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Aliases for MIR4759 Gene

Subcategory (RNA class) for MIR4759 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4759 Gene

  • MicroRNA 4759 2 3 5
  • Hsa-Mir-4759 3

External Ids for MIR4759 Gene

Previous GeneCards Identifiers for MIR4759 Gene

  • GC21U900450
  • GC21P028328

Summaries for MIR4759 Gene

Entrez Gene Summary for MIR4759 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4759 Gene

MIR4759 (MicroRNA 4759) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4759 Gene

Genomics for MIR4759 Gene

Regulatory Elements for MIR4759 Gene

Enhancers for MIR4759 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21F026954 0.9 VISTA ENCODE 0.8 +1.4 1363 2.6 SMARCA4 POLR2A LOC105372760 MIR4759 ADAMTS5
GH21F026961 1.5 FANTOM5 Ensembl ENCODE 0.4 +11.2 11186 6.8 ELF3 TBP RAD21 YY1 SCRT2 FOS ZNF202 ZNF263 ZNF654 CEBPB ADAMTS5 ADAMTS1 MIR4759
GH21F026945 0.8 FANTOM5 Ensembl ENCODE 0.4 -7.4 -7373 1.6 ADAMTS5 LOC105372760 CYYR1 MIR4759 GC21M026919
GH21F026962 0.6 Ensembl 0.4 +7.5 7540 0.2 TEAD1 CEBPA BHLHE40 CEBPB FOS ADAMTS5 MIR4759
GH21F026939 0.4 ENCODE 0.4 -14.0 -14041 1.1 SMARCA4 ADAMTS5 LOC105372760 MIR4759 GC21M026919
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4759 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4759 Gene

Chromosome:
21
Start:
26,953,961 bp from pter
End:
26,954,043 bp from pter
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIR4759 Gene

Genes around MIR4759 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4759 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4759 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4759 Gene

Proteins for MIR4759 Gene

Post-translational modifications for MIR4759 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4759 Gene

Domains & Families for MIR4759 Gene

Gene Families for MIR4759 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4759: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4759 Gene

Function for MIR4759 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4759 Gene

Localization for MIR4759 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4759 Gene

Pathways & Interactions for MIR4759 Gene

SuperPathways for MIR4759 Gene

No Data Available

Interacting Proteins for MIR4759 Gene

Gene Ontology (GO) - Biological Process for MIR4759 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4759 Gene

Transcripts for MIR4759 Gene

mRNA/cDNA for MIR4759 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4759 Gene

No ASD Table

Relevant External Links for MIR4759 Gene

GeneLoc Exon Structure for
MIR4759
ECgene alternative splicing isoforms for
MIR4759

Expression for MIR4759 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4759 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4759 Gene:

MIR4759
genes like me logo Genes that share expression patterns with MIR4759: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4759 Gene

Orthologs for MIR4759 Gene

Evolution for MIR4759 Gene

ENSEMBL:
Gene Tree for MIR4759 (if available)
TreeFam:
Gene Tree for MIR4759 (if available)

No data available for Orthologs for MIR4759 Gene

Paralogs for MIR4759 Gene

No data available for Paralogs for MIR4759 Gene

Variants for MIR4759 Gene

Sequence variations from dbSNP and Humsavar for MIR4759 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs114061426 -- 26,953,253(+) GAGCT(C/G)GGACT intron-variant, upstream-variant-2KB
rs13051209 -- 26,952,181(+) AATAA(A/C)CAAAG intron-variant, upstream-variant-2KB
rs13051297 -- 26,952,169(+) GACTT(C/T)TAAAG intron-variant, upstream-variant-2KB
rs140724460 -- 26,953,967(+) ATTTA(A/G)GACTA intron-variant, nc-transcript-variant
rs140746116 -- 26,954,462(+) TTTAC(A/G)GATGC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR4759 Gene

Variant ID Type Subtype PubMed ID
nsv1066573 CNV gain 25217958
nsv834068 CNV loss 17160897

Relevant External Links for MIR4759 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4759

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4759 Gene

Disorders for MIR4759 Gene

Relevant External Links for MIR4759

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4759

No disorders were found for MIR4759 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4759 Gene

Publications for MIR4759 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4759 Gene

Sources for MIR4759 Gene

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