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Aliases for MIR4784 Gene

Subcategory (RNA class) for MIR4784 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4784 Gene

  • MicroRNA 4784 2 3
  • MZT2A 4 5
  • Mitotic-Spindle Organizing Protein Associated With A Ring Of Gamma-Tubulin 2A 4
  • Mitotic Spindle Organizing Protein 2A 5
  • Hsa-Mir-4784 3
  • MOZART2A 4
  • FAM128A 4

External Ids for MIR4784 Gene

Previous GeneCards Identifiers for MIR4784 Gene

  • GC02U902417
  • GC02M132300
  • GC02M132313
  • GC02M132334

Summaries for MIR4784 Gene

Entrez Gene Summary for MIR4784 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4784 Gene

MIR4784 (MicroRNA 4784) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is MZT2B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4784 Gene

Genomics for MIR4784 Gene

Regulatory Elements for MIR4784 Gene

Enhancers for MIR4784 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR4784 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4784 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR4784 Gene

Chromosome:
2
Start:
131,464,900 bp from pter
End:
131,492,743 bp from pter
Size:
27,844 bases
Orientation:
Minus strand

Genomic View for MIR4784 Gene

Genes around MIR4784 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4784 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4784 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4784 Gene

ORGUL Member Location for MIR4784 Gene

ORGUL Member Location for MIR4784 gene

Proteins for MIR4784 Gene

  • Protein details for MIR4784 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P582-MZT2A_HUMAN
    Recommended name:
    Mitotic-spindle organizing protein 2A
    Protein Accession:
    Q6P582
    Secondary Accessions:
    • Q3SWV8
    • Q8WVB2

    Protein attributes for MIR4784 Gene

    Size:
    158 amino acids
    Molecular mass:
    16221 Da
    Quaternary structure:
    • Part of the gamma-tubulin complex.
    • Part of the gamma-tubulin complex.
    SequenceCaution:
    • Sequence=AAX93252.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MIR4784 Gene

Post-translational modifications for MIR4784 Gene

  • Ubiquitination at Lys 110
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR4784 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MIR4784 Gene

Domains & Families for MIR4784 Gene

Gene Families for MIR4784 Gene

Protein Domains for MIR4784 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6P582

UniProtKB/Swiss-Prot:

MZT2A_HUMAN :
  • Belongs to the MOZART2 family.
Family:
  • Belongs to the MOZART2 family.
genes like me logo Genes that share domains with MIR4784: view

No data available for Suggested Antigen Peptide Sequences for MIR4784 Gene

Function for MIR4784 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4784 Gene

Localization for MIR4784 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4784 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.

Gene Ontology (GO) - Cellular Components for MIR4784 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005819 spindle ISS --
GO:0008274 gamma-tubulin ring complex ISS --
genes like me logo Genes that share ontologies with MIR4784: view

No data available for Subcellular locations from COMPARTMENTS for MIR4784 Gene

Pathways & Interactions for MIR4784 Gene

SuperPathways for MIR4784 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4784 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4784 Gene

Drugs & Compounds for MIR4784 Gene

No Compound Related Data Available

Transcripts for MIR4784 Gene

mRNA/cDNA for MIR4784 Gene

(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4784 Gene

No ASD Table

Relevant External Links for MIR4784 Gene

GeneLoc Exon Structure for
MIR4784
ECgene alternative splicing isoforms for
MIR4784

Expression for MIR4784 Gene

mRNA expression in normal human tissues for MIR4784 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4784 Gene:

MIR4784
genes like me logo Genes that share expression patterns with MIR4784: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4784 Gene

Orthologs for MIR4784 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR4784 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 91 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 67 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mzt2 35
  • 68 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia MZT2B 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MZT2 35
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 42 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii mzt2b 35
  • 35 (a)
OneToMany
Species where no ortholog for MIR4784 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR4784 Gene

ENSEMBL:
Gene Tree for MIR4784 (if available)
TreeFam:
Gene Tree for MIR4784 (if available)

Paralogs for MIR4784 Gene

Paralogs for MIR4784 Gene

Pseudogenes.org Pseudogenes for MIR4784 Gene

genes like me logo Genes that share paralogs with MIR4784: view

Variants for MIR4784 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4784 Gene

Variant ID Type Subtype PubMed ID
dgv4075n100 CNV gain 25217958
dgv4077n100 CNV gain 25217958
dgv4079n100 CNV loss 25217958
dgv4080n100 CNV gain 25217958
dgv476n27 CNV loss 19166990
esv2670824 CNV deletion 23128226
esv2759092 CNV gain+loss 17122850
esv2760576 CNV gain+loss 21179565
esv34412 CNV gain 17911159
esv34704 CNV gain 17911159
esv3575300 CNV gain 25503493
esv3584079 CNV loss 25503493
esv3592483 CNV loss 21293372
esv3592484 CNV gain 21293372
esv3893359 CNV gain+loss 25118596
nsv1002963 CNV gain 25217958
nsv1006738 CNV gain 25217958
nsv1008539 CNV gain 25217958
nsv1014682 CNV loss 25217958
nsv428404 CNV loss 18775914
nsv459396 CNV gain 19166990
nsv470486 CNV loss 18288195
nsv524021 CNV loss 19592680
nsv583140 CNV gain 21841781
nsv583143 CNV gain+loss 21841781
nsv583145 CNV loss 21841781
nsv7327 OTHER inversion 18451855
nsv834376 CNV gain 17160897
nsv979124 CNV duplication 23825009
nsv997248 CNV loss 25217958

Relevant External Links for MIR4784 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4784

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR4784 Gene

Disorders for MIR4784 Gene

Relevant External Links for MIR4784

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4784

No disorders were found for MIR4784 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4784 Gene

Publications for MIR4784 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 65
  2. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 4 65
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 65
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65

Products for MIR4784 Gene

Sources for MIR4784 Gene

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