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Aliases for MIR4781 Gene

Subcategory (RNA class) for MIR4781 Gene


Quality Score for this RNA gene is


Aliases for MIR4781 Gene

  • MicroRNA 4781 2 3
  • TCEANC2 4 5
  • Transcription Elongation Factor A N-Terminal And Central Domain Containing 2 5
  • Hsa-Mir-4781 3
  • Mir-4781 3
  • C1orf83 4

External Ids for MIR4781 Gene

Previous GeneCards Identifiers for MIR4781 Gene

  • GC01U903261
  • GC01P054524

Summaries for MIR4781 Gene

Entrez Gene Summary for MIR4781 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4781 Gene

MIR4781 (MicroRNA 4781) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4781 Gene

Genomics for MIR4781 Gene

Regulatory Elements for MIR4781 Gene

Enhancers for MIR4781 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F054484 1.8 FANTOM5 Ensembl ENCODE 10.2 +434.2 434216 6.8 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A ZNF2 YY1 CBX5 ZNF143 ZNF207 TCEANC2 SSBP3 HSPB11 ENSG00000237453 TTC22 TMEM59 MIR4781 LOC105378735 ENSG00000232245
GH01F054271 1.6 FANTOM5 Ensembl ENCODE 10 +223.0 222955 10.6 HDGF ATF1 PKNOX1 FEZF1 ZNF2 YY1 ZNF121 GLIS2 CBX5 ZNF143 SSBP3-AS1 SSBP3 TMEM59 HSPB11 MIR4781 TCEANC2 ENSG00000237453 TTC22 ENSG00000225632 GC01P054263
GH01F054309 1.5 FANTOM5 Ensembl ENCODE 10.2 +258.7 258747 6.3 CBX3 PKNOX1 KLF17 FEZF1 RAD21 RARA ZNF121 GLIS2 ZNF143 EGR2 HSPB11 ENSG00000225632 SSBP3 SSBP3-AS1 CDCP2 MIR4781 TCEANC2 TMEM59 TTC22 ENSG00000237453
GH01F054403 1.5 FANTOM5 ENCODE 9.8 +353.3 353325 7.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 ENSG00000225632 SSBP3-AS1 MIR4781 TCEANC2 TMEM59 ENSG00000230728 SSBP3 PIR46432 GC01M054384
GH01F054081 1.2 Ensembl ENCODE 11.8 +28.2 28162 0.3 CBX3 ARID4B RAD21 RARA ZNF121 ZNF766 ZNF143 MIXL1 EGR2 THAP11 TCEANC2 MIR4781 TMEM59 CDCP2 LDLRAD1 HSPB11 LRRC42 SSBP3-AS1 GC01P054077 LOC100507586
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4781 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4781 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR4781 Gene

54,053,587 bp from pter
54,112,519 bp from pter
58,933 bases
Plus strand

Genomic View for MIR4781 Gene

Genes around MIR4781 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4781 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4781 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4781 Gene

Proteins for MIR4781 Gene

  • Protein details for MIR4781 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription elongation factor A N-terminal and central domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q5T702
    • Q8N8N2

    Protein attributes for MIR4781 Gene

    208 amino acids
    Molecular mass:
    24150 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI22668.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR4781 Gene


neXtProt entry for MIR4781 Gene

Post-translational modifications for MIR4781 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR4781 Gene

No data available for DME Specific Peptides for MIR4781 Gene

Domains & Families for MIR4781 Gene

Gene Families for MIR4781 Gene

Protein Domains for MIR4781 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 TFIIS central domain.
  • Belongs to the TCEANC2 family.
  • Contains 1 TFIIS central domain.
  • Contains 1 TFIIS N-terminal domain.
  • Belongs to the TCEANC2 family.
genes like me logo Genes that share domains with MIR4781: view

No data available for Suggested Antigen Peptide Sequences for MIR4781 Gene

Function for MIR4781 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4781 Gene

Localization for MIR4781 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4781 Gene

Gene Ontology (GO) - Cellular Components for MIR4781 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MIR4781: view

No data available for Subcellular locations from COMPARTMENTS for MIR4781 Gene

Pathways & Interactions for MIR4781 Gene

SuperPathways for MIR4781 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4781 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MIR4781: view

No data available for Pathways by source and SIGNOR curated interactions for MIR4781 Gene

Transcripts for MIR4781 Gene

mRNA/cDNA for MIR4781 Gene

(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4781 Gene

No ASD Table

Relevant External Links for MIR4781 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4781 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4781 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4781 Gene

Orthologs for MIR4781 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR4781 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Tceanc2 35
  • 91 (a)
(Bos Taurus)
Mammalia TCEANC2 35
  • 90 (a)
(Canis familiaris)
Mammalia TCEANC2 35
  • 90 (a)
(Pan troglodytes)
Mammalia TCEANC2 35
  • 87 (a)
(Monodelphis domestica)
Mammalia TCEANC2 35
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia TCEANC2 35
  • 63 (a)
(Gallus gallus)
Aves TCEANC2 35
  • 69 (a)
(Anolis carolinensis)
Reptilia TCEANC2 35
  • 72 (a)
(Danio rerio)
Actinopterygii tceanc2 35
  • 65 (a)
Species where no ortholog for MIR4781 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR4781 Gene

Gene Tree for MIR4781 (if available)
Gene Tree for MIR4781 (if available)

Paralogs for MIR4781 Gene

No data available for Paralogs for MIR4781 Gene

Variants for MIR4781 Gene

Sequence variations from dbSNP and Humsavar for MIR4781 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111706051 -- 54,052,894(+) AGCGA(C/T)TGAAG intron-variant, upstream-variant-2KB
rs111734031 -- 54,054,222(+) TCGGA(A/G)GATCT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs11206279 -- 54,053,485(+) TCTCC(A/G)TAGGC upstream-variant-2KB, utr-variant-5-prime
rs112868756 -- 54,053,648(+) ACTAC(C/T)GCCCT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs113288810 -- 54,054,361(+) AGAAT(C/T)TGCCC intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4781 Gene

Variant ID Type Subtype PubMed ID
nsv1011262 CNV gain 25217958

Relevant External Links for MIR4781 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4781 Gene

Disorders for MIR4781 Gene

Relevant External Links for MIR4781

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR4781 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4781 Gene

Publications for MIR4781 Gene

  1. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4781 Gene

Sources for MIR4781 Gene

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