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Aliases for MIR4728 Gene

Subcategory (RNA class) for MIR4728 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4728 Gene

  • MicroRNA 4728 2 3 5
  • Hsa-Mir-4728 3

External Ids for MIR4728 Gene

Previous GeneCards Identifiers for MIR4728 Gene

  • GC17U901661
  • GC17P037885

Summaries for MIR4728 Gene

Entrez Gene Summary for MIR4728 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4728 Gene

MIR4728 (MicroRNA 4728) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4728 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4728 Gene

Genomics for MIR4728 Gene

GeneHancer (GH) Regulatory Elements for MIR4728 Gene

Promoters and enhancers for MIR4728 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I039728 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 0.8 +3.5 3503 2.4 MLX ARID4B SIN3A ZNF2 SLC30A9 POLR2B E2F8 ZNF207 ZNF143 KLF13 MIEN1 SNORD124 GSDMA ORMDL3 GSDMB MIR4728 ERBB2
GH17I039698 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.3 -23.1 -23121 8.8 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZBTB7B YY1 FOS SP3 SP5 ERBB2 GRB7 PGAP3 MIEN1 NEUROD2 THRA ORMDL3 GSDMB MIR4728
GH17I039723 Enhancer 1 ENCODE dbSUPER 0.8 -2.9 -2854 0.7 HDAC1 HDGF TAF9B ZBTB40 POLR2B GLIS2 EGR1 ATF7 CREM EGR2 PGAP3 MIR4728 ERBB2
GH17I039719 Enhancer 0.5 dbSUPER 0.4 -6.7 -6721 1 ZFHX2 KLF1 ZNF449 KLF17 EGR2 PGAP3 MIR4728 ERBB2
GH17I039715 Enhancer 0.5 dbSUPER 0.4 -10.1 -10128 2.6 ZNF263 POLR2A HNF4A NFXL1 RAD21 GRB7 ERBB2 NEUROD2 MIR4728 PGAP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4728 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4728 Gene

Genomic Locations for MIR4728 Gene
chr17:39,726,495-39,726,561
(GRCh38/hg38)
Size:
67 bases
Orientation:
Plus strand
chr17:37,882,732-37,882,819
(GRCh37/hg19)

Genomic View for MIR4728 Gene

Genes around MIR4728 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4728 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4728 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4728 Gene

Proteins for MIR4728 Gene

Post-translational modifications for MIR4728 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4728 Gene

Domains & Families for MIR4728 Gene

Gene Families for MIR4728 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4728: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4728 Gene

Function for MIR4728 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4728 Gene

Localization for MIR4728 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4728 Gene

Pathways & Interactions for MIR4728 Gene

SuperPathways for MIR4728 Gene

No Data Available

Interacting Proteins for MIR4728 Gene

Gene Ontology (GO) - Biological Process for MIR4728 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4728 Gene

Drugs & Compounds for MIR4728 Gene

No Compound Related Data Available

Transcripts for MIR4728 Gene

mRNA/cDNA for MIR4728 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4728 Gene

No ASD Table

Relevant External Links for MIR4728 Gene

GeneLoc Exon Structure for
MIR4728
ECgene alternative splicing isoforms for
MIR4728

Expression for MIR4728 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4728 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4728 Gene:

MIR4728
genes like me logo Genes that share expression patterns with MIR4728: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4728 Gene

Orthologs for MIR4728 Gene

Evolution for MIR4728 Gene

ENSEMBL:
Gene Tree for MIR4728 (if available)
TreeFam:
Gene Tree for MIR4728 (if available)

No data available for Orthologs for MIR4728 Gene

Paralogs for MIR4728 Gene

No data available for Paralogs for MIR4728 Gene

Variants for MIR4728 Gene

Sequence variations from dbSNP and Humsavar for MIR4728 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs104886007 not-provided, Familial cancer of breast 39,725,046(+) C/T upstream_transcript_variant
rs104886008 not-provided, Endometrial carcinoma 39,725,061(+) C/T upstream_transcript_variant
rs104886009 not-provided, Familial cancer of breast 39,725,123(+) C/T upstream_transcript_variant
rs104886010 not-provided, Neoplasm of ovary 39,725,160(+) C/T upstream_transcript_variant
rs104886011 not-provided, Familial cancer of breast 39,725,075(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4728 Gene

Variant ID Type Subtype PubMed ID
dgv40n68 CNV loss 17160897
nsv1056234 CNV gain 25217958
nsv1146669 OTHER inversion 26484159
nsv2048 CNV insertion 18451855

Additional Variant Information for MIR4728 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4728

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4728 Gene

Disorders for MIR4728 Gene

Additional Disease Information for MIR4728

No disorders were found for MIR4728 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4728 Gene

Publications for MIR4728 Gene

  1. Significant impact of miRNA-target gene networks on genetics of human complex traits. (PMID: 26927695) Okada Y … Tanaka T (Scientific reports 2016) 3 58
  2. MiR-4728-3p could act as a marker of HER2 status. (PMID: 26406406) Li H … Liu P (Cancer biomarkers : section A of Disease markers 2015) 3 58
  3. ErbB2-intronic microRNA-4728: a novel tumor suppressor and antagonist of oncogenic MAPK signaling. (PMID: 25950472) Schmitt DC … Tan M (Cell death & disease 2015) 3 58
  4. The HER2-encoded miR-4728-3p regulates ESR1 through a non-canonical internal seed interaction. (PMID: 24828673) Newie I … Rovira C (PloS one 2014) 3 58
  5. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 58

Products for MIR4728 Gene

Sources for MIR4728 Gene

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