NDE1_HUMAN
    Recommended name:
    Nuclear distribution protein nudE homolog 1
    Protein Accession:
    Q9NXR1
    Secondary Accessions:
    • Q49AQ2

    Protein attributes for MIR484 Gene

    Size:
    346 amino acids
    Molecular mass:
    38808 Da
    Quaternary structure:
    • Self-associates. Interacts with CNTRL, LIS1, dynein, SLMAP and TCP1 (By similarity). Interacts with CENPF, dynactin, tubulin gamma, PAFAH1B1, PCM1 and PCNT. Interacts with ZNF365.
    • Self-associates. Interacts with CNTRL, LIS1, dynein, SLMAP and TCP1 (By similarity). Interacts with CENPF, dynactin, tubulin gamma, PAFAH1B1, PCM1 and PCNT. Interacts with ZNF365.

    Alternative splice isoforms for MIR484 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR484 Gene

Post-translational modifications for MIR484 Gene

  • Phosphorylated in mitosis. Phosphorylated in vitro by CDC2. Phosphorylation at Thr-246 is essential for the G2/M transition (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIR484 Gene

Domains & Families for MIR484 Gene

Gene Families for MIR484 Gene

Protein Domains for MIR484 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NXR1

UniProtKB/Swiss-Prot:

NDE1_HUMAN :
  • Belongs to the nudE family.
Family:
  • Belongs to the nudE family.
genes like me logo Genes that share domains with MIR484: view

No data available for Suggested Antigen Peptide Sequences for MIR484 Gene

Function for MIR484 Gene

Molecular function for MIR484 Gene

UniProtKB/Swiss-Prot Function:
Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex.

Gene Ontology (GO) - Molecular Function for MIR484 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
GO:0008017 microtubule binding ISS --
GO:0019904 protein domain specific binding IEA --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with MIR484: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR484 Gene

Localization for MIR484 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR484 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Note=Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF-dependent manner. Also localizes to the cleavage furrow during cytokinesis. manner. Also localizes to the cleavage furrow during cytokinesis.

Gene Ontology (GO) - Cellular Components for MIR484 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005813 centrosome IDA --
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with MIR484: view

No data available for Subcellular locations from COMPARTMENTS for MIR484 Gene

Pathways & Interactions for MIR484 Gene

SuperPathways for MIR484 Gene

No Data Available

Interacting Proteins for MIR484 Gene

Gene Ontology (GO) - Biological Process for MIR484 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IMP --
GO:0001764 neuron migration IEA --
GO:0007020 microtubule nucleation IBA --
GO:0007059 chromosome segregation IBA --
GO:0007062 sister chromatid cohesion TAS --
genes like me logo Genes that share ontologies with MIR484: view

No data available for Pathways by source and SIGNOR curated interactions for MIR484 Gene

Drugs & Compounds for MIR484 Gene

No Compound Related Data Available

Transcripts for MIR484 Gene

mRNA/cDNA for MIR484 Gene

(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR484 Gene

No ASD Table

Relevant External Links for MIR484 Gene

GeneLoc Exon Structure for
MIR484
ECgene alternative splicing isoforms for
MIR484

Expression for MIR484 Gene

mRNA expression in normal human tissues for MIR484 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR484 Gene:

MIR484

mRNA Expression by UniProt/SwissProt for MIR484 Gene:

Q9NXR1-NDE1_HUMAN
Tissue specificity: Expressed in the neuroepithelium throughout the developing brain, including the cerebral cortex and cerebellum.
genes like me logo Genes that share expression patterns with MIR484: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR484 Gene

Orthologs for MIR484 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR484 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDE1 35
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDE1 35
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDE1 35
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nde1 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDE1 35
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NDE1 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDE1 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDE1 35
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nde1 35
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nudE 35
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8970 35
  • 41 (a)
OneToMany
Species where no ortholog for MIR484 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR484 Gene

ENSEMBL:
Gene Tree for MIR484 (if available)
TreeFam:
Gene Tree for MIR484 (if available)

Paralogs for MIR484 Gene

Paralogs for MIR484 Gene

Pseudogenes.org Pseudogenes for MIR484 Gene

genes like me logo Genes that share paralogs with MIR484: view

Variants for MIR484 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR484 Gene

Variant ID Type Subtype PubMed ID
dgv4924n54 CNV gain 21841781
esv2714015 CNV deletion 23290073
nsv1047898 CNV loss 25217958
nsv1049647 CNV gain+loss 25217958
nsv1125134 CNV deletion 24896259
nsv435664 CNV deletion 17901297
nsv457428 CNV gain 19166990
nsv469626 CNV loss 16826518

Relevant External Links for MIR484 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR484

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR484 Gene

Disorders for MIR484 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR484 Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
lissencephaly 4
  • lis4
microhydranencephaly
  • mhac
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

NDE1_HUMAN
  • Lissencephaly 4 (LIS4) [MIM:614019]: A neurodevelopmental disorder characterized by lissencephaly, severe brain atrophy, extreme microcephaly, and profound mental retardation. {ECO:0000269 PubMed:21529751, ECO:0000269 PubMed:21529752}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Microhydranencephaly (MHAC) [MIM:605013]: A severe neurodevelopmental disorder characterized by microcephaly, severe motor and mental retardation, spasticity, and brain malformations that include gross dilation of the ventricles with complete absence of the cerebral hemispheres or severe delay in their development. {ECO:0000269 PubMed:22526350}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR484

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR484
genes like me logo Genes that share disorders with MIR484: view

No data available for Genatlas for MIR484 Gene

Publications for MIR484 Gene

  1. Cytidine Deaminase Axis Modulated by miR-484 Differentially Regulates Cell Proliferation and Chemoresistance in Breast Cancer. (PMID: 25643696) Ye F.G. … Shao Z.M. (Cancer Res. 2015) 3 65
  2. The significance of detection of serum miR-423-5p and miR-484 for diagnosis of colorectal cancer. (PMID: 25807655) Lu X. … Lu J. (Clin. Lab. 2015) 3 65
  3. The regulatory interaction of EVI1 with the TCL1A oncogene impacts cell survival and clinical outcome in CLL. (PMID: 25936528) Vasyutina E. … Herling M. (Leukemia 2015) 3 65
  4. miR-155 and miR-484 Are Associated with Time to Progression in Metastatic Renal Cell Carcinoma Treated with Sunitinib. (PMID: 26064968) Merhautova J. … Slaby O. (Biomed Res Int 2015) 3 65
  5. MicroRNA-484 is more highly expressed in serum of early breast cancer patients compared to healthy volunteers. (PMID: 24641801) Zearo S. … Soon P.S.h. (BMC Cancer 2014) 3 65

Products for MIR484 Gene

Sources for MIR484 Gene

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