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Aliases for MIR4758 Gene

Subcategory (RNA class) for MIR4758 Gene


Quality Score for this RNA gene is


Aliases for MIR4758 Gene

  • MicroRNA 4758 2 3 5
  • Hsa-Mir-4758 3

External Ids for MIR4758 Gene

Previous GeneCards Identifiers for MIR4758 Gene

  • GC20U900689
  • GC20M060910
  • GC20M060912

Summaries for MIR4758 Gene

Entrez Gene Summary for MIR4758 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4758 Gene

MIR4758 (MicroRNA 4758) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are ECM proteoglycans and MET promotes cell motility.

Additional gene information for MIR4758 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4758 Gene

Genomics for MIR4758 Gene

Regulatory Elements for MIR4758 Gene

Enhancers for MIR4758 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H062337 1.5 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -6.4 -6427 2.8 MAZ TBL1XR1 RELA SP1 ZFHX2 POLR2A BCL11A IKZF1 EED ATF7 LAMA5 MTG2 LAMA5-AS1 MIR4758
GH20H062350 1.2 ENCODE dbSUPER 0.4 -18.2 -18245 2 TBP HDGF NFIB SIN3A KLF17 ZEB1 ZNF121 GLIS2 HSF1 SCRT2 LAMA5 DIDO1 LAMA5-AS1 MIR4758
GH20H062321 0.9 ENCODE dbSUPER 0.4 +11.3 11348 0 MAZ SP3 ESRRA KLF1 CDC5L CTBP1 HNF4G KLF9 NR2C1 TRIM24 MIR4758 LOC105372707
GH20H062343 0.8 ENCODE 0.4 -10.6 -10573 0 SOX13 TFAP4 FOXA2 NFIB SAP130 ARID4B ZBTB40 HOMEZ MIXL1 GATAD2A LAMA5-AS1 MIR4758
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4758 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4758 Gene

Genomic Locations for MIR4758 Gene
71 bases
Minus strand

Genomic View for MIR4758 Gene

Genes around MIR4758 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4758 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4758 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4758 Gene

ORGUL Member Location for MIR4758 Gene

ORGUL Member Location for MIR4758 gene

Proteins for MIR4758 Gene

Post-translational modifications for MIR4758 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4758 Gene

Domains & Families for MIR4758 Gene

Gene Families for MIR4758 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4758: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4758 Gene

Function for MIR4758 Gene

Phenotypes From GWAS Catalog for MIR4758 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4758 Gene

Localization for MIR4758 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4758 Gene

Pathways & Interactions for MIR4758 Gene

genes like me logo Genes that share pathways with MIR4758: view

Interacting Proteins for MIR4758 Gene

Gene Ontology (GO) - Biological Process for MIR4758 Gene


No data available for SIGNOR curated interactions for MIR4758 Gene

Drugs & Compounds for MIR4758 Gene

No Compound Related Data Available

Transcripts for MIR4758 Gene

mRNA/cDNA for MIR4758 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4758 Gene

No ASD Table

Relevant External Links for MIR4758 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4758 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4758 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4758 Gene:

genes like me logo Genes that share expression patterns with MIR4758: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4758 Gene

Orthologs for MIR4758 Gene

Evolution for MIR4758 Gene

Gene Tree for MIR4758 (if available)
Gene Tree for MIR4758 (if available)

No data available for Orthologs for MIR4758 Gene

Paralogs for MIR4758 Gene

No data available for Paralogs for MIR4758 Gene

Variants for MIR4758 Gene

Sequence variations from dbSNP and Humsavar for MIR4758 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000529654 -- 62,333,216(+) CCATC(C/G)AGGGG nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon
rs1000646033 -- 62,333,817(+) CAGAG(A/G)AAGGT intron-variant, upstream-variant-2KB
rs1001245604 -- 62,332,865(+) TGGGG(G/T)CTGAG intron-variant, upstream-variant-2KB
rs1005716615 -- 62,333,742(+) CCCAG(C/T)CCTTG intron-variant, upstream-variant-2KB
rs1006597016 -- 62,332,886(+) AGGCC(A/G)CAGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4758 Gene

Variant ID Type Subtype PubMed ID
nsv953301 CNV deletion 24416366
nsv834024 CNV gain 17160897
nsv817908 CNV loss 17921354
nsv586496 CNV gain 21841781
nsv520024 CNV loss 19592680
nsv518296 CNV loss 19592680
nsv470557 CNV gain 18288195
nsv470556 CNV loss 18288195
nsv459065 CNV gain 19166990
nsv459059 CNV loss 19166990
esv2422398 CNV duplication 17116639
dgv7652n54 CNV loss 21841781
dgv7651n54 CNV loss 21841781
dgv7650n54 CNV loss 21841781
dgv518n27 CNV loss 19166990

Relevant External Links for MIR4758 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4758 Gene

Disorders for MIR4758 Gene

Relevant External Links for MIR4758

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR4758 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4758 Gene

Publications for MIR4758 Gene

  1. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles RA … Easton DF (Nature genetics 2013) 3 60
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 60
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR4758 Gene

Sources for MIR4758 Gene

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