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Aliases for MIR4761 Gene

Subcategory (RNA class) for MIR4761 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4761 Gene

  • MicroRNA 4761 2 3
  • EC 2.1.1.6 4 61
  • COMT 4 5
  • Catechol-O-Methyltransferase 5
  • Hsa-Mir-4761 3

External Ids for MIR4761 Gene

Previous GeneCards Identifiers for MIR4761 Gene

  • GC22U900800
  • GC22P019976
  • GC22P019984
  • GC22P019992

Summaries for MIR4761 Gene

Entrez Gene Summary for MIR4761 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4761 Gene

MIR4761 (MicroRNA 4761) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. An important paralog of this gene is LRTOMT.

UniProtKB/Swiss-Prot for MIR4761 Gene

  • Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4761 Gene

Genomics for MIR4761 Gene

Regulatory Elements for MIR4761 Gene

Enhancers for MIR4761 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F019937 1.3 Ensembl ENCODE 0.8 -3.4 -3363 1.5 HDGF ELF3 ARID4B NFXL1 RAD21 RARA CREM MIXL1 THAP11 CEBPB COMT ARVCF PIR37139 MIR4761
GH22F019941 0.6 ENCODE 0.8 -1.2 -1201 0.1 ZNF362 COMT MIR4761 PIR37139
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4761 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4761 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001531228 393 2001 HDGF PKNOX1 ARNT SIN3A ARID4B DMAP1 YY1 JUNB KAT8 SREBF1

Genomic Location for MIR4761 Gene

Chromosome:
22
Start:
19,941,607 bp from pter
End:
19,969,975 bp from pter
Size:
28,369 bases
Orientation:
Plus strand

Genomic View for MIR4761 Gene

Genes around MIR4761 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4761 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4761 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4761 Gene

Proteins for MIR4761 Gene

  • Protein details for MIR4761 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21964-COMT_HUMAN
    Recommended name:
    Catechol O-methyltransferase
    Protein Accession:
    P21964
    Secondary Accessions:
    • A8MPV9
    • Q6IB07
    • Q6ICE6
    • Q9BWC7

    Protein attributes for MIR4761 Gene

    Size:
    271 amino acids
    Molecular mass:
    30037 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH00419.2; Type=Erroneous termination; Positions=85; Note=Translated as Gln.; Evidence={ECO:0000305}; Sequence=AAH05867.1; Type=Erroneous termination; Positions=85; Note=Translated as Gln.; Evidence={ECO:0000305}; Sequence=ACI46037.1; Type=Erroneous termination; Positions=85; Note=Translated as Gln.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MIR4761 Gene

    Alternative splice isoforms for MIR4761 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR4761 Gene

Selected DME Specific Peptides for MIR4761 Gene

Post-translational modifications for MIR4761 Gene

Domains & Families for MIR4761 Gene

Gene Families for MIR4761 Gene

Protein Domains for MIR4761 Gene

Graphical View of Domain Structure for InterPro Entry

P21964

UniProtKB/Swiss-Prot:

COMT_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
genes like me logo Genes that share domains with MIR4761: view

No data available for Suggested Antigen Peptide Sequences for MIR4761 Gene

Function for MIR4761 Gene

Molecular function for MIR4761 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.
UniProtKB/Swiss-Prot Function:
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

Enzyme Numbers (IUBMB) for MIR4761 Gene

Gene Ontology (GO) - Molecular Function for MIR4761 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0008171 O-methyltransferase activity IEA --
GO:0016206 catechol O-methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MIR4761: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4761 Gene

Localization for MIR4761 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4761 Gene

Isoform Soluble: Cytoplasm.
Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side.

Gene Ontology (GO) - Cellular Components for MIR4761 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MIR4761: view

No data available for Subcellular locations from COMPARTMENTS for MIR4761 Gene

Pathways & Interactions for MIR4761 Gene

genes like me logo Genes that share pathways with MIR4761: view

Gene Ontology (GO) - Biological Process for MIR4761 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006584 catecholamine metabolic process IEA --
GO:0007565 female pregnancy IEA --
GO:0007612 learning IEA --
GO:0007614 short-term memory IEA --
GO:0008210 estrogen metabolic process IEA --
genes like me logo Genes that share ontologies with MIR4761: view

No data available for SIGNOR curated interactions for MIR4761 Gene

Transcripts for MIR4761 Gene

mRNA/cDNA for MIR4761 Gene

(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4761 Gene

No ASD Table

Relevant External Links for MIR4761 Gene

GeneLoc Exon Structure for
MIR4761
ECgene alternative splicing isoforms for
MIR4761

Expression for MIR4761 Gene

mRNA expression in normal human tissues for MIR4761 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4761 Gene:

MIR4761

mRNA Expression by UniProt/SwissProt for MIR4761 Gene:

P21964-COMT_HUMAN
Tissue specificity: Brain, liver, placenta, lymphocytes and erythrocytes.
genes like me logo Genes that share expression patterns with MIR4761: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR4761 Gene

Orthologs for MIR4761 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR4761 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COMT 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COMT 35
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COMT 35
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Comt 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COMT 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COMT 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves COMT 35
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii comta 35
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToOne
Species where no ortholog for MIR4761 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR4761 Gene

ENSEMBL:
Gene Tree for MIR4761 (if available)
TreeFam:
Gene Tree for MIR4761 (if available)

Paralogs for MIR4761 Gene

Paralogs for MIR4761 Gene

genes like me logo Genes that share paralogs with MIR4761: view

Variants for MIR4761 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MIR4761 Gene

COMT_HUMAN-P21964
Low enzyme activity alleles are associated with genetic susceptibility to alcoholism [MIM:103780].
COMT_HUMAN-P21964
Two alleles, COMT*1 or COMT*H with Val-158 and COMT*2 or COMT*L with Met-158 are responsible for a three to four-fold difference in enzymatic activity.

Sequence variations from dbSNP and Humsavar for MIR4761 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs4680 drug-response 19,963,748(+) CTGGC(A/G)TGAAG upstream-variant-2KB, reference, missense
rs4633 Benign 19,962,712(+) AACCA(C/T)GTGCT upstream-variant-2KB, reference, synonymous-codon
rs4818 Benign 19,963,684(+) AGGCT(C/G)ATCAC upstream-variant-2KB, reference, synonymous-codon
rs6267 other 19,962,740(+) GGAAC(A/G/T)CACAG upstream-variant-2KB, reference, missense
rs111359353 -- 19,963,931(+) CCAGC(A/G)GCTCA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR4761 Gene

Variant ID Type Subtype PubMed ID
dgv72n68 CNV loss 17160897
dgv7983n54 CNV gain 21841781
esv3568271 CNV loss 25503493
esv3575418 CNV gain 25503493
esv3584493 CNV gain 24956385
esv3893434 CNV gain 25118596
nsv1055752 CNV gain 25217958
nsv1064496 CNV gain 25217958
nsv469641 CNV loss 16826518
nsv517165 CNV loss 19592680
nsv588240 CNV loss 21841781
nsv828938 CNV gain 20364138
nsv828939 CNV loss 20364138
nsv953026 CNV deletion 24416366

Relevant External Links for MIR4761 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4761

No data available for Variation tolerance for MIR4761 Gene

Disorders for MIR4761 Gene

Relevant External Links for MIR4761

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4761

No disorders were found for MIR4761 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4761 Gene

Publications for MIR4761 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  2. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3 64
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  4. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64

Products for MIR4761 Gene

Sources for MIR4761 Gene

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