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Aliases for MIR4750 Gene

Subcategory (RNA class) for MIR4750 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4750 Gene

  • MicroRNA 4750 2 3 5
  • Hsa-Mir-4750 3
  • Mir-4750 3

External Ids for MIR4750 Gene

Previous GeneCards Identifiers for MIR4750 Gene

  • GC19U901543
  • GC19P050393

Summaries for MIR4750 Gene

Entrez Gene Summary for MIR4750 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4750 Gene

MIR4750 (MicroRNA 4750) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Vesicle-mediated transport and TBC/RABGAPs.

Additional gene information for MIR4750 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4750 Gene

Genomics for MIR4750 Gene

GeneHancer (GH) Regulatory Elements for MIR4750 Gene

Promoters and enhancers for MIR4750 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I049889 Enhancer 1.4 Ensembl ENCODE dbSUPER 0.8 +2.6 2564 2.2 HDGF PKNOX1 SMAD1 ARNT SIN3A ZNF2 ZNF766 CBX5 E2F8 ZNF207 ENSG00000268047 PTOV1 SNRNP70 PRR12 CLEC11A PTOV1-AS2 PRMT1 PNKP MIR4750 PIR32099
GH19I049894 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.4 +8.5 8453 4.1 HDGF PKNOX1 ATF1 IRF4 ZNF766 GLIS2 ZNF143 ATF7 FOS RUNX3 IL4I1 NUP62 POLD1 AKT1S1 MED25 NR1H2 PNKP PTOV1-AS2 ATF5 TBC1D17
GH19I049879 Enhancer 0.8 ENCODE dbSUPER 0.4 -8.7 -8696 0.2 ZNF362 ZBTB11 SP2 SIX5 ZBTB40 GABPA GABPB1 CREB1 ZNF143 CREM AKT1S1 PNKP TBC1D17 MIR4750
GH19I049905 Enhancer 0.6 ENCODE 0.4 +18.4 18399 1.2 PKNOX1 ZNF687 BACH1 POLR2A IKZF1 ZNF143 ZFP36 SUPT5H PIR32099 AKT1S1 TBC1D17 PTOV1 ENSG00000221125 ATF5 IL4I1 MIR4750 NUP62
GH19I049893 Enhancer 0.4 Ensembl dbSUPER 0.4 +5.6 5626 0.4 MIR4750 PIR32099 IL4I1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4750 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4750 Gene

Genomic Locations for MIR4750 Gene
chr19:49,888,175-49,888,230
(GRCh38/hg38)
Size:
56 bases
Orientation:
Plus strand
chr19:50,391,428-50,391,494
(GRCh37/hg19)

Genomic View for MIR4750 Gene

Genes around MIR4750 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4750 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4750 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4750 Gene

Proteins for MIR4750 Gene

Post-translational modifications for MIR4750 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4750 Gene

Domains & Families for MIR4750 Gene

Gene Families for MIR4750 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4750: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4750 Gene

Function for MIR4750 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4750 Gene

Localization for MIR4750 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4750 Gene

Pathways & Interactions for MIR4750 Gene

genes like me logo Genes that share pathways with MIR4750: view

Pathways by source for MIR4750 Gene

3 Reactome pathways for MIR4750 Gene

Interacting Proteins for MIR4750 Gene

Gene Ontology (GO) - Biological Process for MIR4750 Gene

None

No data available for SIGNOR curated interactions for MIR4750 Gene

Drugs & Compounds for MIR4750 Gene

No Compound Related Data Available

Transcripts for MIR4750 Gene

mRNA/cDNA for MIR4750 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4750 Gene

No ASD Table

Relevant External Links for MIR4750 Gene

GeneLoc Exon Structure for
MIR4750
ECgene alternative splicing isoforms for
MIR4750

Expression for MIR4750 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4750 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4750 Gene:

MIR4750
genes like me logo Genes that share expression patterns with MIR4750: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4750 Gene

Orthologs for MIR4750 Gene

Evolution for MIR4750 Gene

ENSEMBL:
Gene Tree for MIR4750 (if available)
TreeFam:
Gene Tree for MIR4750 (if available)

No data available for Orthologs for MIR4750 Gene

Paralogs for MIR4750 Gene

No data available for Paralogs for MIR4750 Gene

Variants for MIR4750 Gene

Sequence variations from dbSNP and Humsavar for MIR4750 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000555472 -- 49,888,326(+) C/T downstream_transcript_variant
rs1001515127 -- 49,887,209(+) G/T upstream_transcript_variant
rs1002485292 -- 49,886,473(+) C/T upstream_transcript_variant
rs1002516331 -- 49,886,196(+) C/T upstream_transcript_variant
rs1003458505 -- 49,887,257(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4750 Gene

Variant ID Type Subtype PubMed ID
dgv53n68 CNV loss 17160897
dgv54n68 CNV loss 17160897
esv3644628 CNV gain 21293372
esv3644630 CNV gain 21293372
nsv1140251 OTHER inversion 24896259
nsv2519 CNV deletion 18451855
nsv524068 CNV loss 19592680
nsv953600 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Additional Variant Information for MIR4750 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4750

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4750 Gene

Disorders for MIR4750 Gene

Additional Disease Information for MIR4750

No disorders were found for MIR4750 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4750 Gene

Publications for MIR4750 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4750 Gene

Sources for MIR4750 Gene

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