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Aliases for MIR483 Gene

Subcategory (RNA class) for MIR483 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR483 Gene

  • MicroRNA 483 2 3 5
  • Hsa-Mir-483 3
  • Mir-483 3
  • MIRN483 3

External Ids for MIR483 Gene

Previous HGNC Symbols for MIR483 Gene

  • MIRN483

Previous GeneCards Identifiers for MIR483 Gene

  • GC11M002115
  • GC11M002117
  • GC11M002155
  • GC11M002136
  • GC11M002138
  • GC11M002139
  • GC11M002146
  • GC11M002148
  • GC11M002154

Summaries for MIR483 Gene

Entrez Gene Summary for MIR483 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR483 Gene

MIR483 (MicroRNA 483) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR483 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR483

Additional gene information for MIR483 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR483 Gene

Genomics for MIR483 Gene

Regulatory Elements for MIR483 Gene

Enhancers for MIR483 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H002095 1.2 Ensembl ENCODE 12.2 +37.4 37391 3.6 ELF3 TBP MLX ARID4B DMAP1 THRB ZSCAN9 RARA SLC30A9 MIXL1 MIR483 IGF2-AS IGF2 GC11P002077 ENSG00000240801
GH11H002108 1 Ensembl ENCODE 12.6 +24.8 24755 1.5 ELF3 GATAD2A TFAP4 SAP130 RNF2 MAX RAD21 TEAD3 KAT8 ZGPAT MIR483 IGF2-AS IGF2 TNNT3 TH ENSG00000240801 GC11P002077
GH11H002099 0.9 Ensembl ENCODE 12.6 +34.1 34074 1.6 CTCF ATF1 ZIC2 ATF2 RFX5 GABPA GLIS1 ATF7 ZBTB33 CREM ENSG00000240801 MIR483 IGF2-AS IGF2 GC11P002077
GH11H002178 1 FANTOM5 ENCODE dbSUPER 11.3 -44.9 -44892 0.5 PKNOX1 ZSCAN4 FOS IGF2 TH IGF2-AS MIR483 ENSG00000236710 ASCL2 SYT8 MIR4686 GC11M002206
GH11H002076 0.9 Ensembl ENCODE 11.4 +56.7 56683 1.8 JUN ZNF384 DPF2 FOXA1 CTBP1 JUND PRDM6 GATA3 FOSL2 FOS MIR483 IGF2-AS IGF2 SYT8 TNNI2 GC11P002077 GC11M002043
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR483 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR483 Gene

Genomic Locations for MIR483 Gene
chr11:2,134,134-2,134,209
(GRCh38/hg38)
Size:
76 bases
Orientation:
Minus strand
chr11:2,155,364-2,155,439
(GRCh37/hg19)

Genomic View for MIR483 Gene

Genes around MIR483 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR483 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR483 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR483 Gene

ORGUL Member Location for MIR483 Gene

ORGUL Member Location for MIR483 gene

Proteins for MIR483 Gene

Post-translational modifications for MIR483 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR483 Gene

Domains & Families for MIR483 Gene

Gene Families for MIR483 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR483: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR483 Gene

Function for MIR483 Gene

Phenotypes From GWAS Catalog for MIR483 Gene

Gene Ontology (GO) - Molecular Function for MIR483 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22223106
genes like me logo Genes that share ontologies with MIR483: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR483 Gene

Localization for MIR483 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR483 Gene

Pathways & Interactions for MIR483 Gene

SuperPathways for MIR483 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR483: view

Pathways by source for MIR483 Gene

1 KEGG pathway for MIR483 Gene

Interacting Proteins for MIR483 Gene

Gene Ontology (GO) - Biological Process for MIR483 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 22223106
GO:0045599 negative regulation of fat cell differentiation ISS --
genes like me logo Genes that share ontologies with MIR483: view

No data available for SIGNOR curated interactions for MIR483 Gene

Drugs & Compounds for MIR483 Gene

No Compound Related Data Available

Transcripts for MIR483 Gene

fRNAdb Secondary structures for MIR483 Gene

  • hsa-mir-483_MI0002467_Homo_sapiens_miR-483_stem-loop_hairpin

mRNA/cDNA for MIR483 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR483 Gene

No ASD Table

Relevant External Links for MIR483 Gene

GeneLoc Exon Structure for
MIR483
ECgene alternative splicing isoforms for
MIR483

Expression for MIR483 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR483 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR483 Gene:

MIR483
genes like me logo Genes that share expression patterns with MIR483: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR483 Gene

Orthologs for MIR483 Gene

Evolution for MIR483 Gene

ENSEMBL:
Gene Tree for MIR483 (if available)
TreeFam:
Gene Tree for MIR483 (if available)

No data available for Orthologs for MIR483 Gene

Paralogs for MIR483 Gene

No data available for Paralogs for MIR483 Gene

Variants for MIR483 Gene

Sequence variations from dbSNP and Humsavar for MIR483 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs553443857 Pathogenic 2,135,425(+) CCGCC(A/G/T)CACAG nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon
rs869320620 Pathogenic 2,135,501(-) GAAGT(A/C)GATGC nc-transcript-variant, upstream-variant-2KB, reference, stop-gained
rs1057518115 Likely pathogenic 2,135,427(-) CCCTG(C/T)GCGGC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1001954193 -- 2,135,113(+) AGACC(A/C)CTGTG intron-variant, upstream-variant-2KB
rs1001964091 -- 2,134,875(+) TGCAC(C/T)GCTCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR483 Gene

Variant ID Type Subtype PubMed ID
nsv951284 CNV deletion 24416366
nsv825707 CNV gain 20364138
nsv553068 CNV loss 21841781
nsv553047 CNV gain 21841781
nsv467645 CNV gain 19166990

Relevant External Links for MIR483 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR483

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR483 Gene

Disorders for MIR483 Gene

Relevant External Links for MIR483

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR483

No disorders were found for MIR483 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR483 Gene

Publications for MIR483 Gene

  1. Identification of human fetal liver miRNAs by a novel method. (PMID: 15978578) Fu H … Zheng X (FEBS letters 2005) 1 3 60
  2. Profile of 6 microRNA in blood plasma distinguish early stage Alzheimer's disease patients from non-demented subjects. (PMID: 28179587) Nagaraj S … Wojda U (Oncotarget 2017) 3 60
  3. Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2. (PMID: 28139355) Wang H … Bai X (Molecular therapy : the journal of the American Society of Gene Therapy 2017) 3 60
  4. miR‑483‑5p promotes growth, invasion and self‑renewal of gastric cancer stem cells by Wnt/β‑catenin signaling. (PMID: 27511210) Wu K … Zhu J (Molecular medicine reports 2016) 3 60
  5. Serum microRNAs as novel biomarkers for primary sclerosing cholangitis and cholangiocarcinoma. (PMID: 26864161) Bernuzzi F … Invernizzi P (Clinical and experimental immunology 2016) 3 60

Products for MIR483 Gene

Sources for MIR483 Gene

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