Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR4785 Gene

Subcategory (RNA class) for MIR4785 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4785 Gene

  • MicroRNA 4785 2 3
  • RBMS1 4 5
  • RNA Binding Motif Single Stranded Interacting Protein 1 5
  • Suppressor Of CDC2 With RNA-Binding Motif 2 4
  • Single-Stranded DNA-Binding Protein MSSP-1 4
  • Hsa-Mir-4785 3
  • Mir-4785 3
  • C2orf12 4
  • MSSP1 4
  • MSSP 4
  • SCR2 4

External Ids for MIR4785 Gene

Previous GeneCards Identifiers for MIR4785 Gene

  • GC02U902434
  • GC02M161266
  • GC02M160408

Summaries for MIR4785 Gene

Entrez Gene Summary for MIR4785 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4785 Gene

MIR4785 (MicroRNA 4785) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is RBMS3.

UniProtKB/Swiss-Prot for MIR4785 Gene

  • Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5-[AT]CT[AT][AT]T-3. Probably has a role in DNA replication.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4785 Gene

Genomics for MIR4785 Gene

Regulatory Elements for MIR4785 Gene

Enhancers for MIR4785 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F160363 1.4 FANTOM5 Ensembl ENCODE 12.7 +120.4 120394 20.0 SIN3A FEZF1 YY1 GLIS2 ZNF143 ZNF263 ZNF202 SP3 REST TBX21 PLA2R1 ITGB6 MIR4785 RBMS1 GC02M160337 LOC100419108
GH02F160245 0.2 Ensembl 12.5 +248.1 248094 0.2 ITGB6 MIR4785 RBMS1 PIR61464 PLA2R1
GH02F160246 0.2 Ensembl 12.5 +247.3 247294 0.2 MAFG DPF2 ZNF384 JUND CEBPA NFE2L1 FOS NFE2 MAFK NFE2L2 ITGB6 MIR4785 RBMS1 PIR61464 PLA2R1
GH02F160523 0.2 Ensembl 12.3 -29.5 -29507 0.6 RBMS1 MIR4785 LOC105373718
GH02F160471 0.8 Ensembl ENCODE 12.2 +20.0 20017 4.0 PKNOX1 INSM2 FEZF1 ZNF2 ZNF366 FOS OVOL3 CEBPB ZEB2 TSHZ1 RBMS1 MIR4785 PLA2R1 ITGB6 LY75 LOC100419108
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4785 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4785 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000601200 1194 4001 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 KLF7 ZNF263

Genomic Location for MIR4785 Gene

Chromosome:
2
Start:
160,272,151 bp from pter
End:
160,493,794 bp from pter
Size:
221,644 bases
Orientation:
Minus strand

Genomic View for MIR4785 Gene

Genes around MIR4785 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4785 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4785 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4785 Gene

Proteins for MIR4785 Gene

  • Protein details for MIR4785 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29558-RBMS1_HUMAN
    Recommended name:
    RNA-binding motif, single-stranded-interacting protein 1
    Protein Accession:
    P29558
    Secondary Accessions:
    • Q14869
    • Q15433
    • Q53P46
    • Q53QX8
    • Q53RG6
    • Q8WV20

    Protein attributes for MIR4785 Gene

    Size:
    406 amino acids
    Molecular mass:
    44505 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX93095.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAA45923.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA45923.1; Type=Frameshift; Positions=319, 360; Evidence={ECO:0000305}; Sequence=CAA54628.1; Type=Erroneous translation; Note=Wrong coding sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MIR4785 Gene

    Alternative splice isoforms for MIR4785 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR4785 Gene

Post-translational modifications for MIR4785 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR4785 Gene

No data available for DME Specific Peptides for MIR4785 Gene

Domains & Families for MIR4785 Gene

Gene Families for MIR4785 Gene

Graphical View of Domain Structure for InterPro Entry

P29558

UniProtKB/Swiss-Prot:

RBMS1_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with MIR4785: view

No data available for Suggested Antigen Peptide Sequences for MIR4785 Gene

Function for MIR4785 Gene

Molecular function for MIR4785 Gene

UniProtKB/Swiss-Prot Function:
Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5-[AT]CT[AT][AT]T-3. Probably has a role in DNA replication.

Gene Ontology (GO) - Molecular Function for MIR4785 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003690 double-stranded DNA binding NAS --
GO:0003697 single-stranded DNA binding NAS --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with MIR4785: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4785 Gene

Localization for MIR4785 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4785 Gene

Gene Ontology (GO) - Cellular Components for MIR4785 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS --
genes like me logo Genes that share ontologies with MIR4785: view

No data available for Subcellular locations from COMPARTMENTS for MIR4785 Gene

Pathways & Interactions for MIR4785 Gene

SuperPathways for MIR4785 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4785 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication NAS --
GO:0006396 RNA processing TAS --
genes like me logo Genes that share ontologies with MIR4785: view

No data available for Pathways by source and SIGNOR curated interactions for MIR4785 Gene

Transcripts for MIR4785 Gene

mRNA/cDNA for MIR4785 Gene

(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4785 Gene

No ASD Table

Relevant External Links for MIR4785 Gene

GeneLoc Exon Structure for
MIR4785
ECgene alternative splicing isoforms for
MIR4785

Expression for MIR4785 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4785 Gene:

MIR4785

mRNA Expression by UniProt/SwissProt for MIR4785 Gene:

P29558-RBMS1_HUMAN
Tissue specificity: Highest amounts are found in placenta, lung and heart.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR4785 Gene

Orthologs for MIR4785 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR4785 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RBMS1 35
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RBMS1 35
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBMS1 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBMS1 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBMS1 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbms1 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBMS1 35
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBMS1 35
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii RBMS1 (1 of 2) 35
  • 70 (a)
OneToMany
rbms1a 35
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta shep 35
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sup-26 35
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAB1 35
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1122 35
  • 43 (a)
OneToMany
Species where no ortholog for MIR4785 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR4785 Gene

ENSEMBL:
Gene Tree for MIR4785 (if available)
TreeFam:
Gene Tree for MIR4785 (if available)

Paralogs for MIR4785 Gene

Pseudogenes.org Pseudogenes for MIR4785 Gene

genes like me logo Genes that share paralogs with MIR4785: view

Variants for MIR4785 Gene

Sequence variations from dbSNP and Humsavar for MIR4785 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs113052146 -- 160,407,347(+) TCCTG(A/G)GAAAC intron-variant, downstream-variant-500B
rs115603318 -- 160,409,352(+) ACTTG(C/T)CAGAC intron-variant, upstream-variant-2KB
rs12692596 -- 160,409,399(+) AGTAT(C/T)AAACA intron-variant, upstream-variant-2KB
rs13002343 -- 160,407,570(+) ggcgc(A/G)ggcgc intron-variant, downstream-variant-500B, utr-variant-5-prime
rs13002510 -- 160,407,587(+) GCCTC(G/T)CCGCG intron-variant, downstream-variant-500B, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR4785 Gene

Variant ID Type Subtype PubMed ID
nsv1143963 CNV deletion 24896259
nsv2998 CNV insertion 18451855

Relevant External Links for MIR4785 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4785

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4785 Gene

Disorders for MIR4785 Gene

Relevant External Links for MIR4785

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4785

No disorders were found for MIR4785 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4785 Gene

Publications for MIR4785 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64
  4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 4 64
  5. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64

Products for MIR4785 Gene

Sources for MIR4785 Gene

Content
Loading form....