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Aliases for MIR483 Gene

Subcategory (RNA class) for MIR483 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR483 Gene

  • MicroRNA 483 2 3 5
  • Hsa-Mir-483 3
  • Mir-483 3
  • MIRN483 3

External Ids for MIR483 Gene

Previous HGNC Symbols for MIR483 Gene

  • MIRN483

Previous GeneCards Identifiers for MIR483 Gene

  • GC11M002115
  • GC11M002117
  • GC11M002155
  • GC11M002136
  • GC11M002138
  • GC11M002139
  • GC11M002146

Summaries for MIR483 Gene

Entrez Gene Summary for MIR483 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR483 Gene

MIR483 (MicroRNA 483) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR483 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR483

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR483 Gene

Genomics for MIR483 Gene

Regulatory Elements for MIR483 Gene

Enhancers for MIR483 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F002095 1.2 Ensembl ENCODE 12.2 +37.4 37391 3.6 ELF3 TBP CBX3 MLX ARID4B DMAP1 THRB ZNF48 ZSCAN9 RARA MIR483 IGF2-AS IGF2 GC11P002077 ENSG00000240801
GH11F002108 1.1 Ensembl ENCODE 12.6 +24.8 24755 1.5 CTCF ELF3 TFAP4 SAP130 ZFP64 MAX RAD21 ZNF48 TEAD3 GLIS2 MIR483 IGF2-AS IGF2 TNNT3 TH ENSG00000240801 GC11P002077
GH11F002076 1.2 Ensembl ENCODE 11.4 +56.7 56683 1.8 MLX ARID4B DMAP1 ZNF48 SLC30A9 GLIS2 FOS MXD4 MIER2 NFIL3 MIR483 IGF2-AS IGF2 TNNI2 SYT8 GC11P002077 GC11M002043
GH11F002099 1 Ensembl ENCODE 12.6 +34.2 34209 2.0 CTCF KLF1 ATF1 SAP130 ARID4B ZIC2 GLIS2 CREM THAP11 GATAD2A ENSG00000240801 MIR483 IGF2-AS IGF2 GC11P002077
GH11F002178 1.1 FANTOM5 Ensembl ENCODE 11.3 -44.6 -44632 1.4 ZFHX2 PKNOX1 MNT FOS TCF7L2 EGR2 IGF2 TH IGF2-AS MIR483 ENSG00000236710 ASCL2 SYT8 MIR4686 GC11M002206
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR483 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR483 Gene

Chromosome:
11
Start:
2,134,134 bp from pter
End:
2,134,209 bp from pter
Size:
76 bases
Orientation:
Minus strand

Genomic View for MIR483 Gene

Genes around MIR483 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR483 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR483 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR483 Gene

ORGUL Member Location for MIR483 Gene

ORGUL Member Location for MIR483 gene

Proteins for MIR483 Gene

Post-translational modifications for MIR483 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR483 Gene

Domains & Families for MIR483 Gene

Gene Families for MIR483 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR483: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR483 Gene

Function for MIR483 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR483 Gene

Localization for MIR483 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR483 Gene

Pathways & Interactions for MIR483 Gene

SuperPathways for MIR483 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR483: view

Pathways by source for MIR483 Gene

1 KEGG pathway for MIR483 Gene

Interacting Proteins for MIR483 Gene

Gene Ontology (GO) - Biological Process for MIR483 Gene

None

No data available for SIGNOR curated interactions for MIR483 Gene

Transcripts for MIR483 Gene

fRNAdb Secondary structures for MIR483 Gene

  • hsa-mir-483_MI0002467_Homo_sapiens_miR-483_stem-loop_hairpin

mRNA/cDNA for MIR483 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR483 Gene

No ASD Table

Relevant External Links for MIR483 Gene

GeneLoc Exon Structure for
MIR483
ECgene alternative splicing isoforms for
MIR483

Expression for MIR483 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR483 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR483 Gene:

MIR483
genes like me logo Genes that share expression patterns with MIR483: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR483 Gene

Orthologs for MIR483 Gene

Evolution for MIR483 Gene

ENSEMBL:
Gene Tree for MIR483 (if available)
TreeFam:
Gene Tree for MIR483 (if available)

No data available for Orthologs for MIR483 Gene

Paralogs for MIR483 Gene

No data available for Paralogs for MIR483 Gene

Variants for MIR483 Gene

Sequence variations from dbSNP and Humsavar for MIR483 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs869320620 Pathogenic 2,135,501(-) GAAGT(A/C)GATGC nc-transcript-variant, upstream-variant-2KB, reference, stop-gained
rs111395171 -- 2,135,158(+) ACCCT(C/T)CGAAG intron-variant, upstream-variant-2KB
rs111656313 -- 2,135,365(+) TACTT(A/G)CTGAA upstream-variant-2KB, splice-donor-variant
rs112018068 -- 2,134,590(+) TAAAG(A/G)TGTCA intron-variant, upstream-variant-2KB
rs112276039 -- 2,135,460(+) AATGC(A/G)GCACG nc-transcript-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MIR483 Gene

Variant ID Type Subtype PubMed ID
nsv467645 CNV gain 19166990
nsv553047 CNV gain 21841781
nsv553068 CNV loss 21841781
nsv825707 CNV gain 20364138
nsv951284 CNV deletion 24416366

Relevant External Links for MIR483 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR483

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR483 Gene

Disorders for MIR483 Gene

Relevant External Links for MIR483

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR483

No disorders were found for MIR483 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR483 Gene

Publications for MIR483 Gene

  1. Identification of human fetal liver miRNAs by a novel method. (PMID: 15978578) Fu H. … Zheng X. (FEBS Lett. 2005) 1 3 64
  2. miR-483-3p plays an oncogenic role in esophageal squamous cell carcinoma by targeting tumor suppressor EI24. (PMID: 26801660) Ma J. … Fan D. (Cell Biol. Int. 2016) 3 64
  3. Upregulation of miR-483-3p contributes to endothelial progenitor cells dysfunction in deep vein thrombosis patients via SRF. (PMID: 26801758) Kong L. … Li C. (J Transl Med 2016) 3 64
  4. Extracellular metabolic energetics can promote cancer progression. (PMID: 25601461) Loo J.M. … Tavazoie S.F. (Cell 2015) 3 64
  5. Characterization of microRNA profile in human cumulus granulosa cells: Identification of microRNAs that regulate Notch signaling and are associated with PCOS. (PMID: 25622783) Xu B. … Liu Y.S. (Mol. Cell. Endocrinol. 2015) 3 64

Products for MIR483 Gene

Sources for MIR483 Gene

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