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Aliases for MIR4741 Gene

Subcategory (RNA class) for MIR4741 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4741 Gene

  • MicroRNA 4741 2 3 5
  • Hsa-Mir-4741 3
  • Mir-4741 3

External Ids for MIR4741 Gene

Previous GeneCards Identifiers for MIR4741 Gene

  • GC18U900669
  • GC18P020516
  • GC18P022799

Summaries for MIR4741 Gene

Entrez Gene Summary for MIR4741 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4741 Gene

MIR4741 (MicroRNA 4741) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4741 include Seckel Syndrome 2 and Jawad Syndrome. Among its related pathways are DNA Double-Strand Break Repair and Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4741 Gene

Genomics for MIR4741 Gene

Regulatory Elements for MIR4741 Gene

Enhancers for MIR4741 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G022930 0.7 ENCODE 0.7 -3.0 -3047 0.2 CTCF ZNF654 TRIM22 REST RAD21 KAT8 ARID3A JUND HMBOX1 SMC3 LOC101927571 GC18M022924 MIR4741
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4741 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4741 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000101344 251 2001 PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF143 KLF13 SP5 ZHX2

Genomic Location for MIR4741 Gene

Chromosome:
18
Start:
22,933,349 bp from pter
End:
22,933,438 bp from pter
Size:
90 bases
Orientation:
Plus strand

Genomic View for MIR4741 Gene

Genes around MIR4741 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4741 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4741 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4741 Gene

Proteins for MIR4741 Gene

Post-translational modifications for MIR4741 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4741 Gene

Domains & Families for MIR4741 Gene

Gene Families for MIR4741 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4741: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4741 Gene

Function for MIR4741 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4741 Gene

Localization for MIR4741 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4741 Gene

Pathways & Interactions for MIR4741 Gene

genes like me logo Genes that share pathways with MIR4741: view

Pathways by source for MIR4741 Gene

Interacting Proteins for MIR4741 Gene

Gene Ontology (GO) - Biological Process for MIR4741 Gene

None

No data available for SIGNOR curated interactions for MIR4741 Gene

Drugs & Compounds for MIR4741 Gene

No Compound Related Data Available

Transcripts for MIR4741 Gene

mRNA/cDNA for MIR4741 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4741 Gene

No ASD Table

Relevant External Links for MIR4741 Gene

GeneLoc Exon Structure for
MIR4741
ECgene alternative splicing isoforms for
MIR4741

Expression for MIR4741 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4741 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4741 Gene:

MIR4741
genes like me logo Genes that share expression patterns with MIR4741: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4741 Gene

Orthologs for MIR4741 Gene

Evolution for MIR4741 Gene

ENSEMBL:
Gene Tree for MIR4741 (if available)
TreeFam:
Gene Tree for MIR4741 (if available)

No data available for Orthologs for MIR4741 Gene

Paralogs for MIR4741 Gene

No data available for Paralogs for MIR4741 Gene

Variants for MIR4741 Gene

Sequence variations from dbSNP and Humsavar for MIR4741 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs116097101 Likely benign 22,933,469(+) AAGGG(C/T)GAAAG intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs7244973 Likely benign 22,933,375(+) cctcc(A/G)agccc intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs115479920 Uncertain significance 22,933,413(+) GGGCT(A/G)TCCGG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs144559748 Uncertain significance 22,933,529(+) CTTCG(A/G)GGGCT intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs529532376 Uncertain significance 22,933,483(+) AAAGC(A/G)AGCAG intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime

Relevant External Links for MIR4741 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4741

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR4741 Gene

Disorders for MIR4741 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR4741 Gene - From: GeneCards

Disorder Aliases PubMed IDs
seckel syndrome 2
  • seckel syndrome type 2
jawad syndrome
  • microcephaly with mental retardation and digital anomalies
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR4741

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4741
genes like me logo Genes that share disorders with MIR4741: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR4741 Gene

Publications for MIR4741 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4741 Gene

Sources for MIR4741 Gene

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