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Aliases for MIR4721 Gene

Subcategory (RNA class) for MIR4721 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4721 Gene

  • MicroRNA 4721 2 3 5
  • Hsa-Mir-4721 3

External Ids for MIR4721 Gene

Previous GeneCards Identifiers for MIR4721 Gene

  • GC16U901344

Summaries for MIR4721 Gene

Entrez Gene Summary for MIR4721 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4721 Gene

MIR4721 (MicroRNA 4721) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4721 include Combined Oxidative Phosphorylation Deficiency 4. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4721 Gene

Genomics for MIR4721 Gene

Regulatory Elements for MIR4721 Gene

Enhancers for MIR4721 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G028844 1.2 ENCODE 0.7 -2.2 -2196 3.0 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC TBX21 TUFM ENSG00000260853 SMG1P2 NFATC2IP ENSG00000260367 ENSG00000198106 ENSG00000261766 RPS15AP33 RRN3P2 ENSG00000251417
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4721 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4721 Gene

Chromosome:
16
Start:
28,843,919 bp from pter
End:
28,844,007 bp from pter
Size:
89 bases
Orientation:
Minus strand

Genomic View for MIR4721 Gene

Genes around MIR4721 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4721 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4721 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4721 Gene

ORGUL Member Location for MIR4721 Gene

ORGUL Member Location for MIR4721 gene

Proteins for MIR4721 Gene

Post-translational modifications for MIR4721 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4721 Gene

Domains & Families for MIR4721 Gene

Gene Families for MIR4721 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4721: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4721 Gene

Function for MIR4721 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4721 Gene

Localization for MIR4721 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4721 Gene

Pathways & Interactions for MIR4721 Gene

genes like me logo Genes that share pathways with MIR4721: view

Pathways by source for MIR4721 Gene

Interacting Proteins for MIR4721 Gene

Gene Ontology (GO) - Biological Process for MIR4721 Gene

None

No data available for SIGNOR curated interactions for MIR4721 Gene

Drugs & Compounds for MIR4721 Gene

No Compound Related Data Available

Transcripts for MIR4721 Gene

mRNA/cDNA for MIR4721 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4721 Gene

No ASD Table

Relevant External Links for MIR4721 Gene

GeneLoc Exon Structure for
MIR4721
ECgene alternative splicing isoforms for
MIR4721

Expression for MIR4721 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4721 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4721 Gene:

MIR4721
genes like me logo Genes that share expression patterns with MIR4721: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4721 Gene

Orthologs for MIR4721 Gene

Evolution for MIR4721 Gene

ENSEMBL:
Gene Tree for MIR4721 (if available)
TreeFam:
Gene Tree for MIR4721 (if available)

No data available for Orthologs for MIR4721 Gene

Paralogs for MIR4721 Gene

No data available for Paralogs for MIR4721 Gene

Variants for MIR4721 Gene

Sequence variations from dbSNP and Humsavar for MIR4721 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1057518742 Pathogenic 28,845,030(-) ACCCC(A/T)CGACG upstream-variant-2KB, reference, missense
rs1057518743 Pathogenic 28,845,997(-) ACTTA(-/C)GTGCG upstream-variant-2KB, reference, frameshift-variant
rs121434452 Pathogenic 28,844,008(-) GCGGC(A/G)GGGCC upstream-variant-2KB, reference, missense
rs11542257 Likely benign 28,845,961(-) ACCAT(C/G/T)GGCCA upstream-variant-2KB, reference, synonymous-codon
rs115691896 Uncertain significance 28,844,875(+) TGCCA(C/G)AGAGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4721 Gene

Variant ID Type Subtype PubMed ID
dgv2830n100 CNV gain 25217958
dgv2831n100 CNV gain 25217958
dgv4987n54 CNV gain 21841781
dgv502e214 CNV loss 21293372
esv2758640 CNV gain+loss 17122850
esv3570454 CNV gain 25503493
esv3638348 CNV gain 21293372
esv3892826 CNV gain+loss 25118596
nsv1059555 CNV gain 25217958
nsv1064483 CNV loss 25217958
nsv518648 CNV loss 19592680
nsv519100 CNV gain 19592680
nsv571805 CNV loss 21841781

Relevant External Links for MIR4721 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4721

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4721 Gene

Disorders for MIR4721 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR4721 Gene - From: GeneCards

Disorder Aliases PubMed IDs
combined oxidative phosphorylation deficiency 4
  • coxpd4
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR4721

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4721
genes like me logo Genes that share disorders with MIR4721: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR4721 Gene

Publications for MIR4721 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4721 Gene

Sources for MIR4721 Gene

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