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Aliases for MIR4733 Gene

Subcategory (RNA class) for MIR4733 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4733 Gene

  • MicroRNA 4733 2 3 5
  • Hsa-Mir-4733 3

External Ids for MIR4733 Gene

Previous GeneCards Identifiers for MIR4733 Gene

  • GC17U901634
  • GC17M029425

Summaries for MIR4733 Gene

Entrez Gene Summary for MIR4733 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4733 Gene

MIR4733 (MicroRNA 4733) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4733 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4733 Gene

Genomics for MIR4733 Gene

GeneHancer (GH) Regulatory Elements for MIR4733 Gene

Promoters and enhancers for MIR4733 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I031093 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.9 -889 2.8 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF213 FOS LOC105371722 MIR4733 NF1 ENSG00000264456 RNF135 SUZ12 UTP6 SH3GL1P2 SH3GL1P1 ATAD5
GH17I031066 Enhancer 0.9 Ensembl ENCODE 0.3 +26.4 26400 2.3 CTCF JUN RAD21 FOSL1 GATA3 ZNF143 FOSL2 FOS ZNF654 CEBPB RAB11FIP4 ATAD5 RPS17P3 LOC101927093 LOC646030 MIR4733 ENSG00000266865 NF1
GH17I031085 Enhancer 0.6 Ensembl 0.4 +8.6 8625 0.4 CBFA2T3 DPF2 FOSL1 ATF4 ZNF766 JUND SMARCA4 HMBOX1 PRDM10 FOS MIR4733 LOC646030 NF1 ENSG00000266865
GH17I031074 Enhancer 0.6 ENCODE 0.4 +19.5 19457 1.2 ZNF449 ZNF384 ZIC2 SP1 ZNF335 SCRT2 GLIS1 ZBTB17 ZNF558 ENSG00000264148 MIR4733 LOC646030 NF1 ENSG00000266865
GH17I031071 Enhancer 0.8 ENCODE 0.3 +22.2 22224 2 NCOA3 INSM2 NEUROD1 FEZF1 CEBPG ZNF507 ZEB1 ZFHX2 CTBP1 GATA3 OMG LOC646030 MIR4733 NF1 ENSG00000266865
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4733 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4733 Gene

Genomic Locations for MIR4733 Gene
chr17:31,094,350-31,094,425
(GRCh38/hg38)
Size:
76 bases
Orientation:
Minus strand
chr17:29,421,368-29,421,443
(GRCh37/hg19)

Genomic View for MIR4733 Gene

Genes around MIR4733 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4733 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4733 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4733 Gene

Proteins for MIR4733 Gene

Post-translational modifications for MIR4733 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4733 Gene

Domains & Families for MIR4733 Gene

Gene Families for MIR4733 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4733: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4733 Gene

Function for MIR4733 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4733 Gene

Localization for MIR4733 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4733 Gene

Pathways & Interactions for MIR4733 Gene

SuperPathways for MIR4733 Gene

No Data Available

Interacting Proteins for MIR4733 Gene

Gene Ontology (GO) - Biological Process for MIR4733 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4733 Gene

Drugs & Compounds for MIR4733 Gene

No Compound Related Data Available

Transcripts for MIR4733 Gene

mRNA/cDNA for MIR4733 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4733 Gene

No ASD Table

Relevant External Links for MIR4733 Gene

GeneLoc Exon Structure for
MIR4733
ECgene alternative splicing isoforms for
MIR4733

Expression for MIR4733 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4733 Gene:

MIR4733
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4733 Gene

Orthologs for MIR4733 Gene

Evolution for MIR4733 Gene

ENSEMBL:
Gene Tree for MIR4733 (if available)
TreeFam:
Gene Tree for MIR4733 (if available)

No data available for Orthologs for MIR4733 Gene

Paralogs for MIR4733 Gene

No data available for Paralogs for MIR4733 Gene

Variants for MIR4733 Gene

Sequence variations from dbSNP and Humsavar for MIR4733 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1057516197 likely-pathogenic, Neurofibromatosis, type 1 31,095,323(-) GG/G upstream_transcript_variant
rs1060500252 pathogenic, Neurofibromatosis, type 1 31,095,310(-) A/G upstream_transcript_variant
rs1060500261 uncertain-significance, Neurofibromatosis, type 1 31,095,346(-) G/A upstream_transcript_variant
rs1060503895 likely-benign, Neurofibromatosis, type 1 31,095,376(-) G/C upstream_transcript_variant
rs556823296 likely-benign, not specified, Neurofibromatosis, familial spinal, Neurofibromatosis-Noonan syndrome, Caf\u00e9-au-lait macules with pulmonary stenosis, Neurofibromatosis, type 1 31,095,288(-) G/C upstream_transcript_variant

Additional Variant Information for MIR4733 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4733

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR4733 Gene

Disorders for MIR4733 Gene

Additional Disease Information for MIR4733

No disorders were found for MIR4733 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4733 Gene

Publications for MIR4733 Gene

  1. TAGLN expression is upregulated in NF1-associated malignant peripheral nerve sheath tumors by hypomethylation in its promoter and subpromoter regions. (PMID: 25109740) Park GH … Jeong SY (Oncology reports 2014) 3 58
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4733 Gene

Sources for MIR4733 Gene

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