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Aliases for MIR4740 Gene

Subcategory (RNA class) for MIR4740 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4740 Gene

  • MicroRNA 4740 2 3 5
  • Hsa-Mir-4740 3

External Ids for MIR4740 Gene

Previous GeneCards Identifiers for MIR4740 Gene

  • GC17U901640
  • GC02M109931
  • GC17M079377

Summaries for MIR4740 Gene

Entrez Gene Summary for MIR4740 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4740 Gene

MIR4740 (MicroRNA 4740) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4740 Gene

Genomics for MIR4740 Gene

Regulatory Elements for MIR4740 Gene

Enhancers for MIR4740 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F081409 0.5 ENCODE 0.4 -8.5 -8548 0.1 CTCF KLF1 CBX3 TAL1 NCOR1 PATZ1 E2F6 CREM RFX1 L3MBTL2 MIR4740 GC17M081444
GH17F081410 0.2 Ensembl 0.4 -8.8 -8823 0.4 CTCF KLF1 CBX3 TAL1 KLF17 NCOR1 PATZ1 E2F6 CREM RFX1 ENSG00000262877 MIR4740 GC17M081444
GH17F081411 1.1 Ensembl ENCODE 0.4 -11.6 -11623 2.8 HDAC1 ATF1 CBX3 KLF17 ZBTB40 GLIS2 EGR1 ZNF366 SCRT2 ETV6 ENSG00000262877 ACTG1 MIR4740 GC17M081444
GH17F081416 1.4 FANTOM5 Ensembl ENCODE 0.3 -19.9 -19892 7.9 HDGF SIN3A GLI4 YBX1 FEZF1 ZNF2 GLIS2 ZNF143 KLF7 FOS ENSG00000262877 MCRIP1 MAFG FSCN2 CCDC137 HGS NPLOC4 MIR4740 GC17M081444
GH17F081426 0.2 Ensembl 0.3 -25.7 -25723 0.2 GC17M081444 MIR4740
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4740 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4740 Gene

Chromosome:
17
Start:
81,400,716 bp from pter
End:
81,400,778 bp from pter
Size:
63 bases
Orientation:
Minus strand

Genomic View for MIR4740 Gene

Genes around MIR4740 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4740 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4740 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4740 Gene

ORGUL Member Location for MIR4740 Gene

ORGUL Member Location for MIR4740 gene

Proteins for MIR4740 Gene

Post-translational modifications for MIR4740 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4740 Gene

Domains & Families for MIR4740 Gene

Gene Families for MIR4740 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4740: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4740 Gene

Function for MIR4740 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4740 Gene

Localization for MIR4740 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4740 Gene

Pathways & Interactions for MIR4740 Gene

SuperPathways for MIR4740 Gene

No Data Available

Interacting Proteins for MIR4740 Gene

Gene Ontology (GO) - Biological Process for MIR4740 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4740 Gene

Transcripts for MIR4740 Gene

mRNA/cDNA for MIR4740 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4740 Gene

No ASD Table

Relevant External Links for MIR4740 Gene

GeneLoc Exon Structure for
MIR4740
ECgene alternative splicing isoforms for
MIR4740

Expression for MIR4740 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4740 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4740 Gene:

MIR4740
genes like me logo Genes that share expression patterns with MIR4740: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4740 Gene

Orthologs for MIR4740 Gene

Evolution for MIR4740 Gene

ENSEMBL:
Gene Tree for MIR4740 (if available)
TreeFam:
Gene Tree for MIR4740 (if available)

No data available for Orthologs for MIR4740 Gene

Paralogs for MIR4740 Gene

No data available for Paralogs for MIR4740 Gene

Variants for MIR4740 Gene

Sequence variations from dbSNP and Humsavar for MIR4740 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10664154 -- 81,401,825(+) CAGCA(-/CT)CTCTC intron-variant, upstream-variant-2KB
rs111290549 -- 81,402,372(+) TTTTT(A/T)AAAAA intron-variant, upstream-variant-2KB
rs111536253 -- 81,401,559(+) CGGGG(C/G)GCTGA intron-variant, upstream-variant-2KB
rs112459964 -- 81,400,407(+) TGCTG(A/G)TGTAA intron-variant, downstream-variant-500B
rs11649911 -- 81,400,500(+) TGCCT(C/G)TGGTA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR4740 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV gain+loss 19812545
nsv428351 CNV gain 18775914
nsv576173 CNV loss 21841781
nsv576174 CNV loss 21841781
nsv576175 CNV loss 21841781
nsv828128 CNV loss 20364138
nsv828134 CNV loss 20364138
nsv952389 CNV deletion 24416366

Relevant External Links for MIR4740 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4740

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4740 Gene

Disorders for MIR4740 Gene

Relevant External Links for MIR4740

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4740

No disorders were found for MIR4740 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4740 Gene

Publications for MIR4740 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4740 Gene

Sources for MIR4740 Gene

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