Subcategory (RNA class) for MIR4720 Gene
Quality Score for this RNA gene is
Aliases for MIR4720 Gene
External Ids for MIR4720 Gene
Previous GeneCards Identifiers for MIR4720 Gene
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR4720 Gene
MIR4720 (MicroRNA 4720) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4720 include Giant Axonal Neuropathy and Giant Axonal Neuropathy-1. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is IPP.
UniProtKB/Swiss-Prot for MIR4720 Gene
Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.