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Aliases for MIR483 Gene

Subcategory (RNA class) for MIR483 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR483 Gene

  • MicroRNA 483 2 3 5
  • Hsa-Mir-483 3
  • Mir-483 3
  • MIRN483 3

External Ids for MIR483 Gene

Previous HGNC Symbols for MIR483 Gene

  • MIRN483

Previous GeneCards Identifiers for MIR483 Gene

  • GC11M002115
  • GC11M002117
  • GC11M002155
  • GC11M002136
  • GC11M002138
  • GC11M002139
  • GC11M002146
  • GC11M002148
  • GC11M002154
  • GC11M002157

Summaries for MIR483 Gene

Entrez Gene Summary for MIR483 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR483 Gene

MIR483 (MicroRNA 483) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR483 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR483

Additional gene information for MIR483 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR483 Gene

Genomics for MIR483 Gene

GeneHancer (GH) Regulatory Elements for MIR483 Gene

Promoters and enhancers for MIR483 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I002131 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 -1.3 -1317 8 ZSCAN4 ARID4B KLF17 DMAP1 ZNF48 RARA ZNF335 GLIS2 ZNF366 EGR2 GC11M002134 MIR483 IGF2 CARS GC11P002138 INS-IGF2
GH11I002095 Enhancer 1.1 Ensembl ENCODE 12.2 +37.4 37391 3.6 ELF3 FOXA2 MLX ARID4B DMAP1 THRB ZNF48 ZSCAN9 RARA SLC30A9 MIR483 IGF2-AS IGF2 GC11P002077 ENSG00000240801
GH11I002108 Enhancer 0.9 Ensembl ENCODE 12.6 +24.8 24754 1.5 ELF3 GATAD2A TFAP4 RNF2 SAP130 MAX ELF1 RAD21 KAT8 TEAD3 MIR483 IGF2-AS IGF2 TNNT3 TH ENSG00000240801 GC11P002077
GH11I002099 Enhancer 0.9 Ensembl ENCODE 12.6 +34.1 34073 1.6 CTCF ATF1 ZIC2 ATF2 RFX5 GABPA ZNF335 GLIS1 VEZF1 GABPB1 ENSG00000240801 MIR483 IGF2-AS IGF2 GC11P002077
GH11I002178 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 11.3 -44.9 -44892 0.5 PKNOX1 ZSCAN4 FOS IGF2 TH IGF2-AS MIR483 ENSG00000236710 ASCL2 SYT8 MIR4686 GC11M002206
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR483 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR483 Gene

Genomic Locations for MIR483 Gene
chr11:2,134,134-2,134,209
(GRCh38/hg38)
Size:
76 bases
Orientation:
Minus strand
chr11:2,155,364-2,155,439
(GRCh37/hg19)

Genomic View for MIR483 Gene

Genes around MIR483 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR483 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR483 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR483 Gene

ORGUL Member Location for MIR483 Gene

ORGUL Member Location for MIR483 gene

Proteins for MIR483 Gene

Post-translational modifications for MIR483 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR483 Gene

Domains & Families for MIR483 Gene

Gene Families for MIR483 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR483: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR483 Gene

Function for MIR483 Gene

Phenotypes From GWAS Catalog for MIR483 Gene

Gene Ontology (GO) - Molecular Function for MIR483 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21893058
genes like me logo Genes that share ontologies with MIR483: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR483 Gene

Localization for MIR483 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR483 Gene

Pathways & Interactions for MIR483 Gene

SuperPathways for MIR483 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR483: view

Pathways by source for MIR483 Gene

1 KEGG pathway for MIR483 Gene

Interacting Proteins for MIR483 Gene

Gene Ontology (GO) - Biological Process for MIR483 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 22223106
GO:0035278 miRNA mediated inhibition of translation IDA 21893058
GO:0045599 negative regulation of fat cell differentiation ISS --
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IMP 21893058
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP 21893058
genes like me logo Genes that share ontologies with MIR483: view

No data available for SIGNOR curated interactions for MIR483 Gene

Drugs & Compounds for MIR483 Gene

No Compound Related Data Available

Transcripts for MIR483 Gene

fRNAdb Secondary structures for MIR483 Gene

  • hsa-mir-483_MI0002467_Homo_sapiens_miR-483_stem-loop_hairpin

mRNA/cDNA for MIR483 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR483 Gene

No ASD Table

Relevant External Links for MIR483 Gene

GeneLoc Exon Structure for
MIR483
ECgene alternative splicing isoforms for
MIR483

Expression for MIR483 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR483 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR483 Gene:

MIR483
genes like me logo Genes that share expression patterns with MIR483: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR483 Gene

Orthologs for MIR483 Gene

Evolution for MIR483 Gene

ENSEMBL:
Gene Tree for MIR483 (if available)
TreeFam:
Gene Tree for MIR483 (if available)

No data available for Orthologs for MIR483 Gene

Paralogs for MIR483 Gene

No data available for Paralogs for MIR483 Gene

Variants for MIR483 Gene

Sequence variations from dbSNP and Humsavar for MIR483 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1064794050 pathogenic, not provided, Russell-Silver syndrome 2,135,446(-) G/C upstream_transcript_variant
rs869320620 pathogenic, Growth restriction, severe, with distinctive facies 2,135,501(-) G/A/T upstream_transcript_variant
rs553443857 pathogenic, not provided 2,135,425(-) G/A/T upstream_transcript_variant
rs1057518115 likely-pathogenic, not provided 2,135,427(-) A/G upstream_transcript_variant
rs1001954193 -- 2,135,113(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR483 Gene

Variant ID Type Subtype PubMed ID
nsv467645 CNV gain 19166990
nsv553047 CNV gain 21841781
nsv553068 CNV loss 21841781
nsv825707 CNV gain 20364138
nsv951284 CNV deletion 24416366

Additional Variant Information for MIR483 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR483

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR483 Gene

Disorders for MIR483 Gene

Additional Disease Information for MIR483

No disorders were found for MIR483 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR483 Gene

Publications for MIR483 Gene

  1. Identification of human fetal liver miRNAs by a novel method. (PMID: 15978578) Fu H … Zheng X (FEBS letters 2005) 1 3 58
  2. miR-483 targets SMAD4 to suppress chondrogenic differentiation of human mesenchymal stem cells. (PMID: 28244607) Anderson BA … McAlinden A (Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2017) 3 58
  3. Profile of 6 microRNA in blood plasma distinguish early stage Alzheimer's disease patients from non-demented subjects. (PMID: 28179587) Nagaraj S … Wojda U (Oncotarget 2017) 3 58
  4. Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2. (PMID: 28139355) Wang H … Bai X (Molecular therapy : the journal of the American Society of Gene Therapy 2017) 3 58
  5. Downregulation of microRNA-483-5p Promotes Cell Proliferation and Invasion by Targeting GFRA4 in Hirschsprung's Disease. (PMID: 29090971) Wang G … Wu X (DNA and cell biology 2017) 3 58

Products for MIR483 Gene

Sources for MIR483 Gene

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