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Aliases for MIR4746 Gene

Subcategory (RNA class) for MIR4746 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4746 Gene

  • MicroRNA 4746 2 3 5
  • Hsa-Mir-4746 3
  • Mir-4746 3

External Ids for MIR4746 Gene

Previous GeneCards Identifiers for MIR4746 Gene

  • GC19U901556
  • GC19P004449

Summaries for MIR4746 Gene

Entrez Gene Summary for MIR4746 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4746 Gene

MIR4746 (MicroRNA 4746) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4746 Gene

Genomics for MIR4746 Gene

Regulatory Elements for MIR4746 Gene

Enhancers for MIR4746 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G004445 1 ENCODE dbSUPER 0.7 +0.5 544 2.8 AGO1 ZNF837 ZNF2 ZIC2 ZEB1 HIC1 GLIS2 POLR2A SCRT2 PATZ1 UBXN6 CHAF1A SH3GL1 MRPL54 ENSG00000267769 ENSG00000267030 MIR4746
GH19G004429 1 Ensembl ENCODE 0.4 -15.0 -14975 3.8 MAX ZFHX2 EGR1 POLR2A EED SCRT2 IKZF2 CREM EGR2 SCRT1 ENSG00000267769 CHAF1A CACTIN-AS1 ENSG00000267255 MIR4746
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4746 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4746 Gene

Chromosome:
19
Start:
4,445,978 bp from pter
End:
4,446,048 bp from pter
Size:
71 bases
Orientation:
Plus strand

Genomic View for MIR4746 Gene

Genes around MIR4746 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4746 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4746 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4746 Gene

Proteins for MIR4746 Gene

Post-translational modifications for MIR4746 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4746 Gene

Domains & Families for MIR4746 Gene

Gene Families for MIR4746 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4746: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4746 Gene

Function for MIR4746 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4746 Gene

Localization for MIR4746 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4746 Gene

Pathways & Interactions for MIR4746 Gene

SuperPathways for MIR4746 Gene

No Data Available

Interacting Proteins for MIR4746 Gene

Gene Ontology (GO) - Biological Process for MIR4746 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4746 Gene

Drugs & Compounds for MIR4746 Gene

No Compound Related Data Available

Transcripts for MIR4746 Gene

mRNA/cDNA for MIR4746 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4746 Gene

No ASD Table

Relevant External Links for MIR4746 Gene

GeneLoc Exon Structure for
MIR4746
ECgene alternative splicing isoforms for
MIR4746

Expression for MIR4746 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4746 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4746 Gene:

MIR4746
genes like me logo Genes that share expression patterns with MIR4746: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4746 Gene

Orthologs for MIR4746 Gene

Evolution for MIR4746 Gene

ENSEMBL:
Gene Tree for MIR4746 (if available)
TreeFam:
Gene Tree for MIR4746 (if available)

No data available for Orthologs for MIR4746 Gene

Paralogs for MIR4746 Gene

No data available for Paralogs for MIR4746 Gene

Variants for MIR4746 Gene

Sequence variations from dbSNP and Humsavar for MIR4746 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000034734 -- 4,444,649(+) ACCTT(C/T)CATCA intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1000061425 -- 4,444,059(+) TGAAG(C/T)AGAGG intron-variant, upstream-variant-2KB
rs1000147570 -- 4,444,820(+) CCTCC(A/C)CTAGC intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1000484037 -- 4,445,705(+) GGCGC(A/G)GGGAT intron-variant, upstream-variant-2KB
rs1002926427 -- 4,445,772(+) CTGCC(C/T)TCTCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4746 Gene

Variant ID Type Subtype PubMed ID
nsv833718 CNV loss 17160897
nsv833720 CNV loss 17160897

Relevant External Links for MIR4746 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4746

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4746 Gene

Disorders for MIR4746 Gene

Relevant External Links for MIR4746

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4746

No disorders were found for MIR4746 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4746 Gene

Publications for MIR4746 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4746 Gene

Sources for MIR4746 Gene

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