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Aliases for MIR4738 Gene

Subcategory (RNA class) for MIR4738 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4738 Gene

  • MicroRNA 4738 2 3
  • H3 Histone, Family 3B (H3.3B) 5
  • Hsa-Mir-4738 3
  • H3F3A H3F3B 4
  • H3.3A 4
  • H3.3B 4
  • H3F3B 5
  • H3F3 4

External Ids for MIR4738 Gene

Previous GeneCards Identifiers for MIR4738 Gene

  • GC17U901645
  • GC17M073784
  • GC17M075784

Summaries for MIR4738 Gene

Entrez Gene Summary for MIR4738 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4738 Gene

MIR4738 (MicroRNA 4738) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is H3F3A.

UniProtKB/Swiss-Prot for MIR4738 Gene

  • Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4738 Gene

Genomics for MIR4738 Gene

Regulatory Elements for MIR4738 Gene

Enhancers for MIR4738 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR4738 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4738 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR4738 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4738 Gene

Chromosome:
17
Start:
75,776,434 bp from pter
End:
75,785,893 bp from pter
Size:
9,460 bases
Orientation:
Minus strand

Genomic View for MIR4738 Gene

Genes around MIR4738 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4738 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4738 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4738 Gene

ORGUL Member Location for MIR4738 Gene

ORGUL Member Location for MIR4738 gene

Proteins for MIR4738 Gene

  • Protein details for MIR4738 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P84243-H33_HUMAN
    Recommended name:
    Histone H3.3
    Protein Accession:
    P84243
    Secondary Accessions:
    • P06351
    • P33155
    • Q5VV55
    • Q5VV56
    • Q66I33
    • Q9V3W4

    Protein attributes for MIR4738 Gene

    Size:
    136 amino acids
    Molecular mass:
    15328 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HIRA, a chaperone required for its incorporation into nucleosomes. Interacts with ZMYND11; when trimethylated at Lys-36 (H3.3K36me3).
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HIRA, a chaperone required for its incorporation into nucleosomes. Interacts with ZMYND11; when trimethylated at Lys-36 (H3.3K36me3).
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HIRA, a chaperone required for its incorporation into nucleosomes. Interacts with ZMYND11; when trimethylated at Lys-36 (H3.3K36me3).
    SequenceCaution:
    • Sequence=CAH73371.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MIR4738 Gene

neXtProt entry for MIR4738 Gene

Post-translational modifications for MIR4738 Gene

  • Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
  • Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3 of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.
  • Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (PubMed:22483618).
  • Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes.
  • Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 and Lys-80. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me), which are linked to gene repression, are underrepresented. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at Lys-120. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication.
  • Ubiquitinated. Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity).
  • Ubiquitination at Lys 116
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MIR4738 Gene

Domains & Families for MIR4738 Gene

Gene Families for MIR4738 Gene

Protein Domains for MIR4738 Gene

Graphical View of Domain Structure for InterPro Entry

P84243

UniProtKB/Swiss-Prot:

H33_HUMAN :
  • Specific interaction of trimethylated form at Lys-36 (H3.3K36me3) with ZMYND11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains.
  • Belongs to the histone H3 family.
Domain:
  • Specific interaction of trimethylated form at Lys-36 (H3.3K36me3) with ZMYND11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains.
Family:
  • Belongs to the histone H3 family.
genes like me logo Genes that share domains with MIR4738: view

No data available for Suggested Antigen Peptide Sequences for MIR4738 Gene

Function for MIR4738 Gene

Molecular function for MIR4738 Gene

UniProtKB/Swiss-Prot Function:
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Ontology (GO) - Molecular Function for MIR4738 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA --
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA --
GO:0005515 protein binding IPI --
GO:0031492 nucleosomal DNA binding IDA --
GO:0042393 histone binding IPI --
genes like me logo Genes that share ontologies with MIR4738: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4738 Gene

Localization for MIR4738 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4738 Gene

Gene Ontology (GO) - Cellular Components for MIR4738 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA --
GO:0000784 nuclear chromosome, telomeric region IDA --
GO:0000786 nucleosome IDA --
GO:0000788 nuclear nucleosome IDA --
GO:0001740 Barr body IEA --
genes like me logo Genes that share ontologies with MIR4738: view

No data available for Subcellular locations from COMPARTMENTS for MIR4738 Gene

Pathways & Interactions for MIR4738 Gene

SuperPathways for MIR4738 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4738 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IEA --
GO:0006334 nucleosome assembly IMP --
GO:0006336 DNA replication-independent nucleosome assembly IDA --
GO:0006997 nucleus organization IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with MIR4738: view

No data available for Pathways by source and SIGNOR curated interactions for MIR4738 Gene

Drugs & Compounds for MIR4738 Gene

No Compound Related Data Available

Transcripts for MIR4738 Gene

mRNA/cDNA for MIR4738 Gene

(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4738 Gene

No ASD Table

Relevant External Links for MIR4738 Gene

GeneLoc Exon Structure for
MIR4738
ECgene alternative splicing isoforms for
MIR4738

Expression for MIR4738 Gene

mRNA expression in normal human tissues for MIR4738 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4738 Gene:

MIR4738
genes like me logo Genes that share expression patterns with MIR4738: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4738 Gene

Orthologs for MIR4738 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR4738 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia H3F3A 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia H3F3B 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia H3F3B 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia H3f3a 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia H3F3B 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia H3F3C 35
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves H3-IX 35
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 100 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii h3f3a 35
  • 100 (a)
OneToMany
H3F3B (1 of 3) 35
  • 100 (a)
OneToMany
H3F3B (3 of 3) 35
  • 100 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta His3.3A 35
  • 100 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea his-71 35
  • 99 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HHT1 35
  • 90 (a)
ManyToMany
HHT2 35
  • 90 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1064 35
  • 100 (a)
OneToOne
Species where no ortholog for MIR4738 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR4738 Gene

ENSEMBL:
Gene Tree for MIR4738 (if available)
TreeFam:
Gene Tree for MIR4738 (if available)

Paralogs for MIR4738 Gene

genes like me logo Genes that share paralogs with MIR4738: view

Variants for MIR4738 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4738 Gene

Variant ID Type Subtype PubMed ID
nsv470606 CNV loss 18288195
nsv833545 CNV gain 17160897

Relevant External Links for MIR4738 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4738

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR4738 Gene

Disorders for MIR4738 Gene

Relevant External Links for MIR4738

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4738

No disorders were found for MIR4738 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4738 Gene

Publications for MIR4738 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 65
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65
  3. ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression. (PMID: 24590075) Wen H. … Shi X. (Nature 2014) 4 65
  4. Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer. (PMID: 23415232) Tropberger P. … Schneider R. (Cell 2013) 4 65
  5. Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA. (PMID: 22387026) Yu Y. … Grunstein M. (Mol. Cell 2012) 4 65

Products for MIR4738 Gene

Sources for MIR4738 Gene

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