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Aliases for MIR4740 Gene

Subcategory (RNA class) for MIR4740 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4740 Gene

  • MicroRNA 4740 2 3 5
  • Hsa-Mir-4740 3

External Ids for MIR4740 Gene

Previous GeneCards Identifiers for MIR4740 Gene

  • GC17U901640
  • GC02M109931
  • GC17M079377

Summaries for MIR4740 Gene

Entrez Gene Summary for MIR4740 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4740 Gene

MIR4740 (MicroRNA 4740) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4740 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4740 Gene

Genomics for MIR4740 Gene

Regulatory Elements for MIR4740 Gene

Enhancers for MIR4740 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H081416 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -19.8 -19757 7 SIN3A FEZF1 GLIS2 FOS KLF7 DEK SP3 SMARCB1 GLIS1 STAT3 HGS MAFG FSCN2 CCDC137 NPLOC4 MIR4740 GC17M081444
GH17H081412 1.4 Ensembl ENCODE dbSUPER 0.4 -12.1 -12129 1 HDAC1 ATF1 KLF17 ZBTB40 TCF12 ZNF766 EGR1 ETV6 ATF7 RUNX3 MIR4740 GC17M081444
GH17H081409 1.1 ENCODE dbSUPER 0.4 -8.5 -8548 0 HDAC1 PKNOX1 ARNT EGR1 CREM ZBTB2 REST ZNF592 TFDP1 SMARCA4 MIR4740 GC17M081444
GH17H081424 1.2 ENCODE dbSUPER 0.3 -24.0 -23998 0 HDGF YBX1 PLRG1 ZBTB7B ZNF155 YY2 ZNF114 ZIK1 ZNF488 ZNF662 OGFOD3 FAAP100 CEP131 ENSG00000262877 TEPSIN ENSG00000265678 HEXDC HGS ENSG00000260563 ENSG00000260369
GH17H081435 1.2 Ensembl ENCODE dbSUPER 0.3 -35.9 -35867 3 TBP KLF1 ZIC2 ZNF2 BCL11B ZFHX2 GLIS2 EGR1 PATZ1 SCRT2 ENSG00000262877 GC17M081444 MIR4740
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4740 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4740 Gene

Chromosome:
17
Start:
81,400,716 bp from pter
End:
81,400,778 bp from pter
Size:
63 bases
Orientation:
Minus strand

Genomic View for MIR4740 Gene

Genes around MIR4740 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4740 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4740 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4740 Gene

ORGUL Member Location for MIR4740 Gene

ORGUL Member Location for MIR4740 gene

Proteins for MIR4740 Gene

Post-translational modifications for MIR4740 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4740 Gene

Domains & Families for MIR4740 Gene

Gene Families for MIR4740 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4740: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4740 Gene

Function for MIR4740 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR4740
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4740 Gene

Localization for MIR4740 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4740 Gene

Pathways & Interactions for MIR4740 Gene

SuperPathways for MIR4740 Gene

No Data Available

Interacting Proteins for MIR4740 Gene

Gene Ontology (GO) - Biological Process for MIR4740 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4740 Gene

Drugs & Compounds for MIR4740 Gene

No Compound Related Data Available

Transcripts for MIR4740 Gene

mRNA/cDNA for MIR4740 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR4740
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4740 Gene

No ASD Table

Relevant External Links for MIR4740 Gene

GeneLoc Exon Structure for
MIR4740
ECgene alternative splicing isoforms for
MIR4740

Expression for MIR4740 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4740 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4740 Gene:

MIR4740
genes like me logo Genes that share expression patterns with MIR4740: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4740 Gene

Orthologs for MIR4740 Gene

Evolution for MIR4740 Gene

ENSEMBL:
Gene Tree for MIR4740 (if available)
TreeFam:
Gene Tree for MIR4740 (if available)

No data available for Orthologs for MIR4740 Gene

Paralogs for MIR4740 Gene

No data available for Paralogs for MIR4740 Gene

Variants for MIR4740 Gene

Sequence variations from dbSNP and Humsavar for MIR4740 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000218577 -- 81,402,468(+) ATTTT(C/T)TTGCG intron-variant, upstream-variant-2KB
rs1000569156 -- 81,402,306(+) AAAGC(C/T)TTTTG intron-variant, upstream-variant-2KB
rs1001725724 -- 81,402,767(+) GCTGC(C/T)GGGGC intron-variant, upstream-variant-2KB
rs1002007296 -- 81,401,577(+) GCCGC(C/T)CTGGC intron-variant, upstream-variant-2KB
rs1002073239 -- 81,402,527(+) TTTTC(C/T)TGGAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4740 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV gain+loss 19812545
nsv428351 CNV gain 18775914
nsv576173 CNV loss 21841781
nsv576174 CNV loss 21841781
nsv576175 CNV loss 21841781
nsv828128 CNV loss 20364138
nsv828134 CNV loss 20364138
nsv952389 CNV deletion 24416366

Relevant External Links for MIR4740 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4740

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4740 Gene

Disorders for MIR4740 Gene

Relevant External Links for MIR4740

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4740

No disorders were found for MIR4740 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4740 Gene

Publications for MIR4740 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 60
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR4740 Gene

Sources for MIR4740 Gene

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