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Aliases for MIR4709 Gene

Subcategory (RNA class) for MIR4709 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4709 Gene

  • MicroRNA 4709 2 3 5
  • Hsa-Mir-4709 3
  • Mir-4709 3

External Ids for MIR4709 Gene

Previous GeneCards Identifiers for MIR4709 Gene

  • GC14U901277
  • GC14M074949

Summaries for MIR4709 Gene

Entrez Gene Summary for MIR4709 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4709 Gene

MIR4709 (MicroRNA 4709) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Metabolism and Lipoprotein metabolism.

Additional gene information for MIR4709 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4709 Gene

Genomics for MIR4709 Gene

Regulatory Elements for MIR4709 Gene

Enhancers for MIR4709 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H074480 0.6 ENCODE 0.7 +1.0 992 0 CTCF ZNF654 SMC3 REST RAD21 RFX5 SYNDIG1L MIR4709 ENSG00000259005
GH14H074482 0.4 FANTOM5 0.7 -2.6 -2637 0 HLF ENSG00000270000 SYNDIG1L MIR4709 RAP1AP
GH14H074475 0.4 ENCODE 0.7 +4.4 4362 0 JUND MIR4709 ENSG00000259005
GH14H074479 0.4 ENCODE 0.7 +0.4 420 0 CTCF SYNDIG1L MIR4709 ENSG00000259005
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4709 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4709 Gene

Chromosome:
14
Start:
74,480,133 bp from pter
End:
74,480,204 bp from pter
Size:
72 bases
Orientation:
Minus strand

Genomic View for MIR4709 Gene

Genes around MIR4709 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4709 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4709 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4709 Gene

Proteins for MIR4709 Gene

Post-translational modifications for MIR4709 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4709 Gene

Domains & Families for MIR4709 Gene

Gene Families for MIR4709 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4709: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4709 Gene

Function for MIR4709 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR4709
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4709 Gene

Localization for MIR4709 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4709 Gene

Pathways & Interactions for MIR4709 Gene

genes like me logo Genes that share pathways with MIR4709: view

Interacting Proteins for MIR4709 Gene

Gene Ontology (GO) - Biological Process for MIR4709 Gene

None

No data available for SIGNOR curated interactions for MIR4709 Gene

Drugs & Compounds for MIR4709 Gene

No Compound Related Data Available

Transcripts for MIR4709 Gene

mRNA/cDNA for MIR4709 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR4709
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4709 Gene

No ASD Table

Relevant External Links for MIR4709 Gene

GeneLoc Exon Structure for
MIR4709
ECgene alternative splicing isoforms for
MIR4709

Expression for MIR4709 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4709 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4709 Gene:

MIR4709
genes like me logo Genes that share expression patterns with MIR4709: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4709 Gene

Orthologs for MIR4709 Gene

Evolution for MIR4709 Gene

ENSEMBL:
Gene Tree for MIR4709 (if available)
TreeFam:
Gene Tree for MIR4709 (if available)

No data available for Orthologs for MIR4709 Gene

Paralogs for MIR4709 Gene

No data available for Paralogs for MIR4709 Gene

Variants for MIR4709 Gene

Sequence variations from dbSNP and Humsavar for MIR4709 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs104894457 Pathogenic 74,480,707(-) CAGTA(C/T)AGATC upstream-variant-2KB, reference, stop-gained
rs140130028 Pathogenic 74,480,701(+) ACTTA(C/T)GATCT upstream-variant-2KB, reference, missense, splice-donor-variant
rs114950106 Likely benign 74,480,292(+) ACCTG(C/G/T)GGATG intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs75936194 Likely benign 74,480,003(+) AAGAG(A/G)CCACA downstream-variant-500B, utr-variant-3-prime
rs113587712 Uncertain significance 74,479,979(+) CAAGA(A/C/G)TAAAT downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR4709 Gene

Variant ID Type Subtype PubMed ID
esv3634943 CNV gain 21293372
nsv832829 CNV loss 17160897

Relevant External Links for MIR4709 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4709

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4709 Gene

Disorders for MIR4709 Gene

Relevant External Links for MIR4709

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4709

No disorders were found for MIR4709 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4709 Gene

Publications for MIR4709 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 60
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 60
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR4709 Gene

Sources for MIR4709 Gene

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