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Aliases for MIR4800 Gene

Subcategory (RNA class) for MIR4800 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4800 Gene

  • MicroRNA 4800 2 3
  • MXD4 4 5
  • Max-Interacting Transcriptional Repressor MAD4 4
  • Class C Basic Helix-Loop-Helix Protein 12 4
  • MAX Dimerization Protein 4 5
  • Max-Associated Protein 4 4
  • Max Dimerizer 4 4
  • Hsa-Mir-4800 3
  • Mir-4800 3
  • BHLHC12 4
  • MAD4 4

External Ids for MIR4800 Gene

Previous GeneCards Identifiers for MIR4800 Gene

  • GC04U901508
  • GC04M002253

Summaries for MIR4800 Gene

Entrez Gene Summary for MIR4800 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4800 Gene

MIR4800 (MicroRNA 4800) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is MXI1.

UniProtKB/Swiss-Prot for MIR4800 Gene

  • Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5-CAC[GA]TG-3. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4800 Gene

Genomics for MIR4800 Gene

Regulatory Elements for MIR4800 Gene

Enhancers for MIR4800 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR4800 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4800 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR4800 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4800 Gene

Chromosome:
4
Start:
2,247,432 bp from pter
End:
2,262,294 bp from pter
Size:
14,863 bases
Orientation:
Minus strand

Genomic View for MIR4800 Gene

Genes around MIR4800 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4800 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4800 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4800 Gene

ORGUL Member Location for MIR4800 Gene

ORGUL Member Location for MIR4800 gene

Proteins for MIR4800 Gene

  • Protein details for MIR4800 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14582-MAD4_HUMAN
    Recommended name:
    Max dimerization protein 4
    Protein Accession:
    Q14582
    Secondary Accessions:
    • A2A335
    • Q5TZX4

    Protein attributes for MIR4800 Gene

    Size:
    209 amino acids
    Molecular mass:
    23528 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17 (By similarity).
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17 (By similarity).

neXtProt entry for MIR4800 Gene

Post-translational modifications for MIR4800 Gene

  • Ubiquitination at Lys 77, Lys 96, and Lys 116
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR4800 Gene

No data available for DME Specific Peptides for MIR4800 Gene

Domains & Families for MIR4800 Gene

Gene Families for MIR4800 Gene

Protein Domains for MIR4800 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q14582

UniProtKB/Swiss-Prot:

MAD4_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with MIR4800: view

No data available for Suggested Antigen Peptide Sequences for MIR4800 Gene

Function for MIR4800 Gene

Molecular function for MIR4800 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5-CAC[GA]TG-3. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).

Gene Ontology (GO) - Molecular Function for MIR4800 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity TAS --
GO:0005515 protein binding IPI --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with MIR4800: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4800 Gene

Localization for MIR4800 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4800 Gene

Gene Ontology (GO) - Cellular Components for MIR4800 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MIR4800: view

No data available for Subcellular locations from COMPARTMENTS for MIR4800 Gene

Pathways & Interactions for MIR4800 Gene

SuperPathways for MIR4800 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4800 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0008285 negative regulation of cell proliferation TAS --
genes like me logo Genes that share ontologies with MIR4800: view

No data available for Pathways by source and SIGNOR curated interactions for MIR4800 Gene

Drugs & Compounds for MIR4800 Gene

No Compound Related Data Available

Transcripts for MIR4800 Gene

mRNA/cDNA for MIR4800 Gene

(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4800 Gene

No ASD Table

Relevant External Links for MIR4800 Gene

GeneLoc Exon Structure for
MIR4800
ECgene alternative splicing isoforms for
MIR4800

Expression for MIR4800 Gene

mRNA expression in normal human tissues for MIR4800 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4800 Gene:

MIR4800
genes like me logo Genes that share expression patterns with MIR4800: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4800 Gene

Orthologs for MIR4800 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR4800 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MXD4 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MXD4 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MXD4 35
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mxd4 35
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MXD4 35
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves MXD4 35
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MXD4 35
  • 74 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii MXD4 35
  • 67 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mdl-1 35
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2549 35
  • 36 (a)
OneToMany
Species where no ortholog for MIR4800 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR4800 Gene

ENSEMBL:
Gene Tree for MIR4800 (if available)
TreeFam:
Gene Tree for MIR4800 (if available)

Paralogs for MIR4800 Gene

Paralogs for MIR4800 Gene

genes like me logo Genes that share paralogs with MIR4800: view

Variants for MIR4800 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4800 Gene

Variant ID Type Subtype PubMed ID
dgv312n21 CNV loss 19592680
dgv8910n54 CNV loss 21841781
esv2726835 CNV deletion 23290073
nsv1009347 CNV gain 25217958
nsv508990 CNV insertion 20534489
nsv527189 CNV loss 19592680
nsv593375 CNV loss 21841781
nsv593376 CNV loss 21841781
nsv593377 CNV loss 21841781
nsv829838 CNV loss 17160897

Relevant External Links for MIR4800 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4800

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR4800 Gene

Disorders for MIR4800 Gene

Relevant External Links for MIR4800

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4800

No disorders were found for MIR4800 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4800 Gene

Publications for MIR4800 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 65
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 65
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 65
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65

Products for MIR4800 Gene

Sources for MIR4800 Gene

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