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Aliases for MIR4775 Gene

Subcategory (RNA class) for MIR4775 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4775 Gene

  • MicroRNA 4775 2 3
  • CCNYL1 4 5
  • Cyclin Y Like 1 5
  • Hsa-Mir-4775 3

External Ids for MIR4775 Gene

Previous GeneCards Identifiers for MIR4775 Gene

  • GC02U902422
  • GC02P208621

Summaries for MIR4775 Gene

Entrez Gene Summary for MIR4775 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4775 Gene

MIR4775 (MicroRNA 4775) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is CCNY.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4775 Gene

Genomics for MIR4775 Gene

Regulatory Elements for MIR4775 Gene

Enhancers for MIR4775 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F207691 0.5 Ensembl 12 -20.4 -20440 0.2 ZGPAT CEBPA CEBPB CEBPG CCNYL1 MIR4775 METTL21A FZD5 PLEKHM3 ENSG00000200764
GH02F207692 0.6 Ensembl 12 -20.0 -20040 0.2 ZGPAT CCNYL1 MIR4775 METTL21A FZD5 PLEKHM3 ENSG00000200764
GH02F207676 0.6 Ensembl ENCODE 11.5 -34.5 -34478 1.5 HDAC1 ATF1 CBX3 TBL1XR1 ARNT CHAMP1 ZNF766 GATA2 FOS CREM CCNYL1 FASTKD2 MIR4775 METTL21A FZD5 LINC01857 GC02M207673 GC02M207681 RNU6-664P
GH02F207674 0.5 ENCODE 11.5 -36.7 -36654 1.4 ZNF140 POU5F1 ZBTB33 RAD21 MIR4775 CCNYL1 METTL21A FZD5 LINC01857 GC02M207673 GC02M207681 RNU6-664P
GH02F207737 0.7 FANTOM5 11.1 +26.3 26345 0.4 MTA2 ZNF157 CBFB JUNB TBX21 GABPA METTL21A ENSG00000200764 CCNYL1 MIR4775 PPP1R14BP2 RNU6-664P FZD5 PLEKHM3 ENSG00000272851
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4775 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4775 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000606343 561 3400 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 FOS SP3

Genomic Location for MIR4775 Gene

Chromosome:
2
Start:
207,711,540 bp from pter
End:
207,761,839 bp from pter
Size:
50,300 bases
Orientation:
Plus strand

Genomic View for MIR4775 Gene

Genes around MIR4775 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4775 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4775 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4775 Gene

Proteins for MIR4775 Gene

  • Protein details for MIR4775 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7R7-CCYL1_HUMAN
    Recommended name:
    Cyclin-Y-like protein 1
    Protein Accession:
    Q8N7R7
    Secondary Accessions:
    • Q6NX60

    Protein attributes for MIR4775 Gene

    Size:
    359 amino acids
    Molecular mass:
    40705 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH67253.1; Type=Frameshift; Positions=47; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR4775 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR4775 Gene

Post-translational modifications for MIR4775 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR4775 Gene

No data available for DME Specific Peptides for MIR4775 Gene

Domains & Families for MIR4775 Gene

Gene Families for MIR4775 Gene

Protein Domains for MIR4775 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N7R7

UniProtKB/Swiss-Prot:

CCYL1_HUMAN :
  • Contains 1 cyclin N-terminal domain.
  • Belongs to the cyclin family. Cyclin Y subfamily.
Domain:
  • Contains 1 cyclin N-terminal domain.
Family:
  • Belongs to the cyclin family. Cyclin Y subfamily.
genes like me logo Genes that share domains with MIR4775: view

No data available for Suggested Antigen Peptide Sequences for MIR4775 Gene

Function for MIR4775 Gene

Gene Ontology (GO) - Molecular Function for MIR4775 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with MIR4775: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4775 Gene

Localization for MIR4775 Gene

Gene Ontology (GO) - Cellular Components for MIR4775 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MIR4775: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for MIR4775 Gene

Pathways & Interactions for MIR4775 Gene

SuperPathways for MIR4775 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4775 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation IEA --
GO:0007283 spermatogenesis IEA --
GO:0030317 flagellated sperm motility IEA --
GO:0045859 regulation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with MIR4775: view

No data available for Pathways by source and SIGNOR curated interactions for MIR4775 Gene

Transcripts for MIR4775 Gene

mRNA/cDNA for MIR4775 Gene

(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4775 Gene

No ASD Table

Relevant External Links for MIR4775 Gene

GeneLoc Exon Structure for
MIR4775
ECgene alternative splicing isoforms for
MIR4775

Expression for MIR4775 Gene

mRNA expression in normal human tissues for MIR4775 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4775 Gene:

MIR4775
genes like me logo Genes that share expression patterns with MIR4775: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4775 Gene

Orthologs for MIR4775 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR4775 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNYL1 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnyl1 35
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCNYL1 35
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNYL1 35
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNYL1 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNYL1 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNYL1 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNYL1 35
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ccnyl1 35
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CycY 35
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyy-1 35
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5028 35
  • 50 (a)
OneToMany
Species where no ortholog for MIR4775 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR4775 Gene

ENSEMBL:
Gene Tree for MIR4775 (if available)
TreeFam:
Gene Tree for MIR4775 (if available)

Paralogs for MIR4775 Gene

Paralogs for MIR4775 Gene

genes like me logo Genes that share paralogs with MIR4775: view

Variants for MIR4775 Gene

Sequence variations from dbSNP and Humsavar for MIR4775 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10640659 -- 207,752,914(+) ATGCC(-/TGT)TGTAA intron-variant, upstream-variant-2KB
rs112680679 -- 207,753,502(+) TCCAC(-/AT)GTGTG intron-variant, upstream-variant-2KB
rs1127039 -- 207,754,926(+) cgcct(A/C)tagtc nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1127041 -- 207,754,951(+) ggctg(A/G)ggctg nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1127042 -- 207,755,018(+) ggaat(A/G)gctac nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR4775 Gene

Variant ID Type Subtype PubMed ID
nsv3133 CNV insertion 18451855
nsv963769 CNV duplication 23825009

Relevant External Links for MIR4775 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4775

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4775 Gene

Disorders for MIR4775 Gene

Relevant External Links for MIR4775

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4775

No disorders were found for MIR4775 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4775 Gene

Publications for MIR4775 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 4 64

Products for MIR4775 Gene

Sources for MIR4775 Gene

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