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Aliases for MIR4728 Gene

Subcategory (RNA class) for MIR4728 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4728 Gene

  • MicroRNA 4728 2 3 5
  • Hsa-Mir-4728 3

External Ids for MIR4728 Gene

Previous GeneCards Identifiers for MIR4728 Gene

  • GC17U901661
  • GC17P037885

Summaries for MIR4728 Gene

Entrez Gene Summary for MIR4728 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4728 Gene

MIR4728 (MicroRNA 4728) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4728 Gene

Genomics for MIR4728 Gene

Regulatory Elements for MIR4728 Gene

Enhancers for MIR4728 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G039723 1.1 ENCODE dbSUPER 0.7 -2.9 -2854 0.7 HDAC1 TBP HDGF ZBTB40 GLIS2 EGR1 KLF13 CREM EGR2 SP3 PGAP3 MIR4728
GH17G039728 1.1 ENCODE 0.7 +3.5 3503 2.4 HNRNPUL1 FOXA2 MLX AGO1 ARID4B SIN3A ZNF2 SLC30A9 ZNF766 ZNF143 SNORD124 GSDMA ORMDL3 GSDMB MIEN1 MIR4728
GH17G039698 1.9 FANTOM5 Ensembl ENCODE dbSUPER 0.3 -23.1 -23122 8.8 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZBTB7B YY1 FOS ZNF263 SP3 GRB7 PGAP3 MIEN1 NEUROD2 ERBB2 THRA ORMDL3 GSDMB MIR4728
GH17G039715 0.6 dbSUPER 0.4 -10.1 -10128 2.6 ZNF263 ZNF10 HNF4A NFXL1 RAD21 HNRNPL GRB7 ERBB2 NEUROD2 MIR4728 PGAP3
GH17G039709 0.6 dbSUPER 0.4 -16.3 -16336 0.6 ZNF263 ZSCAN4 ATF2 HIC1 SMARCA4 POLR2A KLF16 HNRNPL MIEN1 GRB7 ERBB2 NEUROD2 PGAP3 MIR4728
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4728 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4728 Gene

Chromosome:
17
Start:
39,726,495 bp from pter
End:
39,726,561 bp from pter
Size:
67 bases
Orientation:
Plus strand

Genomic View for MIR4728 Gene

Genes around MIR4728 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4728 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4728 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4728 Gene

Proteins for MIR4728 Gene

Post-translational modifications for MIR4728 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4728 Gene

Domains & Families for MIR4728 Gene

Gene Families for MIR4728 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4728: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4728 Gene

Function for MIR4728 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4728 Gene

Localization for MIR4728 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4728 Gene

Pathways & Interactions for MIR4728 Gene

SuperPathways for MIR4728 Gene

No Data Available

Interacting Proteins for MIR4728 Gene

Gene Ontology (GO) - Biological Process for MIR4728 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4728 Gene

Drugs & Compounds for MIR4728 Gene

No Compound Related Data Available

Transcripts for MIR4728 Gene

mRNA/cDNA for MIR4728 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4728 Gene

No ASD Table

Relevant External Links for MIR4728 Gene

GeneLoc Exon Structure for
MIR4728
ECgene alternative splicing isoforms for
MIR4728

Expression for MIR4728 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4728 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4728 Gene:

MIR4728
genes like me logo Genes that share expression patterns with MIR4728: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4728 Gene

Orthologs for MIR4728 Gene

Evolution for MIR4728 Gene

ENSEMBL:
Gene Tree for MIR4728 (if available)
TreeFam:
Gene Tree for MIR4728 (if available)

No data available for Orthologs for MIR4728 Gene

Paralogs for MIR4728 Gene

No data available for Paralogs for MIR4728 Gene

Variants for MIR4728 Gene

Sequence variations from dbSNP and Humsavar for MIR4728 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs28933368 Pathogenic 39,725,721(+) TGTGG(A/G)AGCTG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs28933369 Pathogenic 39,724,744(+) TGGCT(A/G)GTGTG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs28933370 Pathogenic 39,725,125(+) TCCCA(A/G)CCATG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs397516975 Pathogenic 39,724,740(+) TGATG(-/GCATACGTGATG)GCTGG nc-transcript-variant, upstream-variant-2KB, cds-indel
rs397516976 Pathogenic 39,724,742(+) ATGGC(-/ATACGTGATGGC/CTCCGTGATGGC)TGGTG nc-transcript-variant, upstream-variant-2KB, cds-indel

Structural Variations from Database of Genomic Variants (DGV) for MIR4728 Gene

Variant ID Type Subtype PubMed ID
dgv40n68 CNV loss 17160897
nsv1056234 CNV gain 25217958
nsv1146669 OTHER inversion 26484159
nsv2048 CNV insertion 18451855

Relevant External Links for MIR4728 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4728

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4728 Gene

Disorders for MIR4728 Gene

Relevant External Links for MIR4728

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4728

No disorders were found for MIR4728 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4728 Gene

Publications for MIR4728 Gene

  1. Significant impact of miRNA-target gene networks on genetics of human complex traits. (PMID: 26927695) Okada Y. … Tanaka T. (Sci Rep 2016) 3 64
  2. MiR-4728-3p could act as a marker of HER2 status. (PMID: 26406406) Li H. … Liu P. (Cancer Biomark 2015) 3 64
  3. ErbB2-intronic microRNA-4728: a novel tumor suppressor and antagonist of oncogenic MAPK signaling. (PMID: 25950472) Schmitt D.C. … Tan M. (Cell Death Dis 2015) 3 64
  4. The HER2-encoded miR-4728-3p regulates ESR1 through a non-canonical internal seed interaction. (PMID: 24828673) Newie I. … Rovira C. (PLoS ONE 2014) 3 64
  5. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64

Products for MIR4728 Gene

Sources for MIR4728 Gene

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