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Aliases for MIR4746 Gene

Subcategory (RNA class) for MIR4746 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4746 Gene

  • MicroRNA 4746 2 3
  • Hsa-Mir-4746 3

External Ids for MIR4746 Gene

Previous GeneCards Identifiers for MIR4746 Gene

  • GC19U901556
  • GC19P004449

Summaries for MIR4746 Gene

Entrez Gene Summary for MIR4746 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4746 Gene

MIR4746 (MicroRNA 4746) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4746 Gene

Genomics for MIR4746 Gene

Genomic Location for MIR4746 Gene

Start:
4,445,978 bp from pter
End:
4,446,048 bp from pter
Size:
71 bases
Orientation:
Plus strand

Genomic View for MIR4746 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR4746 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4746 Gene

No data available for Regulatory Elements for MIR4746 Gene

Proteins for MIR4746 Gene

Post-translational modifications for MIR4746 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4746 Gene

Domains for MIR4746 Gene

Gene Families for MIR4746 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4746: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4746 Gene

Function for MIR4746 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR4746 Gene

Localization for MIR4746 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4746 Gene

Pathways for MIR4746 Gene

SuperPathways for MIR4746 Gene

No Data Available

Interacting Proteins for MIR4746 Gene

Gene Ontology (GO) - Biological Process for MIR4746 Gene

None

No data available for Pathways by source for MIR4746 Gene

Transcripts for MIR4746 Gene

mRNA/cDNA for MIR4746 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4746 Gene

No ASD Table

Relevant External Links for MIR4746 Gene

GeneLoc Exon Structure for
MIR4746
ECgene alternative splicing isoforms for
MIR4746

Expression for MIR4746 Gene

mRNA expression in normal human tissues for MIR4746 Gene

genes like me logo Genes that share expressions with MIR4746: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR4746 Gene

Orthologs for MIR4746 Gene

Evolution for MIR4746 Gene

ENSEMBL:
Gene Tree for MIR4746 (if available)
TreeFam:
Gene Tree for MIR4746 (if available)

No data available for Orthologs for MIR4746 Gene

Paralogs for MIR4746 Gene

No data available for Paralogs for MIR4746 Gene

Variants for MIR4746 Gene

Sequence variations from dbSNP and Humsavar for MIR4746 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs376623 -- 4,444,497(-) CGCCT(A/C)CGAGC upstream-variant-2KB
rs376624 -- 4,444,496(-) GCCTC(C/T)GAGCA upstream-variant-2KB
rs62130981 -- 4,444,446(+) GCTAA(C/T)ATCAA upstream-variant-2KB
rs74172642 -- 4,444,324(+) GCCTT(C/G)CACAC upstream-variant-2KB
rs80124426 -- 4,444,179(+) CAGGC(C/T)GGGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4746 Gene

Variant ID Type Subtype PubMed ID
nsv910817 CNV Loss 21882294
nsv833718 CNV Loss 17160897
nsv910820 CNV Gain 21882294
dgv3674n71 CNV Loss 21882294
nsv910827 CNV Loss 21882294
nsv833720 CNV Loss 17160897
dgv3676n71 CNV Loss 21882294
dgv3677n71 CNV Loss 21882294

Relevant External Links for MIR4746 Gene

HapMap Linkage Disequilibrium report
MIR4746

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR4746 Gene

Disorders for MIR4746 Gene

No disorders were found for MIR4746 Gene.

No data available for UniProtKB/Swiss-Prot for MIR4746 Gene

Publications for MIR4746 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3

Products for MIR4746 Gene

Sources for MIR4746 Gene

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