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Aliases for MIR4724 Gene

Subcategory (RNA class) for MIR4724 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4724 Gene

  • MicroRNA 4724 2 3
  • RAB11FIP4 4 5
  • RAB11 Family Interacting Protein 4 5
  • Hsa-Mir-4724 3
  • Arfophilin-2 4
  • FIP4-Rab11 4
  • Rab11-FIP4 4
  • Mir-4724 3
  • KIAA1821 4
  • ARFO2 4

External Ids for MIR4724 Gene

Previous GeneCards Identifiers for MIR4724 Gene

  • GC17U901658
  • GC17P029865
  • GC17P031534

Summaries for MIR4724 Gene

Entrez Gene Summary for MIR4724 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4724 Gene

MIR4724 (MicroRNA 4724) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is RAB11FIP3.

UniProtKB/Swiss-Prot for MIR4724 Gene

  • Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an address tag delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4724 Gene

Genomics for MIR4724 Gene

Regulatory Elements for MIR4724 Gene

Enhancers for MIR4724 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F031486 1.4 FANTOM5 ENCODE 11.9 +100.1 100135 10.5 HDGF PKNOX1 ARID4B DMAP1 ZNF2 FOS SP3 SP5 NFYC JUNB RAB11FIP4 EVI2B ENSG00000266490 MIR4724 LRRC37B LOC105371722 SUZ12P1 EVI2A SUZ12 GC17P031509
GH17F031592 1.5 FANTOM5 Ensembl ENCODE 10.1 +204.7 204656 6.7 TBP PKNOX1 SIN3A ZNF48 RAD21 FOS JUNB CEBPB KAT8 IKZF1 RAB11FIP4 MIR193A RNU6ATAC7P MIR4724 RNF135 CRLF3 EVI2A ENSG00000266877 GC17M031638 PIR51917
GH17F031450 1.3 FANTOM5 Ensembl ENCODE 11.6 +60.4 60359 2.3 CTCF ESRRA JUN ZNF384 RAD21 GLIS2 CTBP1 ZNF366 EED SMC3 RAB11FIP4 MIR4724 RN7SL79P LOC105371725
GH17F031578 1.4 FANTOM5 Ensembl ENCODE 10.4 +189.3 189277 4.2 BCOR TBP ZNF146 CBX3 JUN ZMYM3 SIN3A ZIC2 RAD21 RFX5 MIR193A MIR4724 RAB11FIP4 EVI2A EVI2B ENSG00000266877 GC17M031575
GH17F031306 1.4 FANTOM5 ENCODE 10.3 -80.8 -80804 9.5 HDGF PKNOX1 ARNT CREB3L1 SIN3A FEZF1 ZNF2 YY1 ZNF143 FOS EVI2A UTP6 OMG MIR4724 RAB11FIP4 SUZ12 CRLF3 EVI2B ADAP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4724 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4724 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001806345 76 1001 SP3 KDM1A PRDM1 EZH2

Genomic Location for MIR4724 Gene

Chromosome:
17
Start:
31,391,624 bp from pter
End:
31,538,217 bp from pter
Size:
146,594 bases
Orientation:
Plus strand

Genomic View for MIR4724 Gene

Genes around MIR4724 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4724 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4724 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4724 Gene

Proteins for MIR4724 Gene

  • Protein details for MIR4724 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YS3-RFIP4_HUMAN
    Recommended name:
    Rab11 family-interacting protein 4
    Protein Accession:
    Q86YS3
    Secondary Accessions:
    • Q52LI1
    • Q8N829
    • Q8NDT7
    • Q969D8

    Protein attributes for MIR4724 Gene

    Size:
    637 amino acids
    Molecular mass:
    71928 Da
    Quaternary structure:
    • Homodimer. Forms a complex with Rab11 (RAB11A or RAB11B) and ARF6. Interacts with RAB11A; the interaction is direct. Forms a heterooligomeric complex with RAB11FIP2, RAB11FIP3 and RAB11FIP5. Interacts with HCMV (human cytomegalovirus) gM/UL100. Interacts with ECM29.
    • Homodimer. Forms a complex with Rab11 (RAB11A or RAB11B) and ARF6. Interacts with RAB11A; the interaction is direct. Forms a heterooligomeric complex with RAB11FIP2, RAB11FIP3 and RAB11FIP5. Interacts with HCMV (human cytomegalovirus) gM/UL100. Interacts with ECM29.

    Alternative splice isoforms for MIR4724 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR4724 Gene

Post-translational modifications for MIR4724 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR4724 Gene

No data available for DME Specific Peptides for MIR4724 Gene

Domains & Families for MIR4724 Gene

Gene Families for MIR4724 Gene

Protein Domains for MIR4724 Gene

Graphical View of Domain Structure for InterPro Entry

Q86YS3

UniProtKB/Swiss-Prot:

RFIP4_HUMAN :
  • The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B).
Domain:
  • The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B).
  • Contains 1 EF-hand domain.
  • Contains 1 FIP-RBD domain.
genes like me logo Genes that share domains with MIR4724: view

No data available for Suggested Antigen Peptide Sequences for MIR4724 Gene

Function for MIR4724 Gene

Molecular function for MIR4724 Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an address tag delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6.

Gene Ontology (GO) - Molecular Function for MIR4724 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI --
GO:0017137 Rab GTPase binding IPI --
GO:0030306 ADP-ribosylation factor binding IPI --
GO:0042803 protein homodimerization activity IDA --
genes like me logo Genes that share ontologies with MIR4724: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4724 Gene

Localization for MIR4724 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4724 Gene

Endosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Cytoplasmic vesicle. Note=Recruited to the cleavage furrow and the midbody during cytokinesis. {ECO:0000269 PubMed:15601896}.

Gene Ontology (GO) - Cellular Components for MIR4724 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with MIR4724: view

No data available for Subcellular locations from COMPARTMENTS for MIR4724 Gene

Pathways & Interactions for MIR4724 Gene

SuperPathways for MIR4724 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4724 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003407 neural retina development IEA --
GO:0006810 transport IEA --
GO:0016032 viral process IEA --
GO:1903452 positive regulation of G1 to G0 transition IEA --
genes like me logo Genes that share ontologies with MIR4724: view

No data available for Pathways by source and SIGNOR curated interactions for MIR4724 Gene

Transcripts for MIR4724 Gene

mRNA/cDNA for MIR4724 Gene

(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4724 Gene

No ASD Table

Relevant External Links for MIR4724 Gene

GeneLoc Exon Structure for
MIR4724
ECgene alternative splicing isoforms for
MIR4724

Expression for MIR4724 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4724 Gene

mRNA differential expression in normal tissues according to GTEx for MIR4724 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.2), Brain - Amygdala (x4.6), Brain - Hippocampus (x4.5), Brain - Substantia nigra (x4.3), and Brain - Putamen (basal ganglia) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of MIR4724 Gene:

MIR4724

mRNA Expression by UniProt/SwissProt for MIR4724 Gene:

Q86YS3-RFIP4_HUMAN
Tissue specificity: Present at high level in testis (at protein level). Weakly expressed in other tissues.
genes like me logo Genes that share expression patterns with MIR4724: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR4724 Gene

Orthologs for MIR4724 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR4724 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB11FIP4 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB11FIP4 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB11FIP4 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab11fip4 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB11FIP4 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB11FIP4 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB11FIP4 35
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB11FIP4 35
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rab11fip4a 35
  • 73 (a)
OneToMany
rab11fip4b 35
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta nuf 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F55C12.1 35
  • 21 (a)
OneToMany
Species where no ortholog for MIR4724 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR4724 Gene

ENSEMBL:
Gene Tree for MIR4724 (if available)
TreeFam:
Gene Tree for MIR4724 (if available)

Paralogs for MIR4724 Gene

Paralogs for MIR4724 Gene

genes like me logo Genes that share paralogs with MIR4724: view

Variants for MIR4724 Gene

Sequence variations from dbSNP and Humsavar for MIR4724 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1045865 -- 31,535,011(+) TTTTT(C/T)TTTTA downstream-variant-500B, utr-variant-3-prime
rs10574062 -- 31,534,000(+) TTTTA(-/AA)GATGG upstream-variant-2KB, utr-variant-3-prime
rs111392144 -- 31,533,885(+) GAGCA(A/G)GCCTG upstream-variant-2KB, utr-variant-3-prime
rs111690648 -- 31,533,517(+) AATAG(A/G)AAGGA upstream-variant-2KB, utr-variant-3-prime
rs112113299 -- 31,535,264(+) AAGTT(-/A)AAAAA downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR4724 Gene

Variant ID Type Subtype PubMed ID
nsv1064728 CNV gain 25217958

Relevant External Links for MIR4724 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4724

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4724 Gene

Disorders for MIR4724 Gene

Relevant External Links for MIR4724

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4724

No disorders were found for MIR4724 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4724 Gene

Publications for MIR4724 Gene

  1. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  4. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PMID: 20682791) Gorbea C. … Rechsteiner M. (J. Biol. Chem. 2010) 4 64
  5. HCMV-encoded glycoprotein M (UL100) interacts with Rab11 effector protein FIP4. (PMID: 19761540) Krzyzaniak M.A. … Britt W.J. (Traffic 2009) 4 64

Products for MIR4724 Gene

Sources for MIR4724 Gene

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