Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR4758 Gene

Subcategory (RNA class) for MIR4758 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4758 Gene

  • MicroRNA 4758 2 3
  • LAMA5 4 5
  • Laminin-10 Subunit Alpha 4
  • Laminin-11 Subunit Alpha 4
  • Laminin-15 Subunit Alpha 4
  • Laminin Subunit Alpha 5 5
  • Hsa-Mir-4758 3
  • KIAA0533 4
  • KIAA1907 4

External Ids for MIR4758 Gene

Previous GeneCards Identifiers for MIR4758 Gene

  • GC20U900689
  • GC20M060910
  • GC20M060912

Summaries for MIR4758 Gene

Entrez Gene Summary for MIR4758 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4758 Gene

MIR4758 (MicroRNA 4758) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Immune System and Primary Focal Segmental Glomerulosclerosis FSGS. An important paralog of this gene is LAMA3.

UniProtKB/Swiss-Prot for MIR4758 Gene

  • Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4758 Gene

Genomics for MIR4758 Gene

Regulatory Elements for MIR4758 Gene

Enhancers for MIR4758 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F062500 1.3 FANTOM5 Ensembl ENCODE 30.3 -134.3 -134290 3.2 HDGF PKNOX1 ATF1 ZNF133 ARID4B YBX1 ZNF2 GLIS2 ZNF207 ZNF143 MIR4758 ENSG00000226332 DPH3P1 OGFR DIDO1 GC20M062490 PIR36870
GH20F063260 0.2 ENCODE 20.8 -894.2 -894184 1.7 SAP130 ZNF133 KLF17 NFXL1 YBX1 ZIC2 ZBTB40 ZKSCAN1 FOSL1 ZNF791 BIRC7 MIR647 MIR1914 MIR4758 NKAIN4 ENSG00000237371 COL20A1 RNU6-994P ENSG00000226332 PRPF6
GH20F062344 0.7 ENCODE 12.6 +22.4 22393 0.2 BHLHE40 LAMA5 MIR4758 RPS21 ENSG00000226332 ADRM1 LAMA5-AS1 LOC105372707
GH20F062385 0.2 ENCODE 12.1 -20.0 -20014 3.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 SLC30A9 ZNF416 ZNF143 ZNF207 SP3 LINC00029 CABLES2 LINC01056 MIR4758 ENSG00000226332 GATA5 MRGBP OSBPL2 GC20M062395 RPS21
GH20F062275 0.5 ENCODE 12 +90.4 90376 1.9 CTCF ZNF654 ZNF600 RAD21 LAMA5 MIR4758 HRH3 MTG2 LAMA5-AS1 CABLES2 GC20M062290 OSBPL2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4758 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4758 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001839098 612 2201 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ZNF121 GLIS2 KLF7 FOS SP3
ENSR00001839099 -1388 201 ELF3 TBP ZSCAN9 DNMT3B SLC30A9 GLIS2 CREM MIXL1 EGR2 SP3
ENSR00000404083 -1788 201 ELF3 MLX SIN3A ZNF48 ZSCAN9 CREM MXD4 REST PPARG SMARCB1

Genomic Location for MIR4758 Gene

Chromosome:
20
Start:
62,307,955 bp from pter
End:
62,367,312 bp from pter
Size:
59,358 bases
Orientation:
Minus strand

Genomic View for MIR4758 Gene

Genes around MIR4758 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4758 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4758 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4758 Gene

Proteins for MIR4758 Gene

  • Protein details for MIR4758 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15230-LAMA5_HUMAN
    Recommended name:
    Laminin subunit alpha-5
    Protein Accession:
    O15230
    Secondary Accessions:
    • Q5U4N9
    • Q8TDF8
    • Q8WZA7
    • Q9H1P1

    Protein attributes for MIR4758 Gene

    Size:
    3695 amino acids
    Molecular mass:
    399737 Da
    Quaternary structure:
    • Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-5 is a subunit of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523).
    • Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-5 is a subunit of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523).
    SequenceCaution:
    • Sequence=CAC22310.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR4758 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR4758 Gene

Post-translational modifications for MIR4758 Gene

  • Ubiquitination at Lys 192
  • Glycosylation at Asn 95, Asn 143, Asn 243, Asn 452, Asn 479, Asn 900, Asn 921, Asn 959, Asn 1330, Asn 1529, Asn 1555, Asn 2019, Asn 2196, Asn 2209, Asn 2303, Asn 2423, Asn 2501, Asn 2568, Asn 2707, Asn 3107, Asn 3209, Asn 3257, Asn 3287, and Asn 3626
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR4758 Gene

No data available for DME Specific Peptides for MIR4758 Gene

Domains & Families for MIR4758 Gene

Gene Families for MIR4758 Gene

Graphical View of Domain Structure for InterPro Entry

O15230

UniProtKB/Swiss-Prot:

LAMA5_HUMAN :
  • Domain G is globular and is part of the major cell-binding site located in the long arm of the laminin heterotrimer.
Domain:
  • Domain G is globular and is part of the major cell-binding site located in the long arm of the laminin heterotrimer.
  • Contains 22 laminin EGF-like domains.
  • Contains 5 laminin G-like domains.
  • Contains 1 laminin IV type A domain.
  • Contains 1 laminin N-terminal domain.
genes like me logo Genes that share domains with MIR4758: view

No data available for Suggested Antigen Peptide Sequences for MIR4758 Gene

Function for MIR4758 Gene

Molecular function for MIR4758 Gene

UniProtKB/Swiss-Prot Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Gene Ontology (GO) - Molecular Function for MIR4758 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005178 integrin binding IEA --
GO:0005198 structural molecule activity IC --
genes like me logo Genes that share ontologies with MIR4758: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4758 Gene

Localization for MIR4758 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4758 Gene

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Gene Ontology (GO) - Cellular Components for MIR4758 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005604 basement membrane IDA --
GO:0005605 basal lamina IEA --
GO:0005610 laminin-5 complex IEA --
genes like me logo Genes that share ontologies with MIR4758: view

No data available for Subcellular locations from COMPARTMENTS for MIR4758 Gene

Pathways & Interactions for MIR4758 Gene

genes like me logo Genes that share pathways with MIR4758: view

Gene Ontology (GO) - Biological Process for MIR4758 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0001738 morphogenesis of a polarized epithelium IEA --
GO:0001755 neural crest cell migration IEA --
GO:0001942 hair follicle development IEA --
GO:0007010 cytoskeleton organization NAS --
genes like me logo Genes that share ontologies with MIR4758: view

No data available for SIGNOR curated interactions for MIR4758 Gene

Transcripts for MIR4758 Gene

mRNA/cDNA for MIR4758 Gene

(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4758 Gene

No ASD Table

Relevant External Links for MIR4758 Gene

GeneLoc Exon Structure for
MIR4758
ECgene alternative splicing isoforms for
MIR4758

Expression for MIR4758 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4758 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4758 Gene:

MIR4758

mRNA Expression by UniProt/SwissProt for MIR4758 Gene:

O15230-LAMA5_HUMAN
Tissue specificity: Expressed in heart, lung, kidney, skeletal muscle, pancreas, retina and placenta. Little or no expression in brain and liver.
genes like me logo Genes that share expression patterns with MIR4758: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR4758 Gene

Orthologs for MIR4758 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR4758 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LAMA5 35
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lama5 35
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LAMA5 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LAMA5 35
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LAMA5 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves LAMA5 35
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 62 (a)
OneToMany
-- 35
  • 47 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii lama5 35
  • 50 (a)
OneToOne
Species where no ortholog for MIR4758 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR4758 Gene

ENSEMBL:
Gene Tree for MIR4758 (if available)
TreeFam:
Gene Tree for MIR4758 (if available)

Paralogs for MIR4758 Gene

Paralogs for MIR4758 Gene

genes like me logo Genes that share paralogs with MIR4758: view

Variants for MIR4758 Gene

Sequence variations from dbSNP and Humsavar for MIR4758 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1105019 -- 62,334,462(+) GGAGA(G/T)GCCCG intron-variant, upstream-variant-2KB
rs111560430 -- 62,333,483(+) AGTCC(A/T)GCAGG upstream-variant-2KB, splice-acceptor-variant
rs111777697 -- 62,332,224(+) GAGGG(A/G)TTCCA intron-variant, downstream-variant-500B
rs112012816 -- 62,332,356(+) GGGGA(C/T)CTGAG intron-variant, downstream-variant-500B
rs112350373 -- 62,334,004(+) AGGTC(-/A)GGGGA nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4758 Gene

Variant ID Type Subtype PubMed ID
dgv518n27 CNV loss 19166990
dgv7650n54 CNV loss 21841781
dgv7651n54 CNV loss 21841781
dgv7652n54 CNV loss 21841781
esv2422398 CNV duplication 17116639
nsv459059 CNV loss 19166990
nsv459065 CNV gain 19166990
nsv470556 CNV loss 18288195
nsv470557 CNV gain 18288195
nsv518296 CNV loss 19592680
nsv520024 CNV loss 19592680
nsv586496 CNV gain 21841781
nsv817908 CNV loss 17921354
nsv834024 CNV gain 17160897
nsv953301 CNV deletion 24416366

Relevant External Links for MIR4758 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4758

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4758 Gene

Disorders for MIR4758 Gene

Relevant External Links for MIR4758

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4758

No disorders were found for MIR4758 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4758 Gene

Publications for MIR4758 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  2. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3 64
  3. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
  5. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PMID: 19159218) Chen R. … Zou H. (J. Proteome Res. 2009) 4 64

Products for MIR4758 Gene

Sources for MIR4758 Gene

Content
Loading form....