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Aliases for MIR4721 Gene

Subcategory (RNA class) for MIR4721 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4721 Gene

  • MicroRNA 4721 2 3
  • TUFM 4 5
  • Tu Translation Elongation Factor, Mitochondrial 5
  • Hsa-Mir-4721 3
  • EF-Tu 4
  • P43 4

External Ids for MIR4721 Gene

Previous GeneCards Identifiers for MIR4721 Gene

  • GC16U901344

Summaries for MIR4721 Gene

Entrez Gene Summary for MIR4721 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4721 Gene

MIR4721 (MicroRNA 4721) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4721 include Combined Oxidative Phosphorylation Deficiency 4. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. An important paralog of this gene is EEFSEC.

UniProtKB/Swiss-Prot for MIR4721 Gene

  • This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4721 Gene

Genomics for MIR4721 Gene

Regulatory Elements for MIR4721 Gene

Enhancers for MIR4721 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F028844 0.6 ENCODE 0.8 +0.2 206 3.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143 TUFM ENSG00000260853 SMG1P2 MIR4517 ENSG00000260367 NUPR1 RPS15AP33 RRN3P2 CDC37P1 MIR4721
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4721 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4721 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000051700 -192 2401 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143

Genomic Location for MIR4721 Gene

Chromosome:
16
Start:
28,842,411 bp from pter
End:
28,846,408 bp from pter
Size:
3,998 bases
Orientation:
Minus strand

Genomic View for MIR4721 Gene

Genes around MIR4721 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4721 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4721 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4721 Gene

Proteins for MIR4721 Gene

  • Protein details for MIR4721 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49411-EFTU_HUMAN
    Recommended name:
    Elongation factor Tu, mitochondrial
    Protein Accession:
    P49411
    Secondary Accessions:
    • O15276

    Protein attributes for MIR4721 Gene

    Size:
    452 amino acids
    Molecular mass:
    49542 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC60647.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH01633.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH10041.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MIR4721 Gene

Post-translational modifications for MIR4721 Gene

  • Ubiquitination at Lys 88 and Lys 311
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR4721 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MIR4721 Gene

Domains & Families for MIR4721 Gene

Gene Families for MIR4721 Gene

Graphical View of Domain Structure for InterPro Entry

P49411

UniProtKB/Swiss-Prot:

EFTU_HUMAN :
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
Domain:
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
genes like me logo Genes that share domains with MIR4721: view

No data available for Suggested Antigen Peptide Sequences for MIR4721 Gene

Function for MIR4721 Gene

Molecular function for MIR4721 Gene

UniProtKB/Swiss-Prot Function:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

Gene Ontology (GO) - Molecular Function for MIR4721 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003746 translation elongation factor activity IDA --
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI --
GO:0005525 GTP binding IEA --
GO:0044822 poly(A) RNA binding IDA --
genes like me logo Genes that share ontologies with MIR4721: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4721 Gene

Localization for MIR4721 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4721 Gene

Gene Ontology (GO) - Cellular Components for MIR4721 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IDA --
GO:0042645 mitochondrial nucleoid IDA --
genes like me logo Genes that share ontologies with MIR4721: view

No data available for Subcellular locations from COMPARTMENTS for MIR4721 Gene

Pathways & Interactions for MIR4721 Gene

genes like me logo Genes that share pathways with MIR4721: view

Pathways by source for MIR4721 Gene

Gene Ontology (GO) - Biological Process for MIR4721 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006414 translational elongation IDA --
GO:0045471 response to ethanol IEA --
GO:0070125 mitochondrial translational elongation IBA --
genes like me logo Genes that share ontologies with MIR4721: view

No data available for SIGNOR curated interactions for MIR4721 Gene

Transcripts for MIR4721 Gene

mRNA/cDNA for MIR4721 Gene

(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4721 Gene

No ASD Table

Relevant External Links for MIR4721 Gene

GeneLoc Exon Structure for
MIR4721
ECgene alternative splicing isoforms for
MIR4721

Expression for MIR4721 Gene

mRNA expression in normal human tissues for MIR4721 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4721 Gene:

MIR4721
genes like me logo Genes that share expression patterns with MIR4721: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4721 Gene

Orthologs for MIR4721 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR4721 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUFM 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TUFM 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TUFM 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tufm 35
  • 94 (a)
OneToMany
Gm9755 35
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TUFM 35
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TUFM 35
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TUFM 35
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tufm 35
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EfTuM 35
  • 55 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tufm-2 35
  • 42 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUF1 35 37
  • 56 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.888 35
  • 50 (a)
ManyToMany
Species where no ortholog for MIR4721 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR4721 Gene

ENSEMBL:
Gene Tree for MIR4721 (if available)
TreeFam:
Gene Tree for MIR4721 (if available)

Paralogs for MIR4721 Gene

Paralogs for MIR4721 Gene

Pseudogenes.org Pseudogenes for MIR4721 Gene

genes like me logo Genes that share paralogs with MIR4721: view

Variants for MIR4721 Gene

Sequence variations from dbSNP and Humsavar for MIR4721 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs121434452 Pathogenic 28,844,008(-) GCGGC(A/G)GGGCC upstream-variant-2KB, reference, missense
rs114590091 Likely benign 28,843,810(+) GGACA(C/T)AAAGG downstream-variant-500B, reference, missense
rs143189885 Uncertain significance 28,844,760(+) AAACT(C/T)GGTGA upstream-variant-2KB, reference, missense
rs779228479 Uncertain significance 28,844,301(+) TGCCA(C/T)GCTCT intron-variant, upstream-variant-2KB, reference, missense
rs11542257 Benign 28,845,961(-) ACCAT(C/G/T)GGCCA upstream-variant-2KB, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for MIR4721 Gene

Variant ID Type Subtype PubMed ID
dgv2830n100 CNV gain 25217958
dgv2831n100 CNV gain 25217958
dgv4987n54 CNV gain 21841781
dgv502e214 CNV loss 21293372
esv2758640 CNV gain+loss 17122850
esv3570454 CNV gain 25503493
esv3638348 CNV gain 21293372
esv3892826 CNV gain+loss 25118596
nsv1059555 CNV gain 25217958
nsv1064483 CNV loss 25217958
nsv518648 CNV loss 19592680
nsv519100 CNV gain 19592680
nsv571805 CNV loss 21841781

Relevant External Links for MIR4721 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4721

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4721 Gene

Disorders for MIR4721 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR4721 Gene - From: GeneCards

Disorder Aliases PubMed IDs
combined oxidative phosphorylation deficiency 4
  • coxpd4
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

EFTU_HUMAN
  • Combined oxidative phosphorylation deficiency 4 (COXPD4) [MIM:610678]: A mitochondrial disease resulting in neonatal lactic acidosis, rapidly progressive encephalopathy, severely decreased mitochondrial protein synthesis, and combined deficiency of mtDNA-related mitochondrial respiratory chain complexes. {ECO:0000269 PubMed:17160893}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR4721

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4721
genes like me logo Genes that share disorders with MIR4721: view

No data available for Genatlas for MIR4721 Gene

Publications for MIR4721 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  4. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64

Products for MIR4721 Gene

Sources for MIR4721 Gene

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