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Aliases for MIR4745 Gene

Subcategory (RNA class) for MIR4745 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4745 Gene

  • MicroRNA 4745 2 3 5
  • Hsa-Mir-4745 3
  • Mir-4745 3

External Ids for MIR4745 Gene

Previous GeneCards Identifiers for MIR4745 Gene

  • GC19U901548
  • GC19P000809
  • GC19P000815
  • GC19P000806

Summaries for MIR4745 Gene

Entrez Gene Summary for MIR4745 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4745 Gene

MIR4745 (MicroRNA 4745) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4745 Gene

Genomics for MIR4745 Gene

Regulatory Elements for MIR4745 Gene

Enhancers for MIR4745 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G000807 0.7 dbSUPER 0.7 +1.9 1932 1.6 ZNF263 SMAD5 FUS BACH1 CCNT2 HIC1 CBX1 POLR2A PRPF4 ZBTB33 TMEM259 MIER2 POLRMT ENSG00000267317 MIR4745 MIR3187
GH19G000806 0.6 dbSUPER 0.7 +2.3 2283 0.5 ZNF263 HIC1 SMAD5 POLR2A ZBTB33 SUPT5H RBFOX2 MIR4745 MIR3187
GH19G000804 0.5 dbSUPER 0.7 +0.0 18 0.9 CTCF HIC1 POLR2A RBFOX2 MIR4745 MIR3187
GH19G000805 0.5 dbSUPER 0.7 -0.6 -560 0.6 HIC1 POLR2A NR2F2 RBFOX2 LOC101928450 MIR4745 PIR40584
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4745 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4745 Gene

Chromosome:
19
Start:
804,940 bp from pter
End:
805,001 bp from pter
Size:
62 bases
Orientation:
Plus strand

Genomic View for MIR4745 Gene

Genes around MIR4745 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4745 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4745 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4745 Gene

Proteins for MIR4745 Gene

Post-translational modifications for MIR4745 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4745 Gene

Domains & Families for MIR4745 Gene

Gene Families for MIR4745 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4745: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4745 Gene

Function for MIR4745 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4745 Gene

Localization for MIR4745 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4745 Gene

Pathways & Interactions for MIR4745 Gene

genes like me logo Genes that share pathways with MIR4745: view

Interacting Proteins for MIR4745 Gene

Gene Ontology (GO) - Biological Process for MIR4745 Gene

None

No data available for SIGNOR curated interactions for MIR4745 Gene

Transcripts for MIR4745 Gene

mRNA/cDNA for MIR4745 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4745 Gene

No ASD Table

Relevant External Links for MIR4745 Gene

GeneLoc Exon Structure for
MIR4745
ECgene alternative splicing isoforms for
MIR4745

Expression for MIR4745 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4745 Gene:

MIR4745
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4745 Gene

Orthologs for MIR4745 Gene

Evolution for MIR4745 Gene

ENSEMBL:
Gene Tree for MIR4745 (if available)
TreeFam:
Gene Tree for MIR4745 (if available)

No data available for Orthologs for MIR4745 Gene

Paralogs for MIR4745 Gene

No data available for Paralogs for MIR4745 Gene

Variants for MIR4745 Gene

Sequence variations from dbSNP and Humsavar for MIR4745 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000808315 -- 805,054(+) ACGCT(A/G)CGCAT nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon
rs1002348566 -- 804,301(+) TCATC(A/G)AGATG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1002687869 -- 803,493(+) AGGGC(C/T)GGCCG intron-variant, upstream-variant-2KB
rs1002737027 -- 805,263(+) CGGCA(C/T)GGGCC intron-variant, downstream-variant-500B
rs1003128385 -- 803,317(+) CTGGC(C/T)GAGTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4745 Gene

Variant ID Type Subtype PubMed ID
dgv134n111 CNV deletion 26073780
esv3643371 CNV loss 21293372
esv3643372 CNV gain 21293372
nsv458321 CNV loss 19166990
nsv470101 CNV loss 18288195
nsv578167 CNV loss 21841781
nsv828353 CNV loss 20364138
nsv828354 CNV gain 20364138
nsv953938 CNV deletion 24416366

Relevant External Links for MIR4745 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4745

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4745 Gene

Disorders for MIR4745 Gene

Relevant External Links for MIR4745

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4745

No disorders were found for MIR4745 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4745 Gene

Publications for MIR4745 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4745 Gene

Sources for MIR4745 Gene

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