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Aliases for MIR4761 Gene

Subcategory (RNA class) for MIR4761 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4761 Gene

  • MicroRNA 4761 2 3 5
  • Hsa-Mir-4761 3

External Ids for MIR4761 Gene

Previous GeneCards Identifiers for MIR4761 Gene

  • GC22U900800
  • GC22P019976
  • GC22P019984
  • GC22P019992

Summaries for MIR4761 Gene

Entrez Gene Summary for MIR4761 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4761 Gene

MIR4761 (MicroRNA 4761) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Cytochrome P450 - arranged by substrate type and Neurotransmitter Clearance In The Synaptic Cleft.

Additional gene information for MIR4761 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4761 Gene

Genomics for MIR4761 Gene

GeneHancer (GH) Regulatory Elements for MIR4761 Gene

Promoters and enhancers for MIR4761 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I019958 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.8 -2.3 -2278 6.4 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 COMT GC22M019961 LINC01311 LOC100420177 UFD1 RPL7AP70 KLHL22 ENSG00000273343 ZNF74 MED15
GH22I019965 Enhancer 1 ENCODE dbSUPER 0.8 +3.5 3545 4.3 HDGF HNRNPUL1 ATF1 RB1 NFIB ARNT RAD21 YY1 ZNF121 POLR2B ARVCF MED15 RPL7AP70 DGCR11 UFD1 COMT MIR4761 GC22P019980
GH22I019974 Enhancer 1.4 Ensembl ENCODE dbSUPER 0.4 +11.4 11448 2.2 HDGF PKNOX1 ATF1 ARNT SIN3A TCF12 GLIS2 ARID2 ZNF143 FOS ARVCF ABHD17AP4 UFD1 RPL7AP70 COMT GC22P019980 MIR4761
GH22I019970 Enhancer 1.2 ENCODE dbSUPER 0.4 +7.5 7487 2.4 HDGF HNRNPUL1 FOXA2 SMAD1 MLX ARNT ARID4B DMAP1 YY1 POLR2B MED15 DGCR8 ARVCF TRMT2A RPL7AP70 RPL8P5 ENSG00000273300 LOC100420177 LINC01311 DGCR11
GH22I019976 Enhancer 0.2 ENCODE 0.4 +12.7 12737 0.3 GC22P019980 MIR4761 ARVCF
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4761 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4761 Gene

Genomic Locations for MIR4761 Gene
chr22:19,963,753-19,963,834
(GRCh38/hg38)
Size:
82 bases
Orientation:
Plus strand
chr22:19,951,276-19,951,357
(GRCh37/hg19)

Genomic View for MIR4761 Gene

Genes around MIR4761 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4761 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4761 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4761 Gene

Proteins for MIR4761 Gene

Post-translational modifications for MIR4761 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4761 Gene

Domains & Families for MIR4761 Gene

Gene Families for MIR4761 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4761: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4761 Gene

Function for MIR4761 Gene

Phenotypes From GWAS Catalog for MIR4761 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4761 Gene

Localization for MIR4761 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4761 Gene

Drugs & Compounds for MIR4761 Gene

No Compound Related Data Available

Transcripts for MIR4761 Gene

mRNA/cDNA for MIR4761 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4761 Gene

No ASD Table

Relevant External Links for MIR4761 Gene

GeneLoc Exon Structure for
MIR4761
ECgene alternative splicing isoforms for
MIR4761

Expression for MIR4761 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4761 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4761 Gene:

MIR4761
genes like me logo Genes that share expression patterns with MIR4761: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4761 Gene

Orthologs for MIR4761 Gene

Evolution for MIR4761 Gene

ENSEMBL:
Gene Tree for MIR4761 (if available)
TreeFam:
Gene Tree for MIR4761 (if available)

No data available for Orthologs for MIR4761 Gene

Paralogs for MIR4761 Gene

No data available for Paralogs for MIR4761 Gene

Variants for MIR4761 Gene

Sequence variations from dbSNP and Humsavar for MIR4761 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs4680 benign, drug-response, CATECHOL-O-METHYLTRANSFERASE POLYMORPHISM, nicotine response - Efficacy, not specified 19,963,748(+) G/A upstream_transcript_variant
rs6267 risk-factor, Schizophrenia, susceptibility to 19,962,740(+) G/A/T upstream_transcript_variant
rs4633 benign, not specified 19,962,712(+) C/T upstream_transcript_variant
rs4818 benign, not specified 19,963,684(+) C/G/T upstream_transcript_variant
rs1003118478 -- 19,963,821(+) T/C non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4761 Gene

Variant ID Type Subtype PubMed ID
dgv72n68 CNV loss 17160897
dgv7983n54 CNV gain 21841781
esv3568271 CNV loss 25503493
esv3575418 CNV gain 25503493
esv3584493 CNV gain 24956385
esv3893434 CNV gain 25118596
nsv1055752 CNV gain 25217958
nsv1064496 CNV gain 25217958
nsv469641 CNV loss 16826518
nsv517165 CNV loss 19592680
nsv588240 CNV loss 21841781
nsv828938 CNV gain 20364138
nsv828939 CNV loss 20364138
nsv953026 CNV deletion 24416366

Additional Variant Information for MIR4761 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4761

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4761 Gene

Disorders for MIR4761 Gene

Additional Disease Information for MIR4761

No disorders were found for MIR4761 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4761 Gene

Publications for MIR4761 Gene

  1. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin SY … Soranzo N (Nature genetics 2014) 3 58
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4761 Gene

Sources for MIR4761 Gene

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