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Aliases for MIR4745 Gene

Subcategory (RNA class) for MIR4745 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4745 Gene

  • MicroRNA 4745 2 3
  • PTBP1 4 5
  • Heterogeneous Nuclear Ribonucleoprotein I 4
  • Polypyrimidine Tract Binding Protein 1 5
  • 57 KDa RNA-Binding Protein PPTB-1 4
  • Hsa-Mir-4745 3
  • Mir-4745 3
  • HnRNP I 4
  • PTB 4

External Ids for MIR4745 Gene

Previous GeneCards Identifiers for MIR4745 Gene

  • GC19U901548
  • GC19P000809
  • GC19P000815
  • GC19P000806

Summaries for MIR4745 Gene

Entrez Gene Summary for MIR4745 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4745 Gene

MIR4745 (MicroRNA 4745) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is PTBP3.

UniProtKB/Swiss-Prot for MIR4745 Gene

  • Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4745 Gene

Genomics for MIR4745 Gene

Regulatory Elements for MIR4745 Gene

Enhancers for MIR4745 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR4745 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4745 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR4745 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4745 Gene

Chromosome:
19
Start:
797,075 bp from pter
End:
812,327 bp from pter
Size:
15,253 bases
Orientation:
Plus strand

Genomic View for MIR4745 Gene

Genes around MIR4745 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4745 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4745 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4745 Gene

Proteins for MIR4745 Gene

  • Protein details for MIR4745 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26599-PTBP1_HUMAN
    Recommended name:
    Polypyrimidine tract-binding protein 1
    Protein Accession:
    P26599
    Secondary Accessions:
    • Q9BUQ0

    Protein attributes for MIR4745 Gene

    Size:
    531 amino acids
    Molecular mass:
    57221 Da
    Quaternary structure:
    • Monomer. Part of a ternary complex containing KHSRP, PTBP1, PTBP2 and HNRPH1. Interacts with RAVER1 and SFPQ.
    • Monomer. Part of a ternary complex containing KHSRP, PTBP1, PTBP2 and HNRPH1. Interacts with RAVER1 and SFPQ.

    Three dimensional structures from OCA and Proteopedia for MIR4745 Gene

    Alternative splice isoforms for MIR4745 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR4745 Gene

Post-translational modifications for MIR4745 Gene

  • Ubiquitination at Lys 13, Lys 134, Lys 218, Lys 410, Lys 428, Lys 482, and Lys 485
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MIR4745 Gene

Domains & Families for MIR4745 Gene

Gene Families for MIR4745 Gene

Protein Domains for MIR4745 Gene

Graphical View of Domain Structure for InterPro Entry

P26599

UniProtKB/Swiss-Prot:

PTBP1_HUMAN :
  • Contains 4 RRM (RNA recognition motif) domains.
Domain:
  • Contains 4 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with MIR4745: view

No data available for Suggested Antigen Peptide Sequences for MIR4745 Gene

Function for MIR4745 Gene

Molecular function for MIR4745 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806).

Gene Ontology (GO) - Molecular Function for MIR4745 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS --
GO:0005515 protein binding IPI --
GO:0008187 poly-pyrimidine tract binding TAS --
GO:0036002 pre-mRNA binding IDA --
GO:0044822 poly(A) RNA binding IDA --
genes like me logo Genes that share ontologies with MIR4745: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4745 Gene

Localization for MIR4745 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4745 Gene

Gene Ontology (GO) - Cellular Components for MIR4745 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus TAS --
GO:0016020 membrane IDA --
GO:0070062 extracellular exosome IDA --
genes like me logo Genes that share ontologies with MIR4745: view

No data available for Subcellular locations from COMPARTMENTS for MIR4745 Gene

Pathways & Interactions for MIR4745 Gene

SuperPathways for MIR4745 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4745 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000380 alternative mRNA splicing, via spliceosome IEA --
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA --
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing TAS --
GO:0008380 RNA splicing TAS --
genes like me logo Genes that share ontologies with MIR4745: view

No data available for Pathways by source and SIGNOR curated interactions for MIR4745 Gene

Drugs & Compounds for MIR4745 Gene

No Compound Related Data Available

Transcripts for MIR4745 Gene

mRNA/cDNA for MIR4745 Gene

(22) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4745 Gene

No ASD Table

Relevant External Links for MIR4745 Gene

GeneLoc Exon Structure for
MIR4745
ECgene alternative splicing isoforms for
MIR4745

Expression for MIR4745 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4745 Gene:

MIR4745
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4745 Gene

Orthologs for MIR4745 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR4745 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTBP1 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTBP1 35
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTBP1 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptbp1 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTBP1 35
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTBP1 35
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTBP1 35
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTBP1 35
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ptbp1a 35
  • 78 (a)
OneToMany
ptbp1b 35
  • 76 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta heph 35
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ptb-1 35
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToMany
Species where no ortholog for MIR4745 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR4745 Gene

ENSEMBL:
Gene Tree for MIR4745 (if available)
TreeFam:
Gene Tree for MIR4745 (if available)

Paralogs for MIR4745 Gene

Paralogs for MIR4745 Gene

Pseudogenes.org Pseudogenes for MIR4745 Gene

genes like me logo Genes that share paralogs with MIR4745: view

Variants for MIR4745 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4745 Gene

Variant ID Type Subtype PubMed ID
dgv134n111 CNV deletion 26073780
esv3643371 CNV loss 21293372
esv3643372 CNV gain 21293372
nsv458321 CNV loss 19166990
nsv470101 CNV loss 18288195
nsv578167 CNV loss 21841781
nsv828353 CNV loss 20364138
nsv828354 CNV gain 20364138
nsv953938 CNV deletion 24416366

Relevant External Links for MIR4745 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4745

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR4745 Gene

Disorders for MIR4745 Gene

Relevant External Links for MIR4745

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4745

No disorders were found for MIR4745 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4745 Gene

Publications for MIR4745 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 65
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  4. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PMID: 22223895) Bienvenut W.V. … Giglione C. (Mol. Cell Proteomics 2012) 4 65
  5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 65

Products for MIR4745 Gene

Sources for MIR4745 Gene

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