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Aliases for MIR4723 Gene

Subcategory (RNA class) for MIR4723 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4723 Gene

  • MicroRNA 4723 2 3
  • TMEM199 4 5
  • Transmembrane Protein 199 5
  • Hsa-Mir-4723 3
  • Mir-4723 3
  • C17orf32 4

External Ids for MIR4723 Gene

Previous GeneCards Identifiers for MIR4723 Gene

  • GC17U901642
  • GC17P026691
  • GC17P028360
  • GC17P028359

Summaries for MIR4723 Gene

Entrez Gene Summary for MIR4723 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4723 Gene

MIR4723 (MicroRNA 4723) is an RNA Gene, and is affiliated with the miRNA class.

UniProtKB/Swiss-Prot for MIR4723 Gene

  • May be involved in Golgi homeostasis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4723 Gene

Genomics for MIR4723 Gene

Regulatory Elements for MIR4723 Gene

Enhancers for MIR4723 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F027565 1.1 VISTA Ensembl ENCODE 24.5 -784.0 -784019 15.3 HDGF PKNOX1 ARNT WRNIP1 ZFP64 ARID4B DMAP1 ZNF143 ZNF207 FOS MIR4723 LGALS9 WSB1 PIR39350 PIR50901
GH17F029146 0.9 FANTOM5 ENCODE 21.2 +792.1 792123 6.7 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 MYO18A ENSG00000265289 NUFIP2 ENSG00000264647 MIR4723 TIAF1 NDUFS5P7 LOC105371715 LOC105371716 ENSG00000266111
GH17F028576 0.5 ENCODE 13.4 +219.6 219621 1.6 HDGF PKNOX1 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF143 SP3 SP5 ENSG00000264577 SDF2 MIR4723 NUFIP2 SPAG5-AS1 SGK494 RPL23A KIAA0100 PHF12 UNC119
GH17F028597 0.6 ENCODE 13.4 +241.4 241422 3.0 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS ZNF263 PROCA1 ENSG00000264577 SDF2 MIR4723 NUFIP2 RPL23A PHF12 SPAG5 SPAG5-AS1
GH17F028709 1.1 ENCODE 13.4 +353.9 353886 3.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 KLF13 ZNF263 PROCA1 ENSG00000264577 SDF2 MIR4723 NUFIP2 RPL23A PHF12 ENSG00000265205
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4723 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4723 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001343343 -81 1801 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 ZHX2 MXD4

Genomic Location for MIR4723 Gene

Chromosome:
17
Start:
28,357,581 bp from pter
End:
28,363,683 bp from pter
Size:
6,103 bases
Orientation:
Plus strand

Genomic View for MIR4723 Gene

Genes around MIR4723 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4723 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4723 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4723 Gene

Proteins for MIR4723 Gene

  • Protein details for MIR4723 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N511-TM199_HUMAN
    Recommended name:
    Transmembrane protein 199
    Protein Accession:
    Q8N511

    Protein attributes for MIR4723 Gene

    Size:
    208 amino acids
    Molecular mass:
    23130 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MIR4723 Gene

Post-translational modifications for MIR4723 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR4723 Gene

No data available for DME Specific Peptides for MIR4723 Gene

Domains & Families for MIR4723 Gene

Gene Families for MIR4723 Gene

Protein Domains for MIR4723 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4723: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4723 Gene

Function for MIR4723 Gene

Molecular function for MIR4723 Gene

UniProtKB/Swiss-Prot Function:
May be involved in Golgi homeostasis.

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4723 Gene

Localization for MIR4723 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4723 Gene

Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Note=Partial colocalization with GOLGB1. {ECO:0000269 PubMed:26833330}.

Gene Ontology (GO) - Cellular Components for MIR4723 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0030663 COPI-coated vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA --
genes like me logo Genes that share ontologies with MIR4723: view

No data available for Subcellular locations from COMPARTMENTS for MIR4723 Gene

Pathways & Interactions for MIR4723 Gene

SuperPathways for MIR4723 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4723 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4723 Gene

Transcripts for MIR4723 Gene

mRNA/cDNA for MIR4723 Gene

(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4723 Gene

No ASD Table

Relevant External Links for MIR4723 Gene

GeneLoc Exon Structure for
MIR4723
ECgene alternative splicing isoforms for
MIR4723

Expression for MIR4723 Gene

mRNA expression in normal human tissues for MIR4723 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4723 Gene:

MIR4723
genes like me logo Genes that share expression patterns with MIR4723: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4723 Gene

Orthologs for MIR4723 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR4723 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM199 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM199 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM199 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem199 35
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM199 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM199 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM199 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM199 35
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem199 35
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7071 35
  • 19 (a)
OneToOne
Species where no ortholog for MIR4723 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR4723 Gene

ENSEMBL:
Gene Tree for MIR4723 (if available)
TreeFam:
Gene Tree for MIR4723 (if available)

Paralogs for MIR4723 Gene

No data available for Paralogs for MIR4723 Gene

Variants for MIR4723 Gene

Sequence variations from dbSNP and Humsavar for MIR4723 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs869025587 Pathogenic 28,360,528(+) TCCCA(A/G)GATAC upstream-variant-2KB, splice-acceptor-variant
rs111913451 -- 28,359,742(+) TTTAC(A/G)AAAAA intron-variant, upstream-variant-2KB
rs111983481 -- 28,359,901(+) AGCAA(A/G)ACTCC intron-variant, upstream-variant-2KB
rs112153067 -- 28,359,316(+) TCAGA(A/G)CCCAG upstream-variant-2KB, reference, missense
rs112706021 -- 28,360,421(+) CATGG(A/G)GAGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4723 Gene

Variant ID Type Subtype PubMed ID
nsv1056839 CNV gain 25217958
nsv519388 CNV loss 19592680
nsv574653 CNV gain 21841781

Relevant External Links for MIR4723 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4723

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4723 Gene

Disorders for MIR4723 Gene

UniProtKB/Swiss-Prot

TM199_HUMAN
  • Congenital disorder of glycosylation 2P (CDG2P) [MIM:616829]: A form of congenital disorder of glycosylation, a genetically heterogeneous group of autosomal recessive, multisystem disorders caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. CDG2P is characterized by mild metabolic dysfunction, primarily affecting the liver. Psychomotor development is normal. {ECO:0000269 PubMed:26833330}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR4723

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4723

No disorders were found for MIR4723 Gene.

No data available for MalaCards and Genatlas for MIR4723 Gene

Publications for MIR4723 Gene

  1. TMEM199 Deficiency Is a Disorder of Golgi Homeostasis Characterized by Elevated Aminotransferases, Alkaline Phosphatase, and Cholesterol and Abnormal Glycosylation. (PMID: 26833330) Jansen J.C. … Lefeber D.J. (Am. J. Hum. Genet. 2016) 4 64
  2. Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels. (PMID: 25080503) Kwan J.S. … Kung A.W. (Hum. Mol. Genet. 2014) 3 64
  3. MicroRNA-4723 inhibits prostate cancer growth through inactivation of the Abelson family of nonreceptor protein tyrosine kinases. (PMID: 24223753) Arora S. … Dahiya R. (PLoS ONE 2013) 3 64
  4. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PMID: 22223895) Bienvenut W.V. … Giglione C. (Mol. Cell Proteomics 2012) 4 64
  5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64

Products for MIR4723 Gene

Sources for MIR4723 Gene

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