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Aliases for MIR4793 Gene

Subcategory (RNA class) for MIR4793 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4793 Gene

  • MicroRNA 4793 2 3
  • CELSR3 4 5
  • Multiple Epidermal Growth Factor-Like Domains Protein 2 4
  • Cadherin EGF LAG Seven-Pass G-Type Receptor 3 5
  • Epidermal Growth Factor-Like Protein 1 4
  • Multiple EGF-Like Domains Protein 2 4
  • Cadherin Family Member 11 4
  • Flamingo Homolog 1 4
  • EGF-Like Protein 1 4
  • Hsa-Mir-4793 3
  • KIAA0812 4
  • CDHF11 4
  • HFMI1 4
  • EGFL1 4
  • MEGF2 4
  • FMI1 4

External Ids for MIR4793 Gene

Previous GeneCards Identifiers for MIR4793 Gene

  • GC03U901784

Summaries for MIR4793 Gene

Entrez Gene Summary for MIR4793 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4793 Gene

MIR4793 (MicroRNA 4793) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are GPCRs, Other. An important paralog of this gene is CELSR2.

UniProtKB/Swiss-Prot for MIR4793 Gene

  • Receptor that may have an important role in cell/cell signaling during nervous system formation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4793 Gene

Genomics for MIR4793 Gene

Regulatory Elements for MIR4793 Gene

Enhancers for MIR4793 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F048682 1 ENCODE 13 -22.7 -22695 5.8 HDGF ATF1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ZNF121 WDR6 AMT NCKIPSD CELSR3 CELSR3-AS1 MIR4793 ARIH2 LOC105377080 ENSG00000223343 P4HTM
GH03F048661 0.2 ENCODE 0.8 -0.7 -651 3.1 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 WDR6 LAMB2 DAG1 CCDC71 IMPDH2 CELSR3 CELSR3-AS1 MIR4793
GH03F048662 0.2 ENCODE 0.8 +1.1 1063 0.2 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF143 ZNF207 PAF1 ENSG00000223343 NICN1 CELSR3 MIR4793 PIR43914
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4793 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4793 Gene

Chromosome:
3
Start:
48,636,469 bp from pter
End:
48,662,915 bp from pter
Size:
26,447 bases
Orientation:
Minus strand

Genomic View for MIR4793 Gene

Genes around MIR4793 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4793 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4793 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4793 Gene

Proteins for MIR4793 Gene

  • Protein details for MIR4793 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYQ7-CELR3_HUMAN
    Recommended name:
    Cadherin EGF LAG seven-pass G-type receptor 3
    Protein Accession:
    Q9NYQ7
    Secondary Accessions:
    • O75092

    Protein attributes for MIR4793 Gene

    Size:
    3312 amino acids
    Molecular mass:
    358185 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MIR4793 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR4793 Gene

Post-translational modifications for MIR4793 Gene

  • Ubiquitination at Lys 2143, Lys 2477, and Lys 2790
  • Glycosylation at Asn 632, Asn 847, Asn 1182, Asn 1222, Asn 1317, Asn 1327, Asn 1649, Asn 1713, Asn 1770, Asn 2053, Asn 2177, Asn 2196, Asn 2386, Asn 2474, and Asn 2506
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR4793 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MIR4793 Gene

Domains & Families for MIR4793 Gene

Gene Families for MIR4793 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYQ7

UniProtKB/Swiss-Prot:

CELR3_HUMAN :
  • Contains 9 cadherin domains.
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Domain:
  • Contains 9 cadherin domains.
  • Contains 8 EGF-like domains.
  • Contains 1 GPS domain.
  • Contains 1 laminin EGF-like domain.
  • Contains 2 laminin G-like domains.
Family:
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
genes like me logo Genes that share domains with MIR4793: view

No data available for Suggested Antigen Peptide Sequences for MIR4793 Gene

Function for MIR4793 Gene

Molecular function for MIR4793 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may have an important role in cell/cell signaling during nervous system formation.

Gene Ontology (GO) - Molecular Function for MIR4793 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity TAS --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with MIR4793: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4793 Gene

Localization for MIR4793 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4793 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MIR4793 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS --
genes like me logo Genes that share ontologies with MIR4793: view

No data available for Subcellular locations from COMPARTMENTS for MIR4793 Gene

Pathways & Interactions for MIR4793 Gene

SuperPathways for MIR4793 Gene

SuperPathway Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with MIR4793: view

Pathways by source for MIR4793 Gene

1 BioSystems pathway for MIR4793 Gene

Gene Ontology (GO) - Biological Process for MIR4793 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation IEA --
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with MIR4793: view

No data available for SIGNOR curated interactions for MIR4793 Gene

Transcripts for MIR4793 Gene

mRNA/cDNA for MIR4793 Gene

(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4793 Gene

No ASD Table

Relevant External Links for MIR4793 Gene

GeneLoc Exon Structure for
MIR4793
ECgene alternative splicing isoforms for
MIR4793

Expression for MIR4793 Gene

mRNA expression in normal human tissues for MIR4793 Gene

mRNA differential expression in normal tissues according to GTEx for MIR4793 Gene

This gene is overexpressed in Brain - Cerebellum (x10.5), Brain - Cerebellar Hemisphere (x7.9), and Pituitary (x6.1).

NURSA nuclear receptor signaling pathways regulating expression of MIR4793 Gene:

MIR4793
genes like me logo Genes that share expression patterns with MIR4793: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4793 Gene

Orthologs for MIR4793 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR4793 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CELSR3 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CELSR3 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CELSR3 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Celsr3 35
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CELSR3 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CELSR3 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves CELSR3 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CELSR3 35
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii celsr3 35
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta stan 35
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fmi-1 35
  • 27 (a)
OneToMany
Species where no ortholog for MIR4793 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR4793 Gene

ENSEMBL:
Gene Tree for MIR4793 (if available)
TreeFam:
Gene Tree for MIR4793 (if available)

Paralogs for MIR4793 Gene

Paralogs for MIR4793 Gene

genes like me logo Genes that share paralogs with MIR4793: view

Variants for MIR4793 Gene

Sequence variations from dbSNP and Humsavar for MIR4793 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs149614835 Uncertain significance 48,645,117(+) ACCTG(C/T)ATGCG upstream-variant-2KB, reference, missense
rs111659820 -- 48,645,527(+) CCACG(A/C)ACATT upstream-variant-2KB, reference, synonymous-codon
rs112026509 -- 48,644,764(+) GGCTC(A/C/G)TGGAC upstream-variant-2KB, reference, synonymous-codon, missense
rs112310278 -- 48,645,954(+) GTGCC(A/T)GGAGT intron-variant, upstream-variant-2KB
rs112373464 -- 48,645,990(+) GGGTT(A/G)CACAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4793 Gene

Variant ID Type Subtype PubMed ID
nsv523981 CNV loss 19592680
nsv590246 CNV loss 21841781
nsv590247 CNV loss 21841781
nsv818138 CNV gain 17921354
nsv834685 CNV loss 17160897
nsv954485 CNV deletion 24416366

Relevant External Links for MIR4793 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4793

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4793 Gene

Disorders for MIR4793 Gene

Relevant External Links for MIR4793

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4793

No disorders were found for MIR4793 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4793 Gene

Publications for MIR4793 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  2. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 64
  5. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PMID: 10716726) Wu Q. … Maniatis T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 4 64

Products for MIR4793 Gene

Sources for MIR4793 Gene

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