Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR4774 Gene

Subcategory (RNA class) for MIR4774 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4774 Gene

  • MicroRNA 4774 2 3 5
  • Hsa-Mir-4774 3

External Ids for MIR4774 Gene

Previous GeneCards Identifiers for MIR4774 Gene

  • GC02U902454
  • GC02P169442

Summaries for MIR4774 Gene

Entrez Gene Summary for MIR4774 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4774 Gene

MIR4774 (MicroRNA 4774) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4774 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4774 Gene

Genomics for MIR4774 Gene

GeneHancer (GH) Regulatory Elements for MIR4774 Gene

Promoters and enhancers for MIR4774 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I168582 Enhancer 1 Ensembl ENCODE dbSUPER 550.8 +1.2 1166 2.6 PKNOX1 MAFG ZEB1 ZSCAN21 JUND ZNF692 SCRT2 NFE2 PRDM10 RUNX3 MIR4774 RNU6-766P CERS6 GC02M168607
GH02I168564 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.4 -17.6 -17642 1.4 POLR2A CEBPA CEBPB CEBPG MNT FOS ZBTB20 GC02M168537 MIR4774 CERS6
GH02I168594 Enhancer 0.7 ENCODE dbSUPER 0.4 +12.1 12051 0.8 HLF EBF1 BATF RUNX3 SPI1 STK39 GC02M168607 RNU6-766P MIR4774 CERS6
GH02I168550 Enhancer 0.9 Ensembl ENCODE 0.3 -31.4 -31368 2.6 USF1 MAX BACH1 SIN3A EBF1 IRF4 ETS1 POLR2A ATF7 BCLAF1 CERS6 GC02M168537 MIR4774
GH02I168545 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.3 -37.1 -37101 1.4 CTBP1 CREB1 FOS WT1 GC02M168537 CERS6 MIR4774
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4774 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4774 Gene

Genomic Locations for MIR4774 Gene
chr2:168,582,943-168,583,018
(GRCh38/hg38)
Size:
76 bases
Orientation:
Plus strand
chr2:169,439,453-169,439,528
(GRCh37/hg19)

Genomic View for MIR4774 Gene

Genes around MIR4774 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4774 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4774 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4774 Gene

Proteins for MIR4774 Gene

Post-translational modifications for MIR4774 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4774 Gene

Domains & Families for MIR4774 Gene

Gene Families for MIR4774 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4774: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4774 Gene

Function for MIR4774 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4774 Gene

Localization for MIR4774 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4774 Gene

Pathways & Interactions for MIR4774 Gene

SuperPathways for MIR4774 Gene

No Data Available

Interacting Proteins for MIR4774 Gene

Gene Ontology (GO) - Biological Process for MIR4774 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4774 Gene

Drugs & Compounds for MIR4774 Gene

No Compound Related Data Available

Transcripts for MIR4774 Gene

mRNA/cDNA for MIR4774 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4774 Gene

No ASD Table

Relevant External Links for MIR4774 Gene

GeneLoc Exon Structure for
MIR4774
ECgene alternative splicing isoforms for
MIR4774

Expression for MIR4774 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4774 Gene:

MIR4774
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4774 Gene

Orthologs for MIR4774 Gene

Evolution for MIR4774 Gene

ENSEMBL:
Gene Tree for MIR4774 (if available)
TreeFam:
Gene Tree for MIR4774 (if available)

No data available for Orthologs for MIR4774 Gene

Paralogs for MIR4774 Gene

No data available for Paralogs for MIR4774 Gene

Variants for MIR4774 Gene

Sequence variations from dbSNP and Humsavar for MIR4774 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000542358 -- 168,581,453(+) A/G upstream_transcript_variant
rs1001011422 -- 168,581,650(+) T/A upstream_transcript_variant
rs1001348309 -- 168,582,874(+) G/A upstream_transcript_variant
rs1001497973 -- 168,581,844(+) T/C upstream_transcript_variant
rs1001648225 -- 168,581,536(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4774 Gene

Variant ID Type Subtype PubMed ID
dgv64n68 CNV gain 17160897
nsv428405 CNV loss 18775914

Additional Variant Information for MIR4774 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4774

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4774 Gene

Disorders for MIR4774 Gene

Additional Disease Information for MIR4774

No disorders were found for MIR4774 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4774 Gene

Publications for MIR4774 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 58
  2. Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia. (PMID: 21606961) Schotte D … den Boer ML (Leukemia 2011) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4774 Gene

Sources for MIR4774 Gene

Content
Loading form....